Zobrazeno 1 - 10
of 437
pro vyhledávání: '"Jose C. Florez"'
Autor:
Ravi Mandla, Philip Schroeder, Bianca Porneala, Jose C. Florez, James B. Meigs, Josep M. Mercader, Aaron Leong
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-13 (2024)
Abstract Background The clinical utility of genetic information for type 2 diabetes (T2D) prediction with polygenic scores (PGS) in ancestrally diverse, real-world US healthcare systems is unclear, especially for those at low clinical phenotypic risk
Externí odkaz:
https://doaj.org/article/39712f6c0dd2442c9dd63aedac4429c1
Autor:
Neftali Eduardo Antonio-Villa, Omar Yaxmehen Bello-Chavolla, Carlos A. Fermín-Martínez, Daniel Ramírez-García, Arsenio Vargas-Vázquez, Martín Roberto Basile-Alvarez, Alejandra Núñez-Luna, Paulina Sánchez-Castro, Luisa Fernández-Chirino, Juan Pablo Díaz-Sánchez, Gael Dávila-López, Rosalinda Posadas-Sánchez, Gilberto Vargas-Alarcón, A. Enrique Caballero, Jose C. Florez, Jacqueline A. Seiglie
Publikováno v:
The Lancet Regional Health. Americas, Vol 33, Iss , Pp 100732- (2024)
Summary: Background: Differences in the prevalence of four diabetes subgroups have been reported in Mexico compared to other populations, but factors that may contribute to these differences are poorly understood. Here, we estimate the prevalence of
Externí odkaz:
https://doaj.org/article/f5c1e6895a764c6aa18db860b90596e1
Autor:
Chloé Sarnowski, Tianxiao Huan, Yiyi Ma, Roby Joehanes, Alexa Beiser, Charles S. DeCarli, Nancy L. Heard-Costa, Daniel Levy, Honghuang Lin, Ching-Ti Liu, Chunyu Liu, James B. Meigs, Claudia L. Satizabal, Jose C. Florez, Marie-France Hivert, Josée Dupuis, Philip L. De Jager, David A. Bennett, Sudha Seshadri, Alanna C. Morrison
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-17 (2023)
Abstract Background Insulin resistance (IR) is a major risk factor for Alzheimer’s disease (AD) dementia. The mechanisms by which IR predisposes to AD are not well-understood. Epigenetic studies may help identify molecular signatures of IR associat
Externí odkaz:
https://doaj.org/article/d9f552a1cc0842fc826edbb499f07475
Autor:
Shivani Misra, Robert Wagner, Bige Ozkan, Martin Schön, Magdalena Sevilla-Gonzalez, Katsiaryna Prystupa, Caroline C. Wang, Raymond J. Kreienkamp, Sara J. Cromer, Mary R. Rooney, Daisy Duan, Anne Cathrine Baun Thuesen, Amelia S. Wallace, Aaron Leong, Aaron J. Deutsch, Mette K. Andersen, Liana K. Billings, Robert H. Eckel, Wayne Huey-Herng Sheu, Torben Hansen, Norbert Stefan, Mark O. Goodarzi, Debashree Ray, Elizabeth Selvin, Jose C. Florez, ADA/EASD PMDI, James B. Meigs, Miriam S. Udler
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-19 (2023)
Abstract Background Heterogeneity in type 2 diabetes presentation and progression suggests that precision medicine interventions could improve clinical outcomes. We undertook a systematic review to determine whether strategies to subclassify type 2 d
Externí odkaz:
https://doaj.org/article/46232ccfcc854e40a1a6c4c420987338
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/9ec034ee0d1140ea8437e717bc522d7a
Autor:
Philip H. Schroeder, Laura N. Brenner, Varinderpal Kaur, Sara J. Cromer, Katrina Armstrong, Regina C. LaRocque, Edward T. Ryan, James B. Meigs, Jose C. Florez, Richelle C. Charles, Josep M. Mercader, Aaron Leong
Publikováno v:
Cardiovascular Diabetology, Vol 21, Iss 1, Pp 1-13 (2022)
Abstract Background The high heterogeneity in the symptoms and severity of COVID-19 makes it challenging to identify high-risk patients early in the disease. Cardiometabolic comorbidities have shown strong associations with COVID-19 severity in epide
Externí odkaz:
https://doaj.org/article/ed44f593dbf5486ba14bfccf9e577310
Autor:
Daniel DiCorpo, Sheila M. Gaynor, Emily M. Russell, Kenneth E. Westerman, Laura M. Raffield, Timothy D. Majarian, Peitao Wu, Chloé Sarnowski, Heather M. Highland, Anne Jackson, Natalie R. Hasbani, Paul S. de Vries, Jennifer A. Brody, Bertha Hidalgo, Xiuqing Guo, James A. Perry, Jeffrey R. O’Connell, Samantha Lent, May E. Montasser, Brian E. Cade, Deepti Jain, Heming Wang, Ricardo D’Oliveira Albanus, Arushi Varshney, Lisa R. Yanek, Leslie Lange, Nicholette D. Palmer, Marcio Almeida, Juan M. Peralta, Stella Aslibekyan, Abigail S. Baldridge, Alain G. Bertoni, Lawrence F. Bielak, Chung-Shiuan Chen, Yii-Der Ida Chen, Won Jung Choi, Mark O. Goodarzi, James S. Floyd, Marguerite R. Irvin, Rita R. Kalyani, Tanika N. Kelly, Seonwook Lee, Ching-Ti Liu, Douglas Loesch, JoAnn E. Manson, Ryan L. Minster, Take Naseri, James S. Pankow, Laura J. Rasmussen-Torvik, Alexander P. Reiner, Muagututi’a Sefuiva Reupena, Elizabeth Selvin, Jennifer A. Smith, Daniel E. Weeks, Huichun Xu, Jie Yao, Wei Zhao, Stephen Parker, Alvaro Alonso, Donna K. Arnett, John Blangero, Eric Boerwinkle, Adolfo Correa, L. Adrienne Cupples, Joanne E. Curran, Ravindranath Duggirala, Jiang He, Susan R. Heckbert, Sharon L. R. Kardia, Ryan W. Kim, Charles Kooperberg, Simin Liu, Rasika A. Mathias, Stephen T. McGarvey, Braxton D. Mitchell, Alanna C. Morrison, Patricia A. Peyser, Bruce M. Psaty, Susan Redline, Alan R. Shuldiner, Kent D. Taylor, Ramachandran S. Vasan, Karine A. Viaud-Martinez, Jose C. Florez, James G. Wilson, Robert Sladek, Stephen S. Rich, Jerome I. Rotter, Xihong Lin, Josée Dupuis, James B. Meigs, Jennifer Wessel, Alisa K. Manning
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)
This study of 23,000 non-diabetic individuals highlights loci associated with fasting glucose and fasting insulin in diverse cohorts with whole genome sequence data.
Externí odkaz:
https://doaj.org/article/51bbec2d075c4bcf954b08126e8e0bab
Autor:
Kenneth E. Westerman, Timothy D. Majarian, Franco Giulianini, Dong-Keun Jang, Jenkai Miao, Jose C. Florez, Han Chen, Daniel I. Chasman, Miriam S. Udler, Alisa K. Manning, Joanne B. Cole
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Understanding how our genes interact with the environment is critical to improving health. Using a large-scale discovery pipeline, here the authors investigate synergies between genetic variants and a broad range of environmental factors impacting ca
Externí odkaz:
https://doaj.org/article/11be228dbd7845c8bdfbc58919ecc035
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
A variety of statistical approaches in nutritional epidemiology have been developed to enhance the precision of dietary variables derived from longitudinal questionnaires. Correlation with biomarkers is often used to assess the relative validity of t
Externí odkaz:
https://doaj.org/article/34a38b96c8534006aacafcb820a5aebc