Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Jose C. Alves-Filho"'
Autor:
Alexandre G. Maganin, Guilherme R. Souza, Miriam D. Fonseca, Alexandre H. Lopes, Rafaela M. Guimarães, André Dagostin, Nerry T. Cecilio, Atlante S. Mendes, William A. Gonçalves, Conceição E.A. Silva, Francisco Isaac Fernandes Gomes, Lucas M. Mauriz Marques, Rangel L. Silva, Letícia M. Arruda, Denis A. Santana, Henrique Lemos, Lei Huang, Marcela Davoli-Ferreira, Danielle Santana-Coelho, Morena B. Sant’Anna, Ricardo Kusuda, Jhimmy Talbot, Gabriela Pacholczyk, Gabriela A. Buqui, Norberto P. Lopes, Jose C. Alves-Filho, Ricardo M. Leão, Jason C. O’Connor, Fernando Q. Cunha, Andrew Mellor, Thiago M. Cunha
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 23 (2022)
Neuropathic pain is one of the most important clinical consequences of injury to the somatosensory system. Nevertheless, the critical pathophysiological mechanisms involved in neuropathic pain development are poorly understood. In this study, we foun
Externí odkaz:
https://doaj.org/article/c98ec044e03d4d9d88b85df1bc7f3f13
Autor:
Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin, Bernhard Ryffel, Thiago M. Cunha
Publikováno v:
Cell Communication and Signaling, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the molecular mechanisms of Cg-induced inflammation are not fully elucidated.
Externí odkaz:
https://doaj.org/article/fe56c29d443545788d694f1ed8880f87
Autor:
Sergio M. Borghi, Victor Fattori, Felipe A. Pinho-Ribeiro, Talita P. Domiciano, Milena M. Miranda-Sapla, Tiago H. Zaninelli, Rubia Casagrande, Phileno Pinge-Filho, Wander R. Pavanelli, Jose C. Alves-Filho, Fernando Q. Cunha, Thiago M. Cunha, Waldiceu A. Verri
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-23 (2019)
Abstract Background The cellular and molecular pathophysiological mecha\nisms of pain processing in neglected parasitic infections such as leishmaniasis remain unknown. The present study evaluated the participation of spinal cord glial cells in the p
Externí odkaz:
https://doaj.org/article/1444f579f42046eebfc3a07041fec0fc
Autor:
David F. Colón, Carlos W. Wanderley, Marcelo Franchin, Camila M. Silva, Carlos H. Hiroki, Fernanda V. S. Castanheira, Paula B. Donate, Alexandre H. Lopes, Leila C. Volpon, Silvia K. Kavaguti, Vanessa F. Borges, Cesar A. Speck-Hernandez, Fernando Ramalho, Ana P. Carlotti, Fabio Carmona, Jose C. Alves-Filho, Foo Y. Liew, Fernando Q. Cunha
Publikováno v:
Critical Care, Vol 23, Iss 1, Pp 1-13 (2019)
Abstract Background Neutrophil extracellular traps (NETs) are innate defense mechanisms that are also implicated in the pathogenesis of organ dysfunction. However, the role of NETs in pediatric sepsis is unknown. Methods Infant (2 weeks old) and adul
Externí odkaz:
https://doaj.org/article/33d631cf37c24ba2a665ac19751e0ba4
Autor:
Kenji W. Ruiz-Miyazawa, Sergio M. Borghi, Felipe A. Pinho-Ribeiro, Larissa Staurengo-Ferrari, Victor Fattori, Glaura S.A. Fernandes, Antonio M. Casella, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri, Jr
Publikováno v:
Journal of Functional Foods, Vol 48, Iss , Pp 106-116 (2018)
The effects and mechanisms of the citrus flavonoid naringenin were investigated in a mouse model of gout arthritis induced by intra-articular injection of monosodium urate crystals (MSU). Mice were treated with naringenin (16.7–150 mg/kg, per oral)
Externí odkaz:
https://doaj.org/article/208a79dccdf24b8bbd014a0f1ab7ca16
Autor:
Daniele C. Nascimento, Paulo H. Melo, Annie R. Piñeros, Raphael G. Ferreira, David F. Colón, Paula B. Donate, Fernanda V. Castanheira, Aline Gozzi, Paula G. Czaikoski, Wanda Niedbala, Marcos C. Borges, Dario S. Zamboni, Foo Y. Liew, Fernando Q. Cunha, Jose C. Alves-Filho
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-3
Externí odkaz:
https://doaj.org/article/14c052279c2943bbbeef427db07d64ab
Autor:
Yuri Lourenco-Gonzalez, Victor Fattori, Talita P. Domiciano, Ana C. Rossaneis, Sergio M. Borghi, Tiago H. Zaninelli, Catia C. F. Bernardy, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri
Publikováno v:
Mediators of Inflammation, Vol 2019 (2019)
Clinically active drugs for the treatment of acute pain have their prescription limited due to the significant side effects they induce. An increase in reactive oxygen species (ROS) has been linked to several conditions, including inflammation and pa
Externí odkaz:
https://doaj.org/article/ecec4d5a651847f292ee27dcac5acf29
Autor:
Victor Fattori, Ana C. Zarpelon, Larissa Staurengo-Ferrari, Sergio M. Borghi, Tiago H. Zaninelli, Fernando B. Da Costa, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Nilton S. Arakawa, Waldiceu A. Verri
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Gout is the most common inflammatory arthritis worldwide. It is a painful inflammatory disease induced by the deposition of monosodium urate (MSU) crystals in the joints and peri-articular tissues. Sesquiterpene lactones (SLs) are seconda
Externí odkaz:
https://doaj.org/article/8cb82856661a4646a8f61d11edee3e5b
Publikováno v:
Immunity. 56:232-234
Complement receptor C5aR1 signaling in sensory neuron-associated macrophages drives neuropathic pain
Autor:
Andreza U. Quadros, Alexandre G. M. Maganin, Conceição E. A. Silva, Samara Damasceno, Maria C. M. Cavallini, Marcela Davoli-Ferreira, Alexandre H. P. Lopes, Devi R. Sagar, Laura Brandolini, Sang Hoon Lee, Jose C. Alves-Filho, Fernando Q. Cunha, Temugin Berta, Jörg Köhl, Marcello Allegretti, Victoria Chapman, Thiago M. Cunha
Neuroimmune interactions across the pain pathway play a predominant role in the development of neuropathic pain. Previous reports demonstrated that complement driven effector systems including the C5a/C5aR1 axis contribute to these neuro-immune mecha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eeeef4ea50229f11b1ef678e933d5376
https://doi.org/10.1101/2022.07.01.498487
https://doi.org/10.1101/2022.07.01.498487