Zobrazeno 1 - 10 of 27 pro vyhledávání: '"Jose C Cruz"'
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Efficacy and safety of venetoclax in combination with azacitidine or decitabine in an outpatient setting in patients with untreated acute myeloid leukemia
Autor: Sudhir Manda, Bertrand Marquess Anz, Christopher Benton, E. Randolph Broun, Habte Aragaw Yimer, Jason M. Melear, Jose C. Cruz, Suzanne Fanning, Jeff Porter Sharman, Kingston Kang, Anders Svensson, Madhavi Pai, George F. Geils, John Scott Renshaw, William Bruce Donnellan
Publikováno v: Journal of Clinical Oncology. 40:7044-7044
7044 Background: Venetoclax (Ven), a highly selective BCL-2 inhibitor, combined with hypomethylating agents (HMAs) azacitidine (Aza) or decitabine (Dec) is approved for the treatment of newly diagnosed acute myeloid leukemia (ND AML) in patients (pts
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0890d0b87ba42de3ea04269e54f236b1
https://doi.org/10.1200/jco.2022.40.16_suppl.7044
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4
Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, combined with azacitidine in patients with AML
Autor: Jesus G. Berdeja, Ronan T. Swords, Farhad Sedarati, Michael R. Savona, Iwona Pawlikowska-Dobler, Bruce J. Dezube, Ajeeta B Dash, Joshua F. Zeidner, Douglas V. Faller, Steven Coutre, Jose C. Cruz, James M. Foran, Hélène M. Faessel, Saran Vardhanabhuti, Wayne Tam, Harry P. Erba, Michael B. Maris
Publikováno v: Blood. 131:1415-1424
Pevonedistat (TAK-924/MLN4924) is a novel inhibitor of NEDD8-activating enzyme (NAE) with single-agent activity in relapsed/refractory acute myeloid leukemia (AML). We performed a phase 1b study of pevonedistat (PEV) with azacitidine (AZA) based on s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d3f6a4681bd359374caf26c9ed327f5
https://doi.org/10.1182/blood-2017-09-805895
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5
First in Human Study of an on/Off Switchable CAR-T Cell Platform Targeting CD19 for B Cell Malignancies (CLBR001 + SWI019)
Autor: Jing Li, Rakhee Vaidya, Travis S. Young, Carolyn Mulroney, Ian W. Flinn, Jonathan Strauss, Vadim Klyushnichenko, Koen van Besien, Peter A. Riedell, Eduardo Laborda, Jose C. Cruz, Liana Nikolaenko, Mohit Trikha, Peter G. Schultz, Michael Emde
Publikováno v: Blood. 138:2822-2822
BACKGROUND: CD19 targeted chimeric antigen receptor (CAR) T cells are a transformative treatment option for patients with relapsed, refractory B cell malignancies. Despite remarkable responses in heavily pretreated patients, challenges remain related
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::954fe3fb62edb5dc0cd58666d5dabaee
https://doi.org/10.1182/blood-2021-151727
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6
Treatment Initiation of Venetoclax in Combination with Azacitidine or Decitabine in an Outpatient Setting in Patients with Untreated Acute Myeloid Leukemia
Autor: Christopher B. Benton, Sudhir Manda, Jose C. Cruz, George F. Geils, Suzanne R. Fanning, William B. Donnellan, Jason M. Melear, Jeff P. Sharman, Bertrand Anz, Anders Svensson, Habte A. Yimer, John Renshaw, E. Randolph Broun, Madhavi Pai, Kingston Kang
Publikováno v: Blood. 138:1265-1265
Background: Venetoclax (Ven), a highly selective BCL-2 inhibitor, combined with azacitidine (Aza) suppresses oxidative phosphorylation, which selectively targets leukemia stem cells that drive initiation and perpetuation of acute myeloid leukemia (AM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b1f0a78da92d6d70a52fe698ff480a6a
https://doi.org/10.1182/blood-2021-144886
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7
A Phase 1 Study of Gilteritinib in Combination with Induction and Consolidation Chemotherapy in Patients with Newly Diagnosed AML: Final Results
Autor: Tara L. Lin, Gary J. Schiller, Ramon V. Tiu, Jason Hill, Nikolai A. Podoltsev, Angela James, Brenda W. Cooper, Joseph G. Jurcic, Mohamad Cherry, Mark J. Levis, Qiaoyang Lu, Jose C. Cruz, Keith W. Pratz, Jessica K. Altman, Alexander E. Perl
Publikováno v: Blood. 136:16-17
Background: Gilteritinib, an oral FMS-like tyrosine kinase 3 (FLT3) inhibitor, demonstrated antileukemic responses in patients with FLT3-mutated (FLT3mut+) relapsed/refractory acute myeloid leukemia (AML). We report final results from a phase 1 study
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::db117bff8ed09ea722a3605d43ce71b6
https://doi.org/10.1182/blood-2020-137685
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8
Optimization of Antimicrobial Prophylaxis in Patients Undergoing Hematopoietic Stem Cell Transplantation Utilizing an Absolute Neutrophil Count Driven Approach
Autor: Jackie Kemp, Gerard W. Gawrys, Jose C. Cruz, Paul J. Shaughnessy, Brittney Ramirez, Justin G. Horowitz, Grace C. Lee
Publikováno v: Biology of Blood and Marrow Transplantation. 26:S317
Background Hematopoietic stem cell transplantation (HSCT) recipients often develop profound neutropenia and are ultimately at an increased risk of developing life-threatening infections peri-engraftment. There is discordance in the current guidelines
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dd8ce4425bf5507fa8c7fd9bce721b10
https://doi.org/10.1016/j.bbmt.2019.12.338
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9
Utility of T2Bacteria Panel for Antibiotic Stewardship in Patients Undergoing Hematopoietic Stem Cell Transplantation
Autor: Jackie Kemp, Carole Elledge, C. B. Jackson, Cesar O. Freytes, Justin G. Horowitz, Paul J. Shaughnessy, Jose C. Cruz, Gerard W. Gawrys, Brenda Astorga
Publikováno v: Biology of Blood and Marrow Transplantation. 26:S329
Background More than approximately 80% of hematopoietic stem cell transplant (HSCT) patients develop neutropenic fever warranting anti-Pseudomonal therapy (APT). Although Pseudomonas is not the most common pathogen causing febrile neutropenia, APT is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8eeccaab27a1f93b32f6a1161b8f8fe4
https://doi.org/10.1016/j.bbmt.2019.12.354
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