Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Jose Angel Gonzalo"'
Autor:
Diana I. Albu, Benjamin J. Wolf, Yan Qin, Xianzhe Wang, Amy Daniel Ulumben, Mei Su, Vivian Li, Eirene Ding, Jose Angel Gonzalo, Jason Kong, Ruturaj Jadhav, Nelly Kuklin, Alberto Visintin, Bing Gong, Thomas J. Schuetz
Publikováno v:
OncoImmunology, Vol 13, Iss 1 (2024)
ABSTRACTCombinatorial strategies, such as targeting different immune checkpoint receptors, hold promise to increase the breadth and duration of the response to cancer therapy. Here we describe the preclinical evaluation of CTX-8371, a protein constru
Externí odkaz:
https://doaj.org/article/5e1ca35cffdd474daf5caef1c125a47e
Autor:
Kenneth C. Malcolm, Jose-Angel Gonzalo, Joseph M. Petty, G. Scott Worthen, Jerry A. Nick, Peter M. Henson, Scott K. Young, Benjamin T. Suratt, Jonathan G. Lieber
Publikováno v:
Blood. 104:565-571
The bone marrow is the primary site for neutrophil production and release into the circulation. Because the CXC chemokine receptor-4/stromal derived factor-1 (CXCR4/SDF-1) axis plays a central role in the interactions of hematopoietic stem cells, lym
Autor:
Anthony J. Coyle, Justin Corcoran, Tracy Delaney, James B. Rottman, Amal Al-Garawi, Jose M. Lora, Jane Tian, Richard A. Kroczek, Jose-Carlos Gutierrez-Ramos, Jose Angel Gonzalo
Publikováno v:
Nature Immunology. 2:597-604
We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolyt
Autor:
M. L. Kapsenberg, Clare M. Lloyd, Anthony J. Coyle, Jose-Carlos Gutierrez-Ramos, Jose-Angel Gonzalo
Publikováno v:
Immunological Reviews. 177:31-42
The understanding of the relative contribution of particular chemokines to the selective accumulation of leukocyte subsets to an organ site during an inflammatory response is made difficult by the simultaneous presence of multiple chemokines with par
Autor:
Jose-Angel Gonzalo, Yang Pan, Clare M. Lloyd, Gui-Quan Jia, Gary Yu, Barry Dussault, Christine A. Powers, Amanda E. I. Proudfoot, Anthony J. Coyle, David Gearing, Jose-Carlos Gutierrez-Ramos
Publikováno v:
The Journal of Immunology. 163:403-411
The cloning, expression, and function of the murine (m) homologue of human (h) monocyte-derived chemokine (MDC) is reported here. Like hMDC, mMDC is able to elicit the chemotactic migration in vitro of activated lymphocytes and monocytes. Among activ
Autor:
J. C. Gutierrez-Ramos, Andrés Hidalgo, Denisa D. Wagner, Gui-Quan Jia, Myron I. Cybulsky, Jose-Angel Gonzalo
Publikováno v:
Europe PubMed Central
We have recently cloned eotaxin, a highly efficacious eosinophilic chemokine involved in the development of lung eosinophilia during allergic inflammatory reactions. To understand more precisely how eotaxin facilitates the specific migration of eosin
Publikováno v:
Blood. 91:1909-1916
During inflammatory processes, inflamed tissues signal the bone marrow (BM) to produce more mature leukocytes in ways that are not yet understood. We report here that, during the development of lung allergic inflammation, the administration of neutra
Autor:
Clare M. Lloyd, Anthony J. Coyle, Torbjörn Bjerke, Timothy N. C. Wells, Juan Pablo Albar, Danyi Wen, Martin E. Dorf, Amanda E. I. Proudfoot, Jose-Angel Gonzalo, Carlos Martínez-A, Jose-Carlos Gutierrez-Ramos
Publikováno v:
The Journal of Experimental Medicine
The complex pathophysiology of lung allergic inflammation and bronchial hyperresponsiveness (BHR) that characterize asthma is achieved by the regulated accumulation and activation of different leukocyte subsets in the lung. The development and mainte
Autor:
Barry J. Dussault, Hong Zhou, Janice A. Culpepper, Jim Deeds, David P. Gearing, Jose-Carlos Gutierrez-Ramos, Mike L. Gosselin, Jim Vath, Clare M. Lloyd, Sylvia Dolich, Jose-Angel Gonzalo, Elizabeth A. Woolf, Yang Pan, Geoff Alperin, Jingya Ma
Publikováno v:
Nature. 387:611-617
Chemokines are small secreted proteins that stimulate the directional migration of leukocytes and mediate inflammation. During screening of a murine choroid plexus complementary DNA library, we identified a new chemokine, designated neurotactin. Unli
Autor:
Jose C. Gutierrez-Ramos, Gui-Quan Jia, V. Aguirre, A. J. Coyle, Jose-Angel Gonzalo, N. A. Jenkins, N. Copeland, Howard R. Katz, Daniel S. Friend, Andrew H. Lichtman, Manfred Kopf, G. S. Lin
Publikováno v:
Immunity. 4(1):1-14
A model of lung eosinophilia based on the repeated exposure of mice to aerosolized OVA has been used to identify C–C chemokine genes expressed at stages of massive eosinophil infiltration. We describe the identification and cloning of a cDNA that e