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Long term survival in diffuse infiltrative brainstem gliomas in children and adolescents treated with radiotherapy and Nimotuzumab

Autor: Jesús Reno, Migdalia Perez, Ramon Ropero, Ivon Chon, Mariuska Forteza, José Luis García Valdés, Débora García, Jose Alert

Publikováno v: International Journal of Radiology & Radiation Therapy. 5

Objectives This study is devoted to the evaluation of the possibility and effectiveness of re irradiation treatment of children and adolescents with the relapses of diffusely growing brainstem tumor BST Methods Repeated radiotherapy was performed in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63360f887e72455d6e4e2186036baa7d
https://doi.org/10.15406/ijrrt.2018.05.00175

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Prolonged Use of Nimotuzumab in Children with Central Nervous System Tumors: Safety and Feasibility

Autor: Lorenzo Luaces P, J. Valdés, M.C. González, Infante M, Saurez G, Crombet Ramos T, M. Ríos, R. Herrera, Fernández A, Jose Alert, R. Cabanas, Valle L, Hechavarria E, M. Avila, J.L. Pedrayes, Reyes A

Publikováno v: Cancer Biotherapy and Radiopharmaceuticals. 29:173-178

Primary brain tumors constitute the most frequent solid tumor of childhood. High expression of the epidermal growth factor receptor (EGFR) protein has been associated with tumor progression and enhanced tumorigenicity in adult and children gliomas. N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a872901f0e508b7bfa611a737779d821
https://doi.org/10.1089/cbr.2013.1591

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Nimotuzumab in combination with radiotherapy in high grade glioma patients

Autor: Jose Alert, Maria Teresa Solomon, Nederlay Miranda, Eugenia Jorrín, Ivonne Chon, Jorge Juan Marinello, Patricia Lorenzo-Luaces, Tania Crombet

Publikováno v: Cancer Biology & Therapy. 15:504-509

Nimotuzumab, a humanized antibody targeting epidermal growth factor receptor, has potent anti-proliferative, anti-angiogenic, and pro-apoptotic effects in vitro and in vivo. It also reduces the number of radio-resistant CD133(+) glioma stem cells. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::303858d714778ee13e9ff7aebdb4260a
https://doi.org/10.4161/cbt.28021

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Treatment of children with high grade glioma with nimotuzumab: A 5-y institutional experience

Autor: Jorge Luis Pedrayes, Giselle Saurez, Ricardo Cabanas, Adnolys Reyes, Myrna Moreno, Jose Valdes, Mariela Infante, María Caridad González, Jose Alert, Patricia Lorenzo Luaces, Ernesto Echevarria, Raiza Herrera, Tania Crombet Ramos, Martha Rios, Melba Avila

Publikováno v: mAbs. 5:202-207

Brain tumors are a major cause of cancer-related mortality in children. Overexpression of epidermal growth factor receptor (EGFR) is detected in pediatric brain tumors and receptor density appears to increase with tumor grading. Nimotuzumab is an IgG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b3115a627d40dd75c0b3bddc5e77526
https://doi.org/10.4161/mabs.22970

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Multinational assessment of some operational costs of teletherapy

Autor: Debbie van der Merwe, Dimitris Kardamakis, Piet Hein Van Der Giessen, Luis V Pinillos, Deepak D. Deshpande, Rena Sajjad, Neiro Da Motta, Matija Bistrovic, Cholid Badri, Jose Alert, Ye Tian, Vic Levin

Publikováno v: Radiotherapy and Oncology. 71:347-355

Background and purpose: Decisions in planning radiotherapy facilities in countries with limited financial resources require information on economic factors to make provision for sustainability. This study aims at acquiring data on some of these facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35429ef95fa9218658a7fbbdde8a508e
https://doi.org/10.1016/j.radonc.2004.02.021

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Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck

Publikováno v: Cancer biologytherapy. 9(5)

The prognosis of patients with advanced head and neck cancer remain dismal. For this tumor type, elevated levels of EGFR are associated with a shorter disease free survival and time to treatment failure, reflecting a more aggressive phenotype. Nimotu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7002d0dd25af525a49a9c1c06b5997ef
https://pubmed.ncbi.nlm.nih.gov/20448462

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Radiotherapy plus the anti-EGFR mAb nimotuzumab or placebo for the treatment of high-grade glioma patients

Autor: F. Bach, Rafael Dominguez, Maria Teresa Solomon, Javier Figueredo, Normando Iznaga, Nelson Quintanal, Julio Cesar Selva, Mauricio Catala, Jose Vaquer, Jorge Juan Marinello, Jose Alert, Carolina Toledo, Tania Crombet Ramos, Patrcia Lorenzo Luaces, Silvia Salva, Martha Gonzalez Griego

Publikováno v: Journal of Clinical Oncology. 30:2515-2515

2515 Background: Despite remarkable advances in multimodal therapy, high grade glioma (HGG) patients still face a poor prognosis. EGFR is well validated as a primary contributor of HGG initiation and progression. Nimotuzumab is a humanized monoclonal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2f330b4fd058dac11d1220bd9ba680ca
https://doi.org/10.1200/jco.2012.30.15_suppl.2515

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