Výsledky vyhledávání - "Jose A. Morin"

Sequence-dependent surface condensation of a pioneer transcription factor on DNA

Autor: Jose A. Morin, Sina Wittmann, Sandeep Choubey, Adam Klosin, Stefan Golfier, Anthony A. Hyman, Frank Jülicher, Stephan W. Grill

Publikováno v: Nature Physics. 18:271-276

Biomolecular condensates are dense assemblies of proteins that form distinct biochemical compartments without being surrounded by a membrane. Some, such as P granules and stress granules, behave as droplets and contain many millions of molecules. Oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::494916000130a6bb0bba3e5873a5de8b
https://doi.org/10.1038/s41567-021-01462-2

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Data and task orchestration defined by spatio-temporal variables for healthcare data science services

Autor: Jose Carlos Morin Garcia, Juan Armando Barron Lugo, Jose Luis Gonzalez Compean, Ivan Lopez Arevalo, Jesus Carretero, Martha Cordero Oropeza

Publikováno v: Proceedings of the 9th International Conference on Bioinformatics Research and Applications.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1c471abdb23bef01121d6afea0b6196
https://doi.org/10.1145/3569192.3569208

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Co-condensation of proteins with single- and double-stranded DNA

Autor: Martine Ruer-Gruss, Frank Jülicher, Roman Renger, Jose A. Morin, Stephan W. Grill, Regis P. Lemaitre, Andreas Hermann

Summary Biomolecular condensates provide distinct compartments that can localize and organize biochemistry inside cells. Recent evidence suggests that condensate formation is prevalent in the cell nucleus and associated with a variety of important pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3334904ac7d5f2b74a1a87c4cc003b01
https://doi.org/10.1101/2021.03.17.435834

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Methods in Molecular Biology

Autor: Fernando Cerrón, Borja Ibarra, Jose A. Morin, Francisco J. Cao-García

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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Methods in Molecular Biology ISBN: 9781071612897

Optical tweezers enable the isolation and mechanical manipulation of individual nucleoprotein complexes. Here, we describe how to use this technique to interrogate the mechanical properties of individual protein-DNA complexes and extract information

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f824d7b2bbb77d050c53d86559b24b6
http://hdl.handle.net/20.500.12614/2603

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Surface condensation of a pioneer transcription factor on DNA

Autor: Anthony A. Hyman, Adam Klosin, Frank Jülicher, Sina Wittmann, Stefan Golfier, Sandeep Choubey, Jose A. Morin, Stephan W. Grill

In the last decade, extensive studies on the properties of non-membrane-bound compartments in the cellular cytoplasm have shown that concepts in phase separation drawn from physical chemistry can describe their formation and behaviour1–4. Current e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1477d1c1ad9c7bc487446f7daffa5e25
https://doi.org/10.1101/2020.09.24.311712

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Mechanics, thermodynamics, and kinetics of ligand binding to biopolymers

Autor: Jose A. Morin, Elena Beltrán-Heredia, Borja Ibarra, Francisco J. Cao, Juan P. G. Villaluenga, Javier Jarillo

Publikováno v: PLoS ONE
PLoS ONE, Vol 12, Iss 4, p e0174830 (2017)
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
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E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM

Ligands binding to polymers regulate polymer functions by changing their physical and chemical properties. This ligand regulation plays a key role in many biological processes. We propose here a model to explain the mechanical, thermodynamic, and kin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a172e5d5d2df0dc797cacfd0e0d0dae8
https://pubmed.ncbi.nlm.nih.gov/28380044

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Kinetic modeling of molecular motors: pause model and parameter determination from single-molecule experiments

Autor: Jose A. Morin, Francisco J. Cao, Borja Ibarra

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
E-Prints Complutense. Archivo Institucional de la UCM

Single-molecule manipulation experiments of molecular motors provide essential information about the rate and conformational changes of the steps of the reaction located along the manipulation coordinate. This information is not always sufficient to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47be2ba390a7c5666cfc69661696a46d
https://eprints.ucm.es/38635/

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Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase

Autor: J. Ricardo Arias-Gonzalez, Francisco J. Cao, José M. Lázaro, Jose A. Morin, Borja Ibarra, Margarita Salas, José L. Carrascosa, José M. Valpuesta

Publikováno v: E-Prints Complutense: Archivo Institucional de la UCM
Universidad Complutense de Madrid
RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname
Nucleic Acids Research
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
E-Prints Complutense. Archivo Institucional de la UCM

[EN] During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers to study the translocation mec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2aeb3add5985bf900473a2ea650cff67
https://hdl.handle.net/10251/152802

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Active DNA unwinding dynamics during processive DNA replication

Autor: Margarita Salas, José M. Valpuesta, Francisco J. Cao, José L. Carrascosa, Borja Ibarra, J. Ricardo Arias-Gonzalez, José M. Lázaro, Jose A. Morin

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Duplication of double-stranded DNA (dsDNA) requires a fine-tuned coordination between the DNA replication and unwinding reactions. Using optical tweezers, we probed the coupling dynamics between these two activities when they are simultaneously carri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::525642037a546da04de0c8e0f7dda108
https://europepmc.org/articles/PMC3361432/

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Manipulation of single polymerase-DNA complexes: A mechanical view of DNA unwinding during replication

Autor: José M. Carrascosa, Margarita Salas, Francisco J. Cao, José M. Valpuesta, Borja Ibarra, Jose A. Morin

Publikováno v: Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia
instname
Digital.CSIC. Repositorio Institucional del CSIC
Cell Cycle

DNA replication requires overcoming the energetic barrier associated with the base pair melting of its double helix and a fine-tuned coordination between the processes of DNA unwinding and DNA replication. One intriguing question that remains poorly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d8d5a3fde40621ce770bebcfb10b4b
http://hdl.handle.net/20.500.12614/615

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