The role of protease-activated receptor 1 signaling in CD8 T cell effector functions

Autor: Pablo M. Irusta, Rebecca B. Hasley, Mindy Smith, Hui Chen, Dorian B. McGavern, Cecile Le Saout, Jie Cheng, Jose A. Martina, Tatiana S. Karpova, Ziang Zhu, Marta Catalfamo, Jasmin Herz, Andres Gronda, Tong Li

Publikováno v: iScience
iScience, Vol 24, Iss 11, Pp 103387-(2021)

Summary CD8 T cells are essential for adaptive immunity against viral infections. Protease activated receptor 1 (PAR1) is expressed by CD8 T cells; however, its role in T cell effector function is not well defined. Here we show that in human CD8 T ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06bbefd1ebb156e887124802c385352b
http://europepmc.org/articles/PMC8605340

A conserved cysteine‐based redox mechanism sustains TFEB/HLH‐30 activity under persistent stress

Autor: Jose A. Martina, José Antonio Bárcena, Antonio Miranda-Vizuete, Rosa Puertollano, David Guerrero-Gómez, Eva Gómez-Orte, Juan Cabello

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
EMBO J

Mammalian TFEB and TFE3, as well as their ortholog in Caenorhabditis elegans HLH‐30, play an important role in mediating cellular response to a variety of stress conditions, including nutrient deprivation, oxidative stress, and pathogen infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b768a8cc540e9eff3c0c3a5653f28d83
https://doi.org/10.15252/embj.2020105793

Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress

Autor: Rosa Puertollano, Jose A. Martina

Publikováno v: Journal of Biological Chemistry. 293:12525-12534

Adaptations and responses to stress conditions are fundamental processes that all cells must accomplish to maintain or restore cellular homeostasis. Cells have a plethora of response pathways to mitigate the effect of different environmental stressor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bbc219a771ca925aff640a32bc100b
https://doi.org/10.1074/jbc.ra118.003471

Improved efficacy of a next-generation ERT in murine Pompe disease

Autor: Yi Lun, Anju Nair, Anadina Garcia, Jessie Feng, Kenneth J. Valenzano, Tuske Steven, Rosa Puertollano, Richie Khanna, Michelle Frascella, Su Xu, Russell Gotschall, Jose A. Martina, Maria Cecilia Della Valle, Evelyn Ralston, Adriane Schilling, Hung V. Do, Nina Raben, Abdul S. Ponery, Rebecca Soska

Publikováno v: JCI Insight. 4

Pompe disease is a rare inherited disorder of lysosomal glycogen metabolism due to acid α-glucosidase (GAA) deficiency. Enzyme replacement therapy (ERT) using alglucosidase alfa, a recombinant human GAA (rhGAA), is the only approved treatment for Po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f12ff3199f2c555ef7abb754419f457
https://doi.org/10.1172/jci.insight.125358

The transcription factors TFEB and TFE3 link the FLCN-AMPK signaling axis to innate immune response and pathogen resistance

Autor: Elite Possik, Eric H. Ma, Mathieu Paquette, Russell G. Jones, Jose A. Martina, Arnim Pause, Paola Blanchette, Tarika Vijayaraghavan, Rosa Puertollano, Leeanna El-Houjeiri, Jalal M. Kazan

Publikováno v: Cell Rep
Cell Reports, Vol 26, Iss 13, Pp 3613-3628.e6 (2019)

Summary: TFEB and TFE3 are transcriptional regulators of the innate immune response, but the mechanisms regulating their activation upon pathogen infection are poorly elucidated. Using C. elegans and mammalian models, we report that the master metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c8adceda6490af340ba5877ce729f0
https://doi.org/10.1101/463430