Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Jose, Brea"'
Autor:
Jaime R. Torres, Jose Brea-Del Castillo, Xavier Saez-Llorens, María L. Ávila-Agüero, Wilfrido Coronell R, Celia Martinez-De Cuellar, Roberto Debbag
Publikováno v:
Expert Review of Vaccines, Vol 23, Iss 1, Pp 773-778 (2024)
Introduction Dengue disease represents a large and growing global threat to public health, accounting for a significant burden to health systems of endemic countries. The World Health Organization’s (WHO) Strategic Advisory Group of Experts (SAGE)
Externí odkaz:
https://doaj.org/article/b3d37880300b49689f1917a7151f10d1
Autor:
Elk Kossatz, Rebeca Diez-Alarcia, Supriya A. Gaitonde, Carla Ramon-Duaso, Tomasz Maciej Stepniewski, David Aranda-Garcia, Itziar Muneta-Arrate, Elodie Tepaz, Suwipa Saen-Oon, Robert Soliva, Aida Shahraki, David Moreira, Jose Brea, Maria Isabel Loza, Rafael de la Torre, Peter Kolb, Michel Bouvier, J. Javier Meana, Patricia Robledo, Jana Selent
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract G protein-coupled receptors (GPCRs) are sophisticated signaling machines able to simultaneously elicit multiple intracellular signaling pathways upon activation. Complete (in)activation of all pathways can be counterproductive for specific t
Externí odkaz:
https://doaj.org/article/455c7d7ebe814812996e6683dd1c4a42
Publikováno v:
SLAS Discovery, Vol 29, Iss 3, Pp 100149- (2024)
The purpose of the protocol reported in this work is the solubility profiling of large chemical libraries using nephelometry. This technique allows the qualitative classification of compounds as highly, moderately, or poorly water-soluble. The descri
Externí odkaz:
https://doaj.org/article/2eb26bff2dc948e3abacc5552d6a6141
Autor:
Clément Anfray, Carmen Fernández Varela, Aldo Ummarino, Akihiro Maeda, Marina Sironi, Sara Gandoy, Jose Brea, María Isabel Loza, Sergio León, Alfonso Calvo, Juan Correa, Eduardo Fernandez-Megia, María José Alonso, Paola Allavena, José Crecente-Campo, Fernando Torres Andón
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
BackgroundIn the tumor microenvironment (TME), tumor-associated macrophages (TAMs) play a key immunosuppressive role that limits the ability of the immune system to fight cancer. Toll-like receptors (TLRs) ligands, such as poly(I:C) or resiquimod (R8
Externí odkaz:
https://doaj.org/article/6cca62f205fd47608a66754ddd717c91
Autor:
Filipe Areias, Carla Correia, Ashly Rocha, Sofia Teixeira, Marián Castro, Jose Brea, Huabin Hu, Jens Carlsson, Maria I. Loza, M. Fernanda Proença, M. Alice Carvalho
Publikováno v:
Molecules, Vol 29, Iss 11, p 2543 (2024)
A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed through radioligand binding tests at human A1, A2A, A2B, and A3 adenosine receptor subtypes. Eleven purines showed potent antagonism at A1, A3, dual A1/A2A, A1/
Externí odkaz:
https://doaj.org/article/7cbea8944ba641e096dee5b96a2e909e
Autor:
Roberto Debbag, Jaime R. Torres, Luiza H. Falleiros-Arlant, Maria L. Avila-Aguero, Jose Brea-del Castillo, Angela Gentile, Xavier Saez-Llorens, Abiel Mascarenas, Flor M. Munoz, Juan P. Torres, Liliana Vazquez, Marco A. Safadi, Carlos Espinal, Rolando Ulloa-Gutierrez, Monica Pujadas, Pio Lopez, Eduardo López-Medina, Octavio Ramilo
Publikováno v:
Frontiers in Pediatrics, Vol 11 (2023)
While the first 1,000 days of life are a critical period in child's development, limited information on the main determinants affecting this period in the Latin America and the Caribbean (LAC) region is available. Therefore, the Latin American Pediat
Externí odkaz:
https://doaj.org/article/286314c1dbb4400f86404745d35a1f79
Autor:
Maria L. Avila Agüero, Jose Brea Del Castillo, Luiza Helena Falleiros-Arlant, Eitan Berezín, Jose Cassio de Moraes, Carlos Torres-Martínez, Eduardo L. Lopez, María E. Castillo, Almudena Laris-Gonzalez, Fortino Solorzano, Angela Gentile, Juan Pablo Torres Torretti, Eduardo López-Medina
Publikováno v:
Expert Review of Vaccines, Vol 0, Iss 0 (2023)
Introduction The WHO 2030 Immunization Agenda (IA-2030) harmonizes immunization activity plans at community, national, regional and global levels. Additionally, medical societies play an important role. The Latin American Group of Experts on Infant I
Externí odkaz:
https://doaj.org/article/4a371e66fc1f43469fe67825be085bdc
Publikováno v:
Molecules, Vol 28, Iss 24, p 8107 (2023)
The identification of new modulators for Cannabinoid Receptors (CBRs) has garnered significant attention in drug discovery over recent years, owing to their manifold pathophysiological implications. In the context of hit identification, the availabil
Externí odkaz:
https://doaj.org/article/b984db540fcc45b38c1ff849fd3cbb3b
Autor:
Tzitzoglaki, Christina, Hoffmann, Anja, Turcu, Andreea L., Schmerer, Patrick, Ma, Chunlong, Laros, George, Liolios, Christos, José, Brea, Wang, Jun, Vázquez, Santiago, Schmidtke, Michaela, Kolocouris, Antonios
Publikováno v:
In European Journal of Medicinal Chemistry Reports December 2022 6
Autor:
Maris-Johanna Tahk, Tõnis Laasfeld, Elo Meriste, Jose Brea, Maria Isabel Loza, Maria Majellaro, Marialessandra Contino, Eddy Sotelo, Ago Rinken
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Dopamine receptors are G-protein-coupled receptors that are connected to severe neurological disorders. The development of new ligands targeting these receptors enables gaining a deeper insight into the receptor functioning, including binding mechani
Externí odkaz:
https://doaj.org/article/22db54a4222f4329a1d283cd834504c0