Výsledky vyhledávání - "Josane A. Lessa"

Synthesis and evaluation of copper(II) complexes with isoniazid-derived hydrazones as anticancer and antitubercular agents

Autor: Josane A. Lessa, Maria C.S. Lourenço, Gisele S. S. Firmino, Jackson A. L. C. Resende, Cláudia Pessoa, Marcus V. N. de Souza

Publikováno v: BioMetals. 29:953-963

In this study, the N,N,O metal chelator 2-pyridinecarboxaldehydeisonicotinoyl hydrazone (HPCIH, 1) and its derivatives 2-acetylpyridine-(HAPIH 2), 2-pyridineformamide-(HPAmIH, 3) and pyrazineformamide-(HPzAmIH, 4) were employed in the synthesis of fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28794639a9ed77a4485b4b87a5ea4681
https://doi.org/10.1007/s10534-016-9968-7

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Trace metal bioavailability in sediments from a reference site, Ribeira Bay, Brazil

Autor: Joana M. Santos, Josane A. Lessa, Wilson Machado, Janine M.M. Chiappetta

Publikováno v: Marine Pollution Bulletin. 106:395-399

Surface sediments were collected near potential contamination sources impacting Ribeira Bay (Brazil), a system considered as a 'reference site' for trace metals. Physicochemical properties (pH and Eh), grain size and concentrations of total organic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c2ea113e83fbc347ec5b982468f01a
https://doi.org/10.1016/j.marpolbul.2015.12.037

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Bismuth(III) complexes with pyrazineformamide thiosemicarbazones: Investigation on the antimicrobial and cytotoxic effects

Autor: Josane A. Lessa, Raquel S. Amim, Cláudia Pessoa, Jessica Cruz de Luca de Almeida, Maria C.S. Lourenço, Isolda C. Mendes

Publikováno v: Polyhedron. 189:114709

Complexes [Bi(PzAm4DH)Cl2] (1), [Bi(PzAm4M)Cl2] (2), [Bi(PzAm4E)Cl2] (3), [Bi(PzAm4Cy)Cl2]⋅3H2O (4) and [Bi(PzAm4Ph)Cl2] (5) were prepared with 2-pyrazineformamide- (HPzAm4DH, L1), N(4)-methyl-2-pyrazineformamide- (HPzAm4M, L2), N(4)-ethyl-2-pyrazi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ef5592464b987d6d2c2b48544a814ef5
https://doi.org/10.1016/j.poly.2020.114709

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Iron, copper, and manganese complexes with in vitro superoxide dismutase and/or catalase activities that keep Saccharomyces cerevisiae cells alive under severe oxidative stress

Autor: Karen V. Melo, Christiane Fernandes, Thales de P. Ribeiro, Marcos D. Pereira, Josane A. Lessa, Adolfo Horn, Roberto Weider de Assis Franco, Sarah S. Ferreira, Gerhard Schenk

Publikováno v: Free Radical Biology and Medicine. 80:67-76

Due to their aerobic lifestyle, eukaryotic organisms have evolved different strategies to overcome oxidative stress. The recruitment of some specific metalloenzymes such as superoxide dismutases (SODs) and catalases (CATs) is of great importance for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffc234ee731500ed8c09bb91673d2314
https://doi.org/10.1016/j.freeradbiomed.2014.12.005

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In vitro assessment of the cytotoxicity of Gallium(III) complexes with Isoniazid-Derived Hydrazones: Effects on clonogenic survival of HCT-116 cells

Autor: Zandora Hastenreiter, Stephanie C. André, Vanessa K. Campos, Elaine M. Souza-Fagundes, Josane A. Lessa, Mostafa A. L. Abdel-Salam, Gisele S. S. Firmino

Publikováno v: Inorganica Chimica Acta. 497:119079

Cancer cells have high iron demand to mediate their rapid proliferation. Aiming to obtain cytotoxic compounds with potential iron metabolism disturbance in malignant cells, [Ga(HAPIH)(APIH)](NO3)2⋅2H2O (1) and [Ga(HPAmIH)(PAmIH)](NO3)2⋅2H2O (2) w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::88f51923ef0fdf873505b9075afe67f6
https://doi.org/10.1016/j.ica.2019.119079

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Gallium(III) complexes with 2-acetylpyridine-derived thiosemicarbazones: antimicrobial and cytotoxic effects and investigation on the interactions with tubulin

Autor: Raquel Gouvêa dos Santos, Josane A. Lessa, Isolda C. Mendes, Heloisa Beraldo, Andreas Vogt, Billy W. Day, Adriano D. Andricopulo, Hikmat N. Daghestani, Lívia B. Salum, Marcella A. Soares

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Complexes [Ga(2Ac4pFPh)(2)]NO(3) (1), [Ga(2Ac4pClPh)(2)]NO(3) (2), [Ga(2Ac4pIPh)(2)]NO(3) (3), [Ga(2Ac4pNO(2)Ph)(2)]NO(3)·3H(2)O (4) and [Ga(2Ac4pT)(2)]NO(3) (5) were obtained with 2-acetylpyridine N(4)-para-fluorophenyl-(H2Ac4pFPh), 2-acetylpyridin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a0e00dfd4a74dfcdad8cf2a414bff1a
https://doi.org/10.1007/s10534-012-9603-1

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Gallium complexes as new promising metallodrug candidates

Autor: Josane A. Lessa, Heloisa Beraldo, Gabrieli L. Parrilha

Publikováno v: Inorganica Chimica Acta. 393:53-63

This is a review article on non-radioactive gallium(III) complexes as new promising metal-based drug candidates. A great variety of gallium(III) complexes and their pharmacological applications as anticancer and antimicrobial agents are described tog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::71f7997ff6a51d9c9c313a916adc6f6a
https://doi.org/10.1016/j.ica.2012.06.003

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Synthesis, Antitubercular and Anticancer Activities of p-nitrophenylethylenediamine-derived Schiff Bases

Autor: Raquel S, Amim, Cláudia, Pessoa, Maria C S, Lourenço, Marcus V N, de Souza, Josane A, Lessa

Publikováno v: Medicinal chemistry (Shariqah (United Arab Emirates)).

Schiff bases have been greatly studied in biological field due to their wide range of pharmacological activities, such as antitubercular and antitumour. In the search of novel antitubercular agents, several compounds containing pharmacophoric group o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::95c8758c2093cdf21d3e91010634d652
https://pubmed.ncbi.nlm.nih.gov/27823561

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Coordination of Thiosemicarbazones and Bis(thiosemicarbazones) to Bismuth(III) as a Strategy for the Design of Metal‐Based Antibacterial Agents

Autor: Lúcia T. Paradizzi, Heloisa Beraldo, Mariany de Fátima A. Carvalho, Sarah A. Siqueira, Josane A. Lessa, Débora C. Reis, Jeferson G. Da Silva, Nayane F. Silva

Publikováno v: Chemistry & Biodiversity. 9:1955-1966

Complexes [Bi(2Fo4Ph)Cl(2)] (1), [Bi(2Ac4Ph)Cl(2)] (2), [Bi(2Bz4Ph)Cl(2)] (3), [Bi(H(2)Gy3DH)Cl(3)] (4), [Bi(H(2)Gy4Et)(OH)(2)Cl] (5), and [Bi(H(2)Gy4Ph)Cl(3)] (6) were prepared with pyridine-2-carbaldehyde 4-phenylthiosemicarbazone (H2Fo4Ph), 1-(pyr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f172c1ff6f14acc387b368d770672416
https://doi.org/10.1002/cbdv.201100447

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N4-Phenyl-substituted 2-acetylpyridine thiosemicarbazones: Cytotoxicity against human tumor cells, structure–activity relationship studies and investigation on the mechanism of action

Autor: Heloisa Beraldo, Josane A. Lessa, Marcella A. Soares, Billy W. Day, Andreas Vogt, Adriano D. Andricopulo, Hikmat N. Daghestani, Lívia B. Salum, Raquel Gouvêa dos Santos, Jorge L. Pesquero, Jeferson G. Da Silva, Isolda C. Mendes, Willian R. Rocha

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

N(4)-Phenyl 2-acetylpyridine thiosemicarbazone (H2Ac4Ph; N-(phenyl)-2-(1-(pyridin-2-yl)ethylidene)hydrazinecarbothioamide) and its N(4)-ortho-, -meta- and -para-fluorophenyl (H2Ac4oFPh, H2Ac4mFPh, H2Ac4pFPh), N(4)-ortho-, -meta- and -para-chloropheny

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::569523fc96f93b069822d48519e3f118
https://doi.org/10.1016/j.bmc.2012.04.027

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