Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Jos van Nijnatten"'
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Akademický článek
A bronchial gene signature specific for severe COPD that is retained in the nose
Autor: Jos van Nijnatten, Alen Faiz, Wim Timens, Victor Guryev, Dirk-Jan Slebos, Karin Klooster, Jorine E. Hartman, Tessa Kole, David F. Choy, Arindam Chakrabarti, Michele Grimbaldeston, Carrie M. Rosenberger, Huib Kerstjens, Corry-Anke Brandsma, Maarten van den Berge
Publikováno v: ERJ Open Research, Vol 9, Iss 6 (2023)
Introduction A subset of COPD patients develops advanced disease with severe airflow obstruction, hyperinflation and extensive emphysema. We propose that the pathogenesis in these patients differs from mild–moderate COPD and is reflected by bronchi
Externí odkaz: https://doaj.org/article/f610066986744c4ca9c55fa72b5443c4
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2
Akademický článek
High miR203a-3p and miR-375 expression in the airways of smokers with and without COPD
Autor: Jos van Nijnatten, Corry-Anke Brandsma, Katrina Steiling, Pieter S. Hiemstra, Wim Timens, Maarten van den Berge, Alen Faiz
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Smoking is a leading cause of chronic obstructive pulmonary disease (COPD). It is known to have a significant impact on gene expression and (inflammatory) cell populations in the airways involved in COPD pathogenesis. In this study, we inves
Externí odkaz: https://doaj.org/article/eb471c8ae1f541389cd244622b95ec01
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4
Smoking induces shifts in cellular composition and transcriptome within the bronchial mucus barrier
Autor: Senani N. H. Rathnayake, Benedikt Ditz, Jos van Nijnatten, Tayyaba Sadaf, Philip M. Hansbro, Corry A. Brandsma, Wim Timens, Annemarie van Schadewijk, Peter S. Hiemstra, Nick H. T. ten Hacken, Brian Oliver, Huib A. M. Kerstjens, Maarten van den Berge, Alen Faiz
Publikováno v: Respirology, 28(2), 132-142. Wiley
Background and Objective: Smoking disturbs the bronchial-mucus-barrier. This study assesses the cellular composition and gene expression shifts of the bronchial-mucus-barrier with smoking to understand the mechanism of mucosal damage by cigarette smo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8f40a4ebd339fbdc5ca53ca46922d0
https://pubmed.ncbi.nlm.nih.gov/36414410
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6
Identification of asthma associated microRNAs in bronchial biopsies
Autor: Corry-Anke Brandsma, Maarten van den Berge, Karen Affleck, Alen Faiz, Tania Maes, Ilse M. Boudewijn, Mirjam P Roffel, Ken R. Bracke, Jos van Nijnatten, Irene H. Heijink, Corneel J Vermeulen, Wim Timens, Antoon J. M. van Oosterhout
Publikováno v: European Respiratory Journal, 59(3):2101294. EUROPEAN RESPIRATORY SOC JOURNALS LTD
BackgroundChanges in microRNA (miRNA) expression can contribute to the pathogenesis of many diseases, including asthma. We aimed to identify miRNAs that are differentially expressed between asthma patients and healthy controls, and explore their asso
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d7956237b7afd5b819d42cc69cab9be
https://hdl.handle.net/10453/165909
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8
MicroRNA profiling in bronchial biopsies of asthma patients
Autor: Mirjam P. Roffel, Ilse M. Boudewijn, Jos Van Nijnatten, Corneel J. Vermeulen, Antoon J.M. Van Oosterhout, Karen Affleck, Ken R. Bracke, Tania Maes, Irene H. Heijink, Corry-Anke Brandsma, Maarten Van Den Berge
Publikováno v: European Respiratory Journal, 56. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Alterations in miRNA expression may play a role in the pathogenesis of asthma. Our aim was to identify miRNAs that are differentially expressed in bronchial biopsies of asthmatics compared to healthy controls and to explore their association with cli
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a3f306384e57ca85d5a880f7770ed
https://hdl.handle.net/11370/68dce59e-979f-42f8-9471-49d353ef0b14
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9
Changes in DNA methylation after corticosteroids treatment in COPD patients
Autor: Corry-Anke Brandsma, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Jos van Nijnatten, Alen Faiz
Publikováno v: European Respiratory Journal, 56. EUROPEAN RESPIRATORY SOC JOURNALS LTD
Introduction: Inhaled corticosteroids (ICS) are used to reduce inflammation in COPD and have shown to reduce the decline of FEV1 in a subset of COPD patients, but its effects on the methylome remain unknown. Aims: This project aims to investigate the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7e502cad52d4b497038cd98364630b2
https://doi.org/10.1183/13993003.congress-2020.4783
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10
iFUSE: integrated fusion gene explorer
Autor: Ines Teles Alves, Saskia Hiltemann, Andrew P. Stubbs, Elizabeth A. McClellan, Jos van Nijnatten, Ivo Palli, Guido Jenster, Thomas A Hartjes, Peter J. van der Spek, Sebastiaan Horsman, Jan Trapman
Publikováno v: Bioinformatics
Bioinformatics, 29(13), 1700-1701. Oxford University Press
Summary: We present iFUSE (integrated fusion gene explorer), an online visualization tool that provides a fast and informative view of structural variation data and prioritizes those breaks likely representing fusion genes. This application uses calc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b1cb893412927156184a0226d189f7
https://doi.org/10.1093/bioinformatics/btt252
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