Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Jos Van Rijssel"'
Autor:
Alina Klems, Jos van Rijssel, Anne S. Ramms, Raphael Wild, Julia Hammer, Melanie Merkel, Laura Derenbach, Laetitia Préau, Rabea Hinkel, Irina Suarez-Martinez, Stefan Schulte-Merker, Ramon Vidal, Sascha Sauer, Riikka Kivelä, Kari Alitalo, Christian Kupatt, Jaap D. van Buul, Ferdinand le Noble
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
Arterial flow regulates artery diameter but other mechanisms may also affect this. Here, the authors show that the guanine nucleotide exchange factor Trio and GTPases Rac1 and RhoG, triggers F-actin remodeling in arterial endothelial cells, independe
Externí odkaz:
https://doaj.org/article/766d4ed327d94a5ba84fee477abb7f31
Autor:
Janine JG Arts, Eike K Mahlandt, Max LB Grönloh, Lilian Schimmel, Ivar Noordstra, Emma Gordon, Abraham CI van Steen, Simon Tol, Barbara Walzog, Jos van Rijssel, Martijn A Nolte, Marten Postma, Satya Khuon, John M Heddleston, Eric Wait, Teng Leong Chew, Mark Winter, Eloi Montanez, Joachim Goedhart, Jaap D van Buul
Publikováno v:
eLife, Vol 10 (2021)
Upon inflammation, leukocytes rapidly transmigrate across the endothelium to enter the inflamed tissue. Evidence accumulates that leukocytes use preferred exit sites, alhough it is not yet clear how these hotspots in the endothelium are defined and h
Externí odkaz:
https://doaj.org/article/e8c403c2145749c68b603d43a3547e87
Autor:
Janine J. G. Arts, Eike K. Mahlandt, Lilian Schimmel, Max L. B. Grönloh, Sanne van der Niet, Bart J. A. M. Klein, Mar Fernandez-Borja, Daphne van Geemen, Stephan Huveneers, Jos van Rijssel, Joachim Goedhart, Jaap D. van Buul
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
An inflammatory response requires leukocytes to migrate from the circulation across the vascular lining into the tissue to clear the invading pathogen. Whereas a lot of attention is focused on how leukocytes make their way through the endothelial mon
Externí odkaz:
https://doaj.org/article/c305759e1af542afa349976b10539ac8
Autor:
Timo Rademakers, Marieke Goedhart, Mark Hoogenboezem, Alexander García Ponce, Jos van Rijssel, Maryna Samus, Michael Schnoor, Stefan Butz, Stephan Huveneers, Dietmar Vestweber, Martijn A. Nolte, Carlijn Voermans, Jaap D. van Buul
Publikováno v:
Haematologica, Vol 105, Iss 12 (2020)
Bone marrow endothelium plays an important role in the homing of hematopoietic stem and progenitor cells upon transplantation, but surprisingly little is known on how the bone marrow endothelial cells regulate local permeability and hematopoietic ste
Externí odkaz:
https://doaj.org/article/1d4bdbd49d9148a4be4889ee5c472fdd
Autor:
Lilian Schimmel, Miesje van der Stoel, Carmela Rianna, Anne-Marieke van Stalborch, Aafke de Ligt, Mark Hoogenboezem, Simon Tol, Jos van Rijssel, Robert Szulcek, Harm Jan Bogaard, Patrick Hofmann, Reinier Boon, Manfred Radmacher, Vivian de Waard, Stephan Huveneers, Jaap D. van Buul
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3115-3124 (2018)
Summary: Leukocytes follow the well-defined steps of rolling, spreading, and crawling prior to diapedesis through endothelial cells (ECs). We found increased expression of DLC-1 in stiffness-associated diseases like atherosclerosis and pulmonary arte
Externí odkaz:
https://doaj.org/article/5f17c77e78704ee38964331f2e1d6ba9
Autor:
Niels J. M. Verstegen, Peter-Paul A. Unger, Julia Z. Walker, Benoit P. Nicolet, Tineke Jorritsma, Jos van Rijssel, Robbert M. Spaapen, Jelle de Wit, Jaap D. van Buul, Anja ten Brinke, S. Marieke van Ham
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Growing evidence indicate that large antigen-containing particles induce potent T cell-dependent high-affinity antibody responses. These responses require large particle internalization after recognition by the B cell receptor (BCR) on B cells. Howev
Externí odkaz:
https://doaj.org/article/5d430dc73d35412da79d6bdd7d01eb74
Autor:
Niels Heemskerk, Lilian Schimmel, Chantal Oort, Jos van Rijssel, Taofei Yin, Bin Ma, Jakobus van Unen, Bettina Pitter, Stephan Huveneers, Joachim Goedhart, Yi Wu, Eloi Montanez, Abigail Woodfin, Jaap D. van Buul
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
Endothelial cells can support leukocyte extravasation without causing vascular leakage, but the exact mechanism underlying this process has not been fully elucidated. Here the authors show that it is regulated through actomyosin-based endothelial por
Externí odkaz:
https://doaj.org/article/6c3133e60cd84e1f9874b018a721bd0a
Autor:
Jos Van Rijssel, Ilse Timmerman, Floris P. J. Van Alphen, Mark Hoogenboezem, Olexandr Korchynskyi, Dirk Geerts, Judy Geissler, Kris A. Reedquist, Hans W. M. Niessen, Jaap D. Van Buul
Publikováno v:
Biology Open, Vol 2, Iss 6, Pp 569-579 (2013)
Summary Inflammation is characterized by endothelium that highly expresses numerous adhesion molecules to trigger leukocyte extravasation. Central to this event is increased gene transcription. Small Rho-GTPases not only control the actin cytoskeleto
Externí odkaz:
https://doaj.org/article/4967d438560e4410a565144eb084f8ef
Publikováno v:
PLoS ONE, Vol 7, Iss 1, p e29912 (2012)
The guanine-nucleotide exchange factor Trio encodes two DH-PH domains that catalyze nucleotide exchange on Rac1, RhoG and RhoA. The N-terminal DH-PH domain is known to activate Rac1 and RhoG, whereas the C-terminal DH-PH domain can activate RhoA. The
Externí odkaz:
https://doaj.org/article/3ae272e44afc4683861c4904208a2605
Autor:
Jaap D van Buul, Jos van Rijssel, Floris P J van Alphen, Mark Hoogenboezem, Simon Tol, Kees A Hoeben, Jan van Marle, Erik P J Mul, Peter L Hordijk
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11336 (2010)
BackgroundDuring transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukoc
Externí odkaz:
https://doaj.org/article/7193af2812dc4e36a4aa181fd4b28836