Výsledky vyhledávání - "Jos P. Varghese"

Branched Multifunctional Polyether Polyketals: Variation of Ketal Group Structure Enables Unprecedented Control over Polymer Degradation in Solution and within Cells

Autor: Jasmine L. Hamilton, Jayaprakash K. Narayanannair, Rajesh K. Kainthan, Sonja Horte, Benjamin F.L. Lai, Jos P. Varghese, Jayachandran N. Kizhakkedathu, Rajesh A. Shenoi, Muthiah Manoharan, Kallanthottathil G. Rajeev

Publikováno v: Journal of the American Chemical Society. 134:14945-14957

Multifunctional biocompatible and biodegradable nanomaterials incorporating specific degradable linkages that respond to various stimuli and with defined degradation profiles are critical to the advancement of targeted nanomedicine. Herein we report,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5269f30de39e413e3ee90b2160a52f1a
https://doi.org/10.1021/ja305080f

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Non-Nucleoside Building Blocks for Copper-Assisted and Copper-Free Click Chemistry for the Efficient Synthesis of RNA Conjugates

Autor: K. N. Jayaprakash, Muthiah Manoharan, Kallanthottathil G. Rajeev, Martin Maier, Jos P. Varghese, David Butler, Chang Geng Peng

Publikováno v: Organic Letters. 12:5410-5413

Novel non-nucleoside alkyne monomers compatible with oligonucleotide synthesis were designed, synthesized, and efficiently incorporated into RNA and RNA analogues during solid-phase synthesis. These modifications allowed site-specific conjugation of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e17ce4e74f124737c09ba9e5945dbe83
https://doi.org/10.1021/ol102205j

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New regio-, stereo-, diastereo- and enantioselective one-pot reactions mediated by organometallic derivatives

Autor: Adi Abramovitch, Helena Chechik, Jos P. Varghese, Swapan Majumdar, Nicka Chinkov, Genia Sklute, Ilan Marek, Deborah Amsallem

Publikováno v: Pure and Applied Chemistry. 76:517-535

In the first part of the lecture, we will discuss the one-pot preparation of chiral homoallylic alcohol and amine derivatives by a copper-catalyzed four-component reaction. In this process, three new carbon-carbon bonds as well as a quaternary and a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::eb76421885cbb9001015e6c8c33c390f
https://doi.org/10.1351/pac200476030517

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α-Sulfinyl Carbanions as A New Source of Olefins

Autor: Jos P. Varghese, Ilan Marek, Adi Abramovitch

Publikováno v: Organic Letters. 6:621-623

[reaction: see text] Secondary alpha-lithiosulfinyl carbanions react either intermolecularly, after transmetalation into an organocopper derivative in an S(N)2-type process with zinc carbenoid, or intramolecularly via higher-order zincate to give, th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c08c2b7dfdf7c14978420c679a21b86
https://doi.org/10.1021/ol036450o

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Cobalt-Catalyzed Selective Oxidation of Benzylic and Allylic Alcohols by Tert. Butyl Hydroperoxide

Autor: Suresh Iyer, Jos P. Varghese

Publikováno v: Synthetic Communications. 25:2261-2266

The selective oxidation of benzylic and allylic alcohols by tert. BuOOH was catalysed by cobalt complexes.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77535ef93e865c1196baffb546a99593
https://doi.org/10.1080/00397919508011781

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Pd-Catalysed Regiospecific Reductive Ring Opening of Epoxides and Glycidic Esters

Autor: Suresh Iyer, Arumugam Sudalai, Jos P. Varghese

Publikováno v: Synthetic Communications. 25:2267-2273

The regiospecific ring opening of epoxides was achieved by Pd-catalysed transfer hydrogenolysis using ammonium formate as hydrogen source.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a915ffec95633b12e5b8b17f72fc88c8
https://doi.org/10.1080/00397919508011782

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