Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Jos G. A. Smits"'
1
Akademický článek
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Autor: Niclas Fester, Elisabeth Zielonka, Jakob Goldmann, Ann-Sophie Frombach, Uta Müller-Kuller, Niklas Gutfreund, Kristina Riegel, Jos G. A. Smits, Enrico Schleiff, Krishnaraj Rajalingam, Huiqing Zhou, Stefan Simm, Volker Dötsch
Publikováno v: Cell Death and Disease, Vol 13, Iss 3, Pp 1-10 (2022)
Abstract Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations a
Externí odkaz: https://doaj.org/article/841bc32e7e0f40afa499d067f945af6a
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2
Akademický článek
Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
Autor: Giulia Franciosa, Jos G. A. Smits, Sonia Minuzzo, Ana Martinez-Val, Stefano Indraccolo, Jesper V. Olsen
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and ident
Externí odkaz: https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a
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3
Akademický článek
Identification of the regulatory circuit governing corneal epithelial fate determination and disease.
Autor: Jos G A Smits, Dulce Lima Cunha, Maryam Amini, Marina Bertolin, Camille Laberthonnière, Jieqiong Qu, Nicholas Owen, Lorenz Latta, Berthold Seitz, Lauriane N Roux, Tanja Stachon, Stefano Ferrari, Mariya Moosajee, Daniel Aberdam, Nora Szentmary, Simon J van Heeringen, Huiqing Zhou
Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002336 (2023)
The transparent corneal epithelium in the eye is maintained through the homeostasis regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on epidermal keratinocytes for renewal. Despite their cellular similarities, the prec
Externí odkaz: https://doaj.org/article/c523fd35c9044ca68bcfe92e2129b496
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4
Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures
Autor: Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo
Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2893db770522143b54c11e4bc1efc4
https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a
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5
Enhanced pro-apoptosis gene signature following the activation of TAp63α in oocytes upon γ irradiation
Autor: Niclas, Fester, Elisabeth, Zielonka, Jakob, Goldmann, Ann-Sophie, Frombach, Uta, Müller-Kuller, Niklas, Gutfreund, Kristina, Riegel, Jos G A, Smits, Enrico, Schleiff, Krishnaraj, Rajalingam, Huiqing, Zhou, Stefan, Simm, Volker, Dötsch
Publikováno v: Cell deathdisease. 13(3)
Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations are, there
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::97801f03dabba50eb2b5e2fdf4bbf51d
https://pubmed.ncbi.nlm.nih.gov/35246516
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6
Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis
Autor: Jos G. A. Smits, Hanna Niehues, Huiqing Zhou, Jieqiong Qu
Publikováno v: Journal of Visualized Experiments, 159
Journal of Visualized Experiments
Human primary keratinocytes are often used as in vitro models for studies on epidermal differentiation and related diseases. Methods have been reported for in vitro differentiation of keratinocytes cultured in two-dimensional (2D) submerged manners u
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b874815ba1f4eaa5c5da2cdee35897
https://hdl.handle.net/2066/224066
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7
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model
Autor: Guoqiang Yi, Branco M. H. Heuts, Francesco Ferrari, Jan Jacob Schuringa, Eva M. Janssen-Megens, Esther Tijchon, Amit Mandoli, Jos G. A. Smits, Bowon Kim, Falco Wijnen, Joost H.A. Martens
Publikováno v: PLoS One, 14
PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
PLoS One, 14, 12
PLoS ONE
PLoS ONE, 14(12):0226435. PUBLIC LIBRARY SCIENCE
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca67d382a738dc1f542cb251b0e26df
http://hdl.handle.net/2066/219175
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9
Akademický článek
The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model.
Autor: Esther Tijchon, Guoqiang Yi, Amit Mandoli, Jos G A Smits, Francesco Ferrari, Branco M H Heuts, Falco Wijnen, Bowon Kim, Eva M Janssen-Megens, Jan Jacob Schuringa, Joost H A Martens
Publikováno v: PLoS ONE, Vol 14, Iss 12, p e0226435 (2019)
Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell lines and patient derived AMLs that also carry additio
Externí odkaz: https://doaj.org/article/c2d8cbfea6314d7495286f1c3efb457d
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