Identification of the regulatory circuit governing corneal epithelial fate determination and disease.

Autor: Jos G A Smits, Dulce Lima Cunha, Maryam Amini, Marina Bertolin, Camille Laberthonnière, Jieqiong Qu, Nicholas Owen, Lorenz Latta, Berthold Seitz, Lauriane N Roux, Tanja Stachon, Stefano Ferrari, Mariya Moosajee, Daniel Aberdam, Nora Szentmary, Simon J van Heeringen, Huiqing Zhou

Publikováno v: PLoS Biology, Vol 21, Iss 10, p e3002336 (2023)

The transparent corneal epithelium in the eye is maintained through the homeostasis regulated by limbal stem cells (LSCs), while the nontransparent epidermis relies on epidermal keratinocytes for renewal. Despite their cellular similarities, the prec

Externí odkaz: https://doaj.org/article/c523fd35c9044ca68bcfe92e2129b496

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Autor: Giulia Franciosa, Jos G. A. Smits, Sonia Minuzzo, Ana Martinez-Val, Stefano Indraccolo, Jesper V. Olsen

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

NOTCH1 is a driver of T-cell acute lymphoblastic leukemia that can be inhibited by γ-secretase inhibitors (GSIs), but their clinical efficacy is limited. Here, the authors compare the phosphoproteomes of GSI resistant and sensitive models, and ident

Externí odkaz: https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a

Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures

Autor: Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9

Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f2893db770522143b54c11e4bc1efc4
https://doaj.org/article/fb005241b37140cb8b362c5dec3d935a

Characterization of In Vitro Differentiation of Human Primary Keratinocytes by RNA-Seq Analysis

Autor: Jos G. A. Smits, Hanna Niehues, Huiqing Zhou, Jieqiong Qu

Publikováno v: Journal of Visualized Experiments, 159
Journal of Visualized Experiments

Human primary keratinocytes are often used as in vitro models for studies on epidermal differentiation and related diseases. Methods have been reported for in vitro differentiation of keratinocytes cultured in two-dimensional (2D) submerged manners u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b874815ba1f4eaa5c5da2cdee35897
https://hdl.handle.net/2066/224066

The leukemic oncogene AML1-eto blocks differentiation by altering the transcriptome and epigenome during human iPSC-based hematopoietic development

Autor: Esther Tijchon, Jos G. A. Smits, Amit Mandoli, Francesco Ferrari, Falco Wijnen, Joost H.A. Martens

Publikováno v: Experimental Hematology. 53:S79

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc4a975e60e84322549c1f38068f4fb
https://doi.org/10.1016/j.exphem.2017.06.172