Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Jos Cals"'
Autor:
Matthew H. Daniels, Sunil Nagpal, Blair T. Lapointe, Jos Cals, Mario van der Stelt, Vladimir Simov, Willem Jan Karstens, Sujal V. Deshmukh, Kenneth Jay Barr, J. Richard Miller, Hans van Eenenaam, Craig C. Correll, John Maclean, Laxminarayan G Hegde, Lily Y. Moy, B. Wesley Trotter, Rachel L. Palte, Janice D Woodhouse, Nunzio Sciammetta, Gopal Parthasarathy, Heidi Ferguson, Rita Azevedo, Hongjun Zhang, Arthur Oubrie, Neville J. Anthony
Publikováno v:
ACS Medicinal Chemistry Letters. 11:114-119
The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and affects th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::927a9a20903f38d39770d2e5897d3e47
https://doi.org/10.1021/acsmedchemlett.9b00431
https://doi.org/10.1021/acsmedchemlett.9b00431
Autor:
Hongjun, Zhang, Blair T, Lapointe, Neville, Anthony, Rita, Azevedo, Jos, Cals, Craig C, Correll, Matthew, Daniels, Sujal, Deshmukh, Hans, van Eenenaam, Heidi, Ferguson, Laxminarayan G, Hegde, Willem Jan, Karstens, John, Maclean, J Richard, Miller, Lily Y, Moy, Vladimir, Simov, Sunil, Nagpal, Arthur, Oubrie, Rachel L, Palte, Gopal, Parthasarathy, Nunzio, Sciammetta, Mario, van der Stelt, Janice D, Woodhouse, B Wesley, Trotter, Kenneth, Barr
Publikováno v:
ACS Med Chem Lett
[Image: see text] The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b04108fd54b05ba3642d5229b4061176
https://pubmed.ncbi.nlm.nih.gov/32071676
https://pubmed.ncbi.nlm.nih.gov/32071676
Autor:
Silvia Broeders-Josten, Julia Oosterom, Jean E. Cottney, Antoon A. van der Doelen, Jeroen A.D.M. de Roos, Martin van Tilborg, Marcel Hermkens, Jos Cals, Jan P. G. Klomp, Vera de Kimpe, Angela King, Mario van der Stelt, James Baker, Susan Boyce, Ilse Pols-de Rooij
Publikováno v:
Journal of medicinal chemistry. 54(20)
Here, we report the identification and optimization of 1-(4-(pyridin-2-yl)benzyl)imidazolidine-2,4-dione derivatives as a novel chemotype with selective cannabinoid CB2 receptor agonist activity. 1 is a potent and selective cannabinoid CB2 receptor a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54f473ef139387f958fde08febf68815
https://pubmed.ncbi.nlm.nih.gov/21923175
https://pubmed.ncbi.nlm.nih.gov/21923175