Zobrazeno 1 - 10
of 321
pro vyhledávání: '"Jos C S, Kleinjans"'
Autor:
Vidya Chandrasekaran, Giada Carta, Daniel da Costa Pereira, Rajinder Gupta, Cormac Murphy, Elisabeth Feifel, Georg Kern, Judith Lechner, Anna Lina Cavallo, Shailesh Gupta, Florian Caiment, Jos C. S. Kleinjans, Gerhard Gstraunthaler, Paul Jennings, Anja Wilmes
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
Abstract The renal proximal tubule is responsible for re-absorption of the majority of the glomerular filtrate and its proper function is necessary for whole-body homeostasis. Aging, certain diseases and chemical-induced toxicity are factors that con
Externí odkaz:
https://doaj.org/article/cabcf3e0db84468c83c49d606b6f2e22
Autor:
Sacha Bohler, Xiaosong Liu, Julian Krauskopf, Florian Caiment, Jiri Aubrecht, Gerry A. F. Nicolaes, Jos C. S. Kleinjans, Jacco J. Briedé
Publikováno v:
Clinical and Translational Science, Vol 12, Iss 6, Pp 609-616 (2019)
Four complementary approaches were used to investigate acetaminophen overdose as a risk factor for Parkinson's disease (PD). Circulating microRNAs (miRNAs) serum profiles from acetaminophen‐overdosed patients were compared with patients with termin
Externí odkaz:
https://doaj.org/article/c4299ed8807e4bb1b34aa2f0ebac37f4
Autor:
Jean-Pierre Bourguignon, Anne-Simone Parent, Jos C. S. Kleinjans, Tim S. Nawrot, Greet Schoeters, Nicolas Van Larebeke
Publikováno v:
Environmental Health, Vol 17, Iss 1, Pp 1-11 (2018)
Abstract Background The regulatory management of chemicals and toxicants in the EU addresses hundreds of different chemicals and health hazards individually, one by one. An issue is that, so far, the possible interactions among chemicals or hazards a
Externí odkaz:
https://doaj.org/article/01631f14ec3c46e7ad41a33947688b59
Autor:
Wim H. De Jong, Danyel Jennen, Peter H. J. Keizers, Hennie M. Hodemaekers, Jolanda P. Vermeulen, Frank Bakker, Paul Schwillens, Marcel van Herwijnen, Marlon Jetten, Jos C. S. Kleinjans, Robert E. Geertsma, Rob J. Vandebriel
Publikováno v:
International journal of molecular sciences, 23(13):7275. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7275
International Journal of Molecular Sciences; Volume 23; Issue 13; Pages: 7275
Resorbable tissue fillers for aesthetic purposes can induce severe complications including product migration, late swelling, and inflammatory reactions. The relation between product characteristics and adverse effects is not well understood. We hypot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d0a7ab31dd1704f69f249822a95544
http://hdl.handle.net/10029/626514
http://hdl.handle.net/10029/626514
Autor:
Alice Limonciel, Simone G. van Breda, Xiaoqi Jiang, Gregory D. Tredwell, Anja Wilmes, Lydia Aschauer, Alexandros P. Siskos, Agapios Sachinidis, Hector C. Keun, Annette Kopp-Schneider, Theo M. de Kok, Jos C. S. Kleinjans, Paul Jennings
Publikováno v:
Frontiers in Genetics, Vol 9 (2018)
The discovery of the epigenetic regulation of transcription has provided a new source of mechanistic understanding to long lasting effects of chemicals. However, this information is still seldom exploited in a toxicological context and studies of che
Externí odkaz:
https://doaj.org/article/3d4ec61caa4f42d49159c0721f28c25c
Autor:
Almudena Espín-Pérez, Chris Portier, Marc Chadeau-Hyam, Karin van Veldhoven, Jos C S Kleinjans, Theo M C M de Kok
Publikováno v:
PLoS ONE, Vol 13, Iss 8, p e0202947 (2018)
Batch effects are technical sources of variation introduced by the necessity of conducting gene expression analyses on different dates due to the large number of biological samples in population-based studies. The aim of this study is to evaluate the
Externí odkaz:
https://doaj.org/article/f2555e9e22044953913cc472ab568536
Autor:
Danyel G. J. Jennen, Marcel van Herwijnen, Marlon Jetten, Rob J. Vandebriel, Peter Keizers, Robert E. Geertsma, Wim H. de Jong, Jos C. S. Kleinjans
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 13046
International journal of molecular sciences, 23(21):13046. Multidisciplinary Digital Publishing Institute (MDPI)
International journal of molecular sciences, 23(21):13046. Multidisciplinary Digital Publishing Institute (MDPI)
Usage of injectable dermal fillers applied for aesthetic purposes has extensively increased over the years. As such, the number of related adverse reactions has increased, including patients showing severe complications such as product migration, top
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c43434dbb098fb6342de0c7e3141bf
https://cris.maastrichtuniversity.nl/en/publications/50ee1de2-97c3-4cef-82be-65ed4b7be470
https://cris.maastrichtuniversity.nl/en/publications/50ee1de2-97c3-4cef-82be-65ed4b7be470
Autor:
Ramona Nudischer, Adrian Roth, Vanessa Baier, Lars M. Blank, José V. Castell, Jens M. Kelm, Annika R. P. Schneider, Florian Caiment, Hans Gmuender, Christoph Thiel, Lars Kuepfer, Wolfgang Moritz, Yannick Schrooders, Henrik Cordes, Jos C. S. Kleinjans, Christian Trautwein, Timo Wittenberger, Olivia Clayton, Ulf P. Neumann
Publikováno v:
Clinical pharmacology & therapeutics : CPT 110(5), 1293-1301 (2021). doi:10.1002/cpt.2406
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Clinical Pharmacology & Therapeutics, 110(5), 1293-1301. Wiley
CLINICAL PHARMACOLOGY & THERAPEUTICS
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
We present a generic workflow combining physiology-based computational modeling and in vitro data to assess the clinical cholestatic risk of different drugs systematically. Changes in expression levels of genes involved in the enterohepatic circulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2bb897e70f87a57b55a2225fb471753
https://doi.org/10.1002/cpt.2406
https://doi.org/10.1002/cpt.2406
Autor:
Johanna Vappiani, Terezinha de Souza, Theo M. de Kok, Luke Coyle, Julio Saez-Rodriguez, Danyel Jennen, Daniel C. Sévin, D. F. Rodrigues, Seung-Wook Chung, Matteo Di Piazza, Bram Herpers, Attila Gábor, Mian Zhang, Anthony M. Lynch, Jos C. S. Kleinjans, Sofia Ferreira
Publikováno v:
Archives of Toxicology
Archives of Toxicology, 95(8), 2691-2718. Springer
Archives of Toxicology, 95(8), 2691-2718. Springer
5-Fluorouracil (5-FU) is a widely used chemotherapeutical that induces acute toxicity in the small and large intestine of patients. Symptoms can be severe and lead to the interruption of cancer treatments. However, there is limited understanding of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ac9c066722eb245b2e70fe09b71ed5
https://doi.org/10.1007/s00204-021-03092-2
https://doi.org/10.1007/s00204-021-03092-2
Publikováno v:
Frontiers in Genetics, Vol 8 (2017)
Perturbation of biological networks is often observed during exposure to xenobiotics, and the identification of disturbed processes, their dynamic traits, and dose–response relationships are some of the current challenges for elucidating the mechan
Externí odkaz:
https://doaj.org/article/f3d07cc8485643bf9c9fb31e6fcd019e