Zobrazeno 1 - 10
of 35
pro vyhledávání: '"JoséM. Musacchio"'
Publikováno v:
Brain Research. 826:157-171
Receptor protein tyrosine phosphatases (RPTPs) comprise a family of proteins that feature intracellular phosphatase domains and an ectodomain with putative ligand-binding motifs. Several RPTPs are expressed in the brain, including RPTP-kappa which pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b29aed9f7cef78f67503ac1f5f1e40f
https://doi.org/10.1016/s0006-8993(99)01179-8
https://doi.org/10.1016/s0006-8993(99)01179-8
Publikováno v:
Journal of Neuroscience Research. 44:199-215
In situ hybridization and Northern analysis demonstrate that the three splicing variants of RPTP-β have different spatial and temporal patterns of expression in the developing brain. The 9.5-kb and 6.4-kb transcripts, which encode transmembrane prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b14ad83f47c2ad4bcd1975a9d8ae010
https://doi.org/10.1002/(sici)1097-4547(19960501)44:3<199::aid-jnr1>3.0.co
https://doi.org/10.1002/(sici)1097-4547(19960501)44:3<199::aid-jnr1>3.0.co
Autor:
Peter Canoll, Ricardo Martinez, Herman Moreno, JoséM. Musacchio, Joseph Schlessinger, Bernardo Rudy, Elior Peles, Sima Lev, Gregory D. Plowman
Publikováno v:
Nature. 376:737-745
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470f757ab0c7a73bf7980e39770714ff
https://doi.org/10.1038/376737a0
https://doi.org/10.1038/376737a0
Publikováno v:
Journal of Neuroscience Research. 41:297-310
The expression of receptor protein tyrosine phosphatase-sigma (RPTP-sigma) mRNA during rat development was examined by Northern blot and in situ hybridization analyses. Northern blot analysis revealed that the two transcripts (5.7 kb and 6.9 kb) had
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17e8515c615619269ed1b3847f3a57c1
https://doi.org/10.1002/jnr.490410303
https://doi.org/10.1002/jnr.490410303
Autor:
JoséM. Musacchio, Peter Canoll, Joseph Schlessinger, Joan B. Levy, Michelle E. Ehrlich, Olli Silvennoinen, Jan Sap, Gilad Barnea
Publikováno v:
Developmental Brain Research. 75:293-298
Analysis of the localization of receptor-type protein tyrosine phosphatase-beta (RPTP-beta) by in situ hybridization and immunocytochemistry indicates that it is predominantly expressed in the developing central nervous system (CNS). RPTP-beta is hig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4442a185d940539952c72dd5b4af772
https://doi.org/10.1016/0165-3806(93)90035-9
https://doi.org/10.1016/0165-3806(93)90035-9
Publikováno v:
Europe PubMed Central
We describe a new member of the receptor protein tyrosine phosphatase family, R-PTP-kappa, cDNA cloning predicts that R-PTP-kappa is synthesized from a precursor protein of 1,457 amino acids. Its intracellular domain displays the classical tandemly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773f9b662b7af8a417738c04d8f3acb4
https://doi.org/10.1128/mcb.13.5.2942-2951.1993
https://doi.org/10.1128/mcb.13.5.2942-2951.1993
Publikováno v:
Life Sciences. 48:543-550
The DM 1 σ 1 site binds dextromethorphan (DM) and σ receptor ligands. The broad binding specificity of this site and its peculiar subcellular distribution prompted us to explore the possibility that this site is a member of the cytochrome P-450 sup
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d22083630ef8fb436724258d264f3ac3
https://doi.org/10.1016/0024-3205(91)90469-r
https://doi.org/10.1016/0024-3205(91)90469-r
Publikováno v:
European journal of pharmacology. 254(3)
The s.c. administration of a single dose of 0.1 mg/kg of reduced haloperidol to guinea pigs produced a marked inhibition of the binding of [3H]dextromethorphan and [3H]3-(3-hydroxyphenyl)-N-(n-propyl)piperidine ([3H](+)-3-PPP) to brain. The inhibitio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf48b4a706006ece845c2f53ee53e12
https://pubmed.ncbi.nlm.nih.gov/8013558
https://pubmed.ncbi.nlm.nih.gov/8013558
Autor:
Hai Yan, Albert Grossman, Olli Silvennoinen, JoséM. Musacchio, Joseph Schlessinger, K. Mossie, Hong Wang, Peter D'Eustachio
Publikováno v:
Europe PubMed Central
A novel transmembrane receptor protein tyrosine phosphatase-sigma (RPTP-sigma) was cloned from a rat brain stem cDNA library. The extracellular segment of one form of RPTP-sigma contains 824 amino acids and is composed of three immunoglobulin-like an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9214001024876aadfbd313280806f4
https://pubmed.ncbi.nlm.nih.gov/8227050
https://pubmed.ncbi.nlm.nih.gov/8227050
Autor:
JoséM. Musacchio, Guang-Zhao Zhou
Publikováno v:
European journal of pharmacology. 206(4)
Computer-assisted, simultaneous analysis of self- and cross-displacement experiments demonstrated the existence of several binding sites in guinea pig brain for dextromethorphan, (+)-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine ((+)-3-PPP), and 1,3-di-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8e9e0a958fe9f8b4f179ade6848b43
https://pubmed.ncbi.nlm.nih.gov/1655487
https://pubmed.ncbi.nlm.nih.gov/1655487