New fluorogenic probes for neutral and alkaline ceramidases

Autor: Mireia Casasampere, Núria Bielsa, Daniel Riba, Laura Bassas, Ruijuan Xu, Cungui Mao, Gemma Fabriàs, José-Luis Abad, Antonio Delgado, Josefina Casas

Publikováno v: Journal of Lipid Research, Vol 60, Iss 6, Pp 1174-1181 (2019)

New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported. While none of the new probes were superior to the known RBM14C12 as acid ceramidase substrates, the corresponding nervo

Externí odkaz: https://doaj.org/article/048c0511ba6143f3ae222eeae22fc56c

Dose-dependent improvement of cardiac function in a swine model of acute myocardial infarction after intracoronary administration of allogeneic heart-derived cells

Autor: Veronica Crisostomo, Claudia Baez, José Luis Abad, Belén Sanchez, Virginia Alvarez, Rosalba Rosado, Guadalupe Gómez-Mauricio, Olivier Gheysens, Virginia Blanco-Blazquez, Rebeca Blazquez, José Luis Torán, Javier G. Casado, Susana Aguilar, Stefan Janssens, Francisco M. Sánchez-Margallo, Luis Rodriguez-Borlado, Antonio Bernad, Itziar Palacios

Publikováno v: Stem Cell Research & Therapy, Vol 10, Iss 1, Pp 1-17 (2019)

Abstract Background Allogeneic cardiac-derived progenitor cells (CPC) without immunosuppression could provide an effective ancillary therapy to improve cardiac function in reperfused myocardial infarction. We set out to perform a comprehensive precli

Externí odkaz: https://doaj.org/article/1319baa68af344b39599ee720c32b098

The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells

Autor: Nora Diéguez-Martínez, Héctor Pérez-Montoyo, Guillermo Velasco, Ana Oaknin, Josefina Casas, Tatiana Erazo, Carles Domenech, Pau Muñoz-Guardiola, Cristina Muñoz-Pinedo, Sonia Solé, Guillermo Yoldi, Margarita Romeo, Teresa Moran, Miguel F. Segura, Marc Yeste-Velasco, Gemma Fabriàs, Joaquim Bosch-Barrera, José Luis Abad, Elisabet Megías-Roda, Sergio Espinosa-Gil, Jose M. Lizcano, Jose Alfon

Publikováno v: Autophagy
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
Digital.CSIC. Repositorio Institucional del CSIC

ABTL0812 is a first-in-class small molecule with anti-cancer activity, which is currently in clinical evaluation in a phase 2 trial in patients with advanced endometrial and squamous non-small cell lung carcinoma (NCT03366480). Previously, we showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48b4cf24fd82ac32523d794c3dd89e59
https://doi.org/10.1080/15548627.2020.1761651

Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells

Autor: Antonio Delgado, Mazen Aseeri, José Luis Abad, Núria Bielsa, Mireia Casasampere, Josefina Casas, Gemma Fabriàs

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

Acid (AC), neutral (NC) and alkaline ceramidase 3 (ACER3) are the most ubiquitous ceramidases and their therapeutic interest as targets in cancer diseases has been well sustained. This supports the importance of discovering potent and specific inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3722c27c44424a4c71ef3b262c941e8
https://pubmed.ncbi.nlm.nih.gov/33677352

A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor

Autor: Daniel Riba, Eduardo Izquierdo, Mireia Casasampere, Gemma Fabriàs, Antonio Delgado, Josefina Casas, José Luis Abad, Juan Jesús López-González, Pilar Gema Rodríguez Ortega, Guillem X. Pons, Manuel Montejo

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

The synthesis of a series of vinylated analogues of sphingosine-1-phosphate together with their unambiguous configurational assignment by VCD methods is reported. Among them, compound RBM10-8 can irreversibly inhibit human sphingosine-1-phosphate lya

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36440eea6ba4da213345455ef8e2d2b1
http://hdl.handle.net/10261/212234