Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

Autor: David R. Lisgarten, Rex A. Palmer, Carina M. C. Lobley, Claire E. Naylor, Babur Z. Chowdhry, Zakieh I. Al-Kurdi, Adnan A. Badwan, Brendan J. Howlin, Nicholas C. J. Gibbons, José W. Saldanha, John N. Lisgarten, Ajit K. Basak

Publikováno v: Chemistry Central Journal, Vol 11, Iss 1, Pp 1-26 (2017)

Abstract The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, synchrotron X-ray data collected

Externí odkaz: https://doaj.org/article/2546e37de46f402693f6c4df8de106fa

A complete, multi-level conformational clustering of antibody complementarity-determining regions

Autor: Dimitris Nikoloudis, Jim E. Pitts, José W. Saldanha

Publikováno v: PeerJ, Vol 2, p e456 (2014)

Classification of antibody complementarity-determining region (CDR) conformations is an important step that drives antibody modelling and engineering, prediction from sequence, directed mutagenesis and induced-fit studies, and allows inferences on se

Externí odkaz: https://doaj.org/article/18666df16eb94515922f30be1fed874f

Cmr is a redox-responsive regulator of DosR that contributes to M. tuberculosis virulence

Autor: Stephen Coade, Alix Blockley, Debbie M. Hunt, Nor Azian Hafneh, Roger S. Buxton, Kathryn E.A. Lougheed, Jason C. Crack, Galina V. Mukamolova, Matthew D. Rolfe, Vadim Makarov, Yvonne Braun, Angela Rodgers, José W. Saldanha, Irene Nobeli, Jeffrey Green, Christina Kahramanoglou, Laura J. Smith, Sarah Glenn, Kristine B. Arnvig, Nick E. Le Brun, Aleksandra Bochkareva

Publikováno v: Nucleic Acids Research

RCUK funded OA Mycobacterium tuberculosis (MTb) is the causative agent of pulmonary tuberculosis (TB). MTb colonizes the human lung, often entering a non-replicating state before progressing to life-threatening active infections. Transcriptional repr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04cf636b3ee3e21f529bf4b0707c97be
https://doi.org/10.1093/nar/gkx406

Ultra-high resolution X-ray structures of two forms of human recombinant insulin at 100 K

Autor: Nicholas C. J. Gibbons, Ajit K. Basak, Claire E. Naylor, Adnan A. Badwan, J. N. Lisgarten, José W. Saldanha, Brendan J. Howlin, David R. Lisgarten, Babur Z. Chowdhry, Carina M. C. Lobley, Zakieh I. Al-Kurdi, Rex A. Palmer

Publikováno v: Chemistry Central Journal, Vol 11, Iss 1, Pp 1-26 (2017)
Chemistry Central Journal

The crystal structure of a commercially available form of human recombinant (HR) insulin, Insugen (I), used in the treatment of diabetes has been determined to 0.92 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16,00

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc6f9dac76f4024299badc4ffbf1c14
https://eprints.mdx.ac.uk/22915/1/s13065-017-0296-y.pdf

Partial loss of function of the GHRH Receptor leads to mild Growth Hormone Deficiency

Autor: Kyriaki S. Alatzoglou, Mehul T. Dattani, Mark J. McCabe, Peter C. Hindmarsh, Paul Le Tissier, Louise C. Gregory, Nicola Romanò, José W. Saldanha

Publikováno v: Gregory, L C, Alatzoglou, K S, McCabe, M J, Hindmarsh, P C, Saldanha, J W, Romano, N, Le Tissier, P & Dattani, M T 2016, ' Partial loss of function of the GHRH Receptor leads to mild Growth Hormone Deficiency ', Journal of Clinical Endocrinology & Metabolism, pp. jc20162254 . https://doi.org/10.1210/jc.2016-2254

Objective: Recessive mutations in GHRHR are associated with severe isolated growth hormone deficiency (IGHD), with a final height in untreated patients of 130 cm ± 10 cm (−7.2 ± 1.6 SDS; males) and 114 ± 0.7 cm (−8.3 ± 0.1 SDS; females). Desi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aa8be4f8bdba2bfab6ac217d34b4f35
https://hdl.handle.net/20.500.11820/126d1a33-391e-4e7e-b9cf-6a0dd1d2cbd0