Zobrazeno 1 - 8
of 8
pro vyhledávání: '"José Teófilo Moreira Filho"'
Autor:
Kamilla Rodrigues Rogerio, Leonardo J M Carvalho, Luiza Helena Pinto Domingues, Bruno Junior Neves, José Teófilo Moreira Filho, Rosane Nora Castro, Cesare Bianco Júnior, Claudio Tadeu Daniel-Ribeiro, Carolina Horta Andrade, Cedric Stephan Graebin
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 113, Iss 8 (2018)
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search fo
Externí odkaz:
https://doaj.org/article/5f961a9c94384129912dea3adadd8440
Autor:
Lauro Ribeiro de Souza Neto, Bogar Omar Montoya, José Brandão-Neto, Anil Verma, Sebastian Bowyer, José Teófilo Moreira-Filho, Rafael Ferreira Dantas, Bruno Junior Neves, Carolina Horta Andrade, Frank von Delft, Raymond J. Owens, Nicholas Furnham, Floriano Paes Silva-Jr
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract Schistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but despite that it is ineffective a
Externí odkaz:
https://doaj.org/article/8d7973db04a74ff99b9e972e1795a3fc
Autor:
Ricardo Scheufen Tieghi, José Teófilo Moreira-Filho, Holli-Joi Martin, James Wellnitz, Miguel Canamary Otoch, Marielle Rath, Alexander Tropsha, Eugene N. Muratov, Nicole Kleinstreuer
Publikováno v:
Toxics, Vol 12, Iss 11, p 803 (2024)
Skin sensitization is a significant concern for chemical safety assessments. Traditional animal assays often fail to predict human responses accurately, and ethical constraints limit the collection of human data, necessitating a need for reliable in
Externí odkaz:
https://doaj.org/article/20b0abe052704ae18ced286a45beb8c5
Autor:
José Teófilo Moreira-Filho, Meryck Felipe Brito da Silva, Joyce Villa Verde Bastos Borba, Arlindo Rodrigues Galvão Filho, Eugene N Muratov, Carolina Horta Andrade, Rodolpho de Campos Braga, Bruno Junior Neves
Publikováno v:
Artificial Intelligence in the Life Sciences, Vol 3, Iss , Pp 100055- (2023)
Designing magic shotgun compounds, i.e., compounds hitting multiple targets using artificial intelligence (AI) systems based on machine learning (ML) and deep learning (DL) approaches, has a huge potential to revolutionize drug discovery. Such intell
Externí odkaz:
https://doaj.org/article/70c9ef486f1b47bd90835dd90c8bf1c0
Autor:
Letícia Tiburcio Ferreira, Joyce V. B. Borba, José Teófilo Moreira-Filho, Aline Rimoldi, Carolina Horta Andrade, Fabio Trindade Maranhão Costa
Publikováno v:
Biomolecules, Vol 11, Iss 3, p 459 (2021)
With about 400,000 annual deaths worldwide, malaria remains a public health burden in tropical and subtropical areas, especially in low-income countries. Selection of drug-resistant Plasmodium strains has driven the need to explore novel antimalarial
Externí odkaz:
https://doaj.org/article/4057052bc2ef42f2a386fe09372fb0c6
Autor:
Lauro Ribeiro de Souza Neto, José Teófilo Moreira-Filho, Bruno Junior Neves, Rocío Lucía Beatriz Riveros Maidana, Ana Carolina Ramos Guimarães, Nicholas Furnham, Carolina Horta Andrade, Floriano Paes Silva
Publikováno v:
Frontiers in Chemistry
Frontiers in Chemistry, Vol 8 (2020)
Frontiers in Chemistry, Vol 8 (2020)
Fragment-based drug (or lead) discovery (FBDD or FBLD) has developed in the last two decades to become a successful key technology in the pharmaceutical industry for early stage drug discovery and development. The FBDD strategy consists of screening
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::063fbc5f2c8bdb22bcd909763b7f0a21
Autor:
Bruno J. Neves, Rodolpho C. Braga, Cleber C. Melo-Filho, José Teófilo Moreira-Filho, Eugene N. Muratov, Carolina Horta Andrade
Publikováno v:
Frontiers in Pharmacology
Frontiers in Pharmacology, Vol 9 (2018)
Frontiers in Pharmacology, Vol 9 (2018)
Virtual screening (VS) has emerged in drug discovery as a powerful computational approach to screen large libraries of small molecules for new hits with desired properties that can then be tested experimentally. Similar to other computational approac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85b4bbba6794c1ff07c2086f3ef1fe9d
https://pubmed.ncbi.nlm.nih.gov/30524275
https://pubmed.ncbi.nlm.nih.gov/30524275
Autor:
Cesare Bianco Júnior, José Teófilo Moreira Filho, Cláudio Tadeu Daniel-Ribeiro, Cedric Stephan Graebin, Luiza Helena Pinto Domingues, Kamilla R. Rogério, Carolina Horta Andrade, Leonardo J M Carvalho, Bruno J. Neves, Rosane Nora Castro
Publikováno v:
Memórias do Instituto Oswaldo Cruz, Volume: 113, Issue: 8, Article number: e170452, Published: 18 JUN 2018
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 8 (2018)
Memórias do Instituto Oswaldo Cruz., Vol 113, Iss 8 (2018)
BACKGROUND Malaria is responsible for 429,000 deaths per year worldwide, and more than 200 million cases were reported in 2015. Increasing parasite resistance has imposed restrictions to the currently available antimalarial drugs. Thus, the search fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df810219ef66f8045e9a5ab189f0658
https://doi.org/10.1590/0074-02760170452
https://doi.org/10.1590/0074-02760170452