Zobrazeno 1 - 10
of 140
pro vyhledávání: '"José Sereno"'
Autor:
Sofia Santos, Beatriz Martins, José Sereno, João Martins, Miguel Castelo-Branco, Joana Gonçalves
Publikováno v:
Biology of Sex Differences, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Background Neurofibromatosis type 1 (NF1) is an inherited neurocutaneous disorder associated with neurodevelopmental disorders including autism spectrum disorder (ASD). This condition has been associated with an increase of gamma-aminobutyri
Externí odkaz:
https://doaj.org/article/88983b5010cb4e75bde6fecb8a51f3e2
Autor:
Inês C. F. Fonseca, Mariana Lapo Pais, Fábio M. S. Rodrigues, José Sereno, Miguel Castelo-Branco, Cláudia Cavadas, Mariette M. Pereira, Antero J. Abrunhosa
Publikováno v:
Pharmaceuticals, Vol 17, Iss 4, p 474 (2024)
Neuropeptide Y (NPY) is one of the most abundant peptides in the central nervous system of mammals and is involved in several physiological processes through NPY Y1, Y2, Y4 and Y5 receptors. Of those, the Y2 receptor has particular relevance for its
Externí odkaz:
https://doaj.org/article/9a7cc3037cdf4417b0c11ae063dde911
Autor:
Catarina Oliveira Miranda, Rui Jorge Nobre, Vitor Hugo Paiva, João Valente Duarte, João Castelhano, Lorena Itatí Petrella, José Sereno, Magda Santana, Sónia Afonso, Cristina Januário, Miguel Castelo-Branco, Luís Pereira de Almeida
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-15 (2022)
Abstract Machado-Joseph disease (MJD) or Spinocerebellar ataxia type 3 (SCA3) is the most common form of dominant SCA worldwide. Magnetic Resonance Imaging (MRI) and Proton Magnetic Resonance Spectroscopy (1H-MRS) provide promising non-invasive diagn
Externí odkaz:
https://doaj.org/article/53fa6d99d59142e2a02374537d02c2c1
Autor:
Carla Lopes, I. Luísa Ferreira, Carina Maranga, Margarida Beatriz, Sandra I. Mota, José Sereno, João Castelhano, Antero Abrunhosa, Francisco Oliveira, Maura De Rosa, Michael Hayden, Mário N. Laço, Cristina Januário, Miguel Castelo Branco, A. Cristina Rego
Publikováno v:
Redox Biology, Vol 56, Iss , Pp 102424- (2022)
Deficits in mitochondrial function and redox deregulation have been attributed to Huntington's disease (HD), a genetic neurodegenerative disorder largely affecting the striatum. However, whether these changes occur in early stages of the disease and
Externí odkaz:
https://doaj.org/article/41a596c6e228444184c1c9a70b5c8a8a
Autor:
Diana Duarte Lobo, Rui Jorge Nobre, Catarina Oliveira Miranda, Dina Pereira, João Castelhano, José Sereno, Arnulf Koeppen, Miguel Castelo-Branco, Luís Pereira de Almeida
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-19 (2020)
Abstract Blood-brain barrier (BBB) disruption is a common feature in neurodegenerative diseases. However, BBB integrity has not been assessed in spinocerebellar ataxias (SCAs) such as Machado-Joseph disease/SCA type 3 (MJD/SCA3), a genetic disorder,
Externí odkaz:
https://doaj.org/article/6ef536bc9a6442f3aa1022346306db58
Autor:
Samuel Chiquita, Elisa J. Campos, João Castelhano, Mário Ribeiro, José Sereno, Paula I. Moreira, Miguel Castelo-Branco, António Francisco Ambrósio
Publikováno v:
Alzheimer’s Research & Therapy, Vol 11, Iss 1, Pp 1-16 (2019)
Abstract Background It has been claimed that the retina can be used as a window to study brain disorders. However, concerning Alzheimer’s disease (AD), it still remains controversial whether changes occurring in the brain and retina are associated.
Externí odkaz:
https://doaj.org/article/002ed5acb62a4f51988d24f977fa9335
Autor:
Jonatan Dewulf, Ivanna Hrynchak, Sarah Geudens, Isabel Pintelon, Christel Vangestel, José Sereno, Peter A. van Dam, Antero J. Abrunhosa, Filipe Elvas, Tim Van den Wyngaert
Publikováno v:
Pharmaceutics, Vol 14, Iss 5, p 939 (2022)
Purpose: RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific a
Externí odkaz:
https://doaj.org/article/dd3ae99d194e49d6bb5a1b33de65bfcc
Autor:
Helena Ferreira, Ana Catarina Sousa, José Sereno, João Martins, Miguel Castelo-Branco, Joana Gonçalves
Publikováno v:
Metabolites, Vol 12, Iss 1, p 71 (2022)
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social interaction, impaired communication, and repetitive behaviors. ASD presents a 3:1 ratio of diagnosed boys and girls, raising the question regarding s
Externí odkaz:
https://doaj.org/article/69f9a6e2e83247cfa6bbe519f71a5171
Autor:
Joana Gonçalves, Inês R. Violante, José Sereno, Ricardo A. Leitão, Ying Cai, Antero Abrunhosa, Ana Paula Silva, Alcino J. Silva, Miguel Castelo-Branco
Publikováno v:
Molecular Autism, Vol 8, Iss 1, Pp 1-8 (2017)
Abstract Background Excitation/inhibition (E/I) imbalance remains a widely discussed hypothesis in autism spectrum disorders (ASD). The presence of such an imbalance may potentially define a therapeutic target for the treatment of cognitive disabilit
Externí odkaz:
https://doaj.org/article/3383b8df02da4f888b419fbaa5beed83
Autor:
Tiago Rodrigues, Paulo Matafome, José Sereno, José Almeida, João Castelhano, Luís Gamas, Christian Neves, Sónia Gonçalves, Catarina Carvalho, Amina Arslanagic, Elinor Wilcken, Rita Fonseca, Ilda Simões, Silvia Vilares Conde, Miguel Castelo-Branco, Raquel Seiça
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Microvascular dysfunction has been suggested to trigger adipose tissue dysfunction in obesity. This study investigates the hypothesis that glycation impairs microvascular architecture and expandability with an impact on insulin signalling. A
Externí odkaz:
https://doaj.org/article/effcd88d66a84a7babf0d9edf75eb38e