Gamma Delta T-Cell Based Cancer Immunotherapy: Past-Present-Future

Autor: José Saura-Esteller, Milon de Jong, Lisa A. King, Erik Ensing, Benjamin Winograd, Tanja D. de Gruijl, Paul W. H. I. Parren, Hans J. van der Vliet

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

γδ T-cells directly recognize and kill transformed cells independently of HLA-antigen presentation, which makes them a highly promising effector cell compartment for cancer immunotherapy. Novel γδ T-cell-based immunotherapies, primarily focusing

Externí odkaz: https://doaj.org/article/57a7fb13f9c9431cbab1118c84862f44

The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells through the upregulation of NOXA and synergizes with ibrutinib, 5-aminoimidazole-4-carboxamide riboside or venetoclax

Autor: Ana M. Cosialls, Helena Pomares, Daniel Iglesias-Serret, José Saura-Esteller, Sonia Núñez-Vázquez, Diana M. González-Gironès, Esmeralda de la Banda, Sara Preciado, Fernando Albericio, Rodolfo Lavilla, Gabriel Pons, Eva M. González-Barca, Joan Gil

Publikováno v: Haematologica, Vol 102, Iss 9 (2017)

Fluorizoline is a new synthetic molecule that induces apoptosis by selectively targeting prohibitins. In the study herein, the pro-apoptotic effect of fluorizoline was assessed in 34 primary samples from patients with chronic lymphocytic leukemia. Fl

Externí odkaz: https://doaj.org/article/c95cb8c5b86641bb807f8687979d82da

Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines

Autor: Pablo M. Garcia-Roves, Gauri Bhosale, Lorena Mendive-Tapia, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, Michael R. Duchen, Pau Gama-Perez, Gabriel Pons, Rodolfo Lavilla, Daniel Iglesias-Serret, Ana M. Cosialls, Joan Gil, José Saura-Esteller

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 6117, p 6117 (2021)

The prohibitin (PHB)-binding compound fluorizoline as well as PHB-downregulation activate the integrated stress response (ISR) in HEK293T and U2OS human cell lines. This activation is denoted by phosphorylation of eIF2α and increases in ATF4, ATF3,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf55405285e675df6a64d29f68cee6b5
http://hdl.handle.net/2445/178630

Fluorizoline-induced apoptosis requires prohibitins in nematodes and human cells

Autor: José, Saura-Esteller, Ismael, Sánchez-Vera, Sonia, Núñez-Vázquez, Judith, Jabalquinto-Carrasco, Ana M, Cosialls, Lorena, Mendive-Tapia, Dmytro, Kukhtar, Manuel D, Martínez-Bueno, Rodolfo, Lavilla, Julián, Cerón, Marta, Artal-Sanz, Gabriel, Pons, Daniel, Iglesias-Serret, Joan, Gil

Publikováno v: Apoptosis : an international journal on programmed cell death. 26(1-2)

We previously showed that fluorizoline, a fluorinated thiazoline compound, binds to both subunits of the mitochondrial prohibitin (PHB) complex, PHB1 and PHB2, being the expression of these proteins required for fluorizoline-induced apoptosis in mous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::afcb1501ef5d66833c8f7afa43a9425e
https://pubmed.ncbi.nlm.nih.gov/33387147

NOXA upregulation by the prohibitin-binding compound fluorizoline is transcriptionally regulated by integrated stress response-induced ATF3 and ATF4

Autor: Joan Gil, Gabriel Pons, Ana M. Cosialls, Ismael Sánchez-Vera, Sonia Núñez-Vázquez, José Saura-Esteller, Rodolfo Lavilla, Daniel Iglesias-Serret, Fernando Albericio, Anaïs F.M. Noisier

Publikováno v: The FEBS journalReferences. 288(4)

Fluorizoline is a new synthetic molecule that induces p53-independent apoptosis, in several tumor cell lines and in primary leukemia cells, by selectively targeting prohibitins (PHBs). In this study, we describe how fluorizoline induces BCL-2 homolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c488cdf3fbc8871023e9b7988f27aaea
https://pubmed.ncbi.nlm.nih.gov/32648994