Enhancing Cancer Diagnosis with Real-Time Feedback: Tumor Metabolism through Hyperpolarized 1-13C Pyruvate MRSI

Autor: Gaurav Sharma, José S. Enriquez, Ryan Armijo, Muxin Wang, Pratip Bhattacharya, Shivanand Pudakalakatti

Publikováno v: Metabolites, Vol 13, Iss 5, p 606 (2023)

This review article discusses the potential of hyperpolarized (HP) 13C magnetic resonance spectroscopic imaging (MRSI) as a noninvasive technique for identifying altered metabolism in various cancer types. Hyperpolarization significantly improves the

Externí odkaz: https://doaj.org/article/530607acd2d840279394fed6ae3c4022

Metabolic Imaging Using Hyperpolarization for Assessment of Premalignancy

Autor: Shivanand Pudakalakatti, Priyank Raj, Travis C. Salzillo, José S. Enriquez, Dontrey Bourgeois, Prasanta Dutta, Mark Titus, Shayan Shams, Priya Bhosale, Michael Kim, Florencia McAllister, Pratip K. Bhattacharya

Publikováno v: Methods Mol Biol
Methods in Molecular Biology ISBN: 9781071620137

There is an unmet need for noninvasive surrogate markers that can help identify premalignant lesions across different tumor types. Here we describe the methodology and technical details of protocols employed for in vivo (13)C pyruvate metabolic imagi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b24732c986ae6dedeb79307eead4b454
https://europepmc.org/articles/PMC9352438/

Hyperpolarized MRI with silicon micro and nanoparticles: Principles and applications

Autor: Pratip K. Bhattacharya, Shivanand Pudakalakatti, José S. Enriquez, Daniel D. Carson, Dontrey Bourgeois, Niki M. Zacharias, Saleh Ramezani, Jennifer S. Davis, Mary C. Farach-Carson, Caitlin McCowan, Pamela E. Constantinou, Daniel A. Harrington

Publikováno v: Wiley Interdiscip Rev Nanomed Nanobiotechnol

Silicon-based micro and nanoparticles are ideally suited for use as biomedical imaging agents because of their biocompatibility, biodegradability, and simple surface chemistry that facilitates drug loading and targeting. A method to hyperpolarize sil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba0646bfd3c3b1efaff9023d73521a9
https://doi.org/10.1002/wnan.1722

Identifying the Metabolic Signatures of PPARD-Overexpressing Gastric Tumors

Autor: Shivanand Pudakalakatti, Mark Titus, José S. Enriquez, Sumankalai Ramachandran, Niki M. Zacharias, Imad Shureiqi, Yi Liu, James C. Yao, Xiangsheng Zuo, Pratip K. Bhattacharya

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 1645, p 1645 (2022)
International Journal of Molecular Sciences; Volume 23; Issue 3; Pages: 1645

Peroxisome proliferator-activated receptor delta (PPARD) is a nuclear receptor known to play an essential role in regulation of cell metabolism, cell proliferation, inflammation, and tumorigenesis in normal and cancer cells. Recently, we found that a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8bde0711a069b96df7023e4b219136c
https://doi.org/10.3390/ijms23031645

Hypoxia-Responsive 19F MRI Probes with Improved Redox Properties and Biocompatibility

Autor: José S. Enriquez, Da Xie, Vikraant Kohli, Emily L. Que, Jeffrey J. Luci, Seyong Kim, Arnab Banerjee, Meng Yu

Publikováno v: Inorganic Chemistry. 56:6429-6437

19F magnetic resonance imaging (MRI), an emerging modality in biomedical imaging, has shown promise for in vitro and in vivo preclinical studies. Here we present a series of fluorinated Cu(II)ATSM derivatives for potential use as 19F magnetic resonan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59def7260882d6591e421b623ecd370a
https://doi.org/10.1021/acs.inorgchem.7b00500