A genome-wide study of DNA methylation in white blood cells and asthma in Latino children and youth

Autor: Yale Jiang, Erick Forno, Yueh-Ying Han, Zhongli Xu, Donglei Hu, Nadia Boutaoui, Celeste Eng, Edna Acosta-Pérez, Scott Huntsman, Angel Colón-Semidey, Kevin L. Keys, José R. Rodríguez-Santana, María Alvarez, Maria Pino-Yanes, Glorisa Canino, Wei Chen, Esteban G. Burchard, Juan C. Celedón

Publikováno v: Epigenetics, Vol 16, Iss 5, Pp 577-585 (2021)

Latinos are heavily affected with childhood asthma. Little is known about epigenetic mechanisms of asthma in Latino youth. We conducted a meta-analysis of two epigenome-wide association studies (EWAS) of asthma, using DNA from white blood cells (WBCs

Externí odkaz: https://doaj.org/article/cf590e9b7397474d90b1a02e04c96e6c

Gene expression in African Americans, Puerto Ricans and Mexican Americans reveals ancestry-specific patterns of genetic architecture

Autor: Linda Kachuri, Angel C. Y. Mak, Donglei Hu, Celeste Eng, Scott Huntsman, Jennifer R. Elhawary, Namrata Gupta, Stacey Gabriel, Shujie Xiao, Kevin L. Keys, Akinyemi Oni-Orisan, José R. Rodríguez-Santana, Michael A. LeNoir, Luisa N. Borrell, Noah A. Zaitlen, L. Keoki Williams, Christopher R. Gignoux, Esteban González Burchard, Elad Ziv

Publikováno v: Nature Genetics.

We explored the role of genetic ancestry in shaping the genetic architecture of whole blood gene expression using whole genome and RNA sequencing data from 2,733 African American and Hispanic/Latino children. We find that heritability of gene express

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d75481c7484dabb2022d2c9eef8a4c
https://doi.org/10.1038/s41588-023-01377-z

Admixture mapping of severe asthma exacerbations in Hispanic/Latino children and youth

Autor: Esther Herrera-Luis, Angel C Y Mak, Javier Perez-Garcia, Elena Martin-Gonzalez, Celeste Eng, Kenneth B Beckman, Scott Huntsman, Donglei Hu, Ruperto González-Pérez, José M Hernández-Pérez, Elena Mederos-Luis, Yang Yie Sio, Paloma Poza-Guedes, Olaia Sardón, Paula Corcuera, Inmaculada Sánchez-Machín, Javier Korta-Murua, Carlos Martínez-Rivera, Joaquim Mullol, Xavier Muñoz, Antonio Valero, Joaquin Sastre, Judith Garcia-Aymerich, Sabrina Llop, Maties Torrent, Maribel Casas, José R Rodríguez-Santana, Jesús Villar, Victoria del Pozo, Fabian Lorenzo-Diaz, L Keoki Williams, Erik Melén, Fook Tim Chew, Luisa N Borrell, Esteban G Burchard, Maria Pino-Yanes

Publikováno v: Thorax
r-IGTP. Repositorio Institucional de Producción Científica del Instituto de Investigación Germans Trias i Pujol
instname
THORAX
r-FISABIO. Repositorio Institucional de Producción Científica

Background: In the USA, genetically admixed populations have the highest asthma prevalence and severe asthma exacerbations rates. This could be explained not only by environmental factors but also by genetic variants that exert ethnic-specific effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8543e28811c1be75567bb4bf72951111
https://pubmed.ncbi.nlm.nih.gov/36180068

Identification of KIF3A as a novel candidate gene for childhood asthma using RNA expression and population allelic frequencies differences.

Autor: Melinda Butsch Kovacic, Jocelyn M Biagini Myers, Ning Wang, Lisa J Martin, Mark Lindsey, Mark B Ericksen, Hua He, Tia L Patterson, Tesfaye M Baye, Dara Torgerson, Lindsey A Roth, Jayanta Gupta, Umasundari Sivaprasad, Aaron M Gibson, Anna M Tsoras, Donglei Hu, Celeste Eng, Rocío Chapela, José R Rodríguez-Santana, William Rodríguez-Cintrón, Pedro C Avila, Kenneth Beckman, Max A Seibold, Chris Gignoux, Salma M Musaad, Weiguo Chen, Esteban González Burchard, Gurjit K Khurana Hershey

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23714 (2011)

Asthma is a chronic inflammatory disease with a strong genetic predisposition. A major challenge for candidate gene association studies in asthma is the selection of biologically relevant genes.Using epithelial RNA expression arrays, HapMap allele fr

Externí odkaz: https://doaj.org/article/5f4cc418e1864f3d8f3a32d8a027af35

Expression of SMARCD1 interacts with age in association with asthma control on inhaled corticosteroid therapy

Autor: Michael J. McGeachie, Joanne E. Sordillo, Amber Dahlin, Alberta L. Wang, Sharon M. Lutz, Kelan G. Tantisira, Ronald Panganiban, Quan Lu, Satria Sajuthi, Cydney Urbanek, Rachel Kelly, Benjamin Saef, Celeste Eng, Sam S. Oh, Alvin T. Kho, Damien C. Croteau-Chonka, Scott T. Weiss, Benjamin A. Raby, Angel C. Y. Mak, Jose R. Rodriguez-Santana, Esteban G. Burchard, Max A. Seibold, Ann Chen Wu

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-8 (2020)

Abstract Background Global gene expression levels are known to be highly dependent upon gross demographic features including age, yet identification of age-related genomic indicators has yet to be comprehensively undertaken in a disease and treatment

Externí odkaz: https://doaj.org/article/fffacd0e6d1c4c46ad483388a089547f