Zobrazeno 1 - 10
of 17
pro vyhledávání: '"José R. Navarro-Betancourt"'
Autor:
Andrey V. Cybulsky, Joan Papillon, Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, I. George Fantus
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Protein misfolding in the endoplasmic reticulum (ER) of podocytes contributes to the pathogenesis of glomerular diseases. Protein misfolding activates the unfolded protein response (UPR), a compensatory signaling network. We address the role
Externí odkaz:
https://doaj.org/article/9013771e3f6a4da1928202208f87bf53
Publikováno v:
Physiological Reports, Vol 12, Iss 1, Pp n/a-n/a (2024)
Abstract SLK controls the cytoskeleton, cell adhesion, and migration. Podocyte‐specific deletion of SLK in mice leads to podocyte injury as mice age and exacerbates injury in experimental focal segment glomerulosclerosis (FSGS; adriamycin nephrosis
Externí odkaz:
https://doaj.org/article/983993ac9f3844aa8d8698faf39009c1
Autor:
Víctor M. Arenas-Luna, Juan J. Montesinos, Víctor A. Cortés-Morales, José R. Navarro-Betancourt, Janneth Peralta-Ildefonso, Bulmaro Cisneros, Salomón Hernández-Gutiérrez
Publikováno v:
Current Issues in Molecular Biology, Vol 45, Iss 1, Pp 268-285 (2022)
Inside tumors, cancer cells display several mechanisms to create an immunosuppressive environment. On the other hand, by migration processes, mesenchymal stromal cells (MSCs) can be recruited by different cancer tumor types from tissues as distant as
Externí odkaz:
https://doaj.org/article/60f265bd1a82457d97b2d701316ad5f1
Autor:
Chen-Fang Chung, Joan Papillon, José R. Navarro-Betancourt, Julie Guillemette, Ameya Bhope, Amin Emad, Andrey V. Cybulsky
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundHuman glomerulonephritis (GN)—membranous nephropathy (MN), focal segmental glomerulosclerosis (FSGS) and IgA nephropathy (IgAN), as well as diabetic nephropathy (DN) are leading causes of chronic kidney disease. In these glomerulopathies,
Externí odkaz:
https://doaj.org/article/0f84a28e78cc495ea2e2ba9ca816efb5
Publikováno v:
Frontiers in Molecular Medicine. 2
Endoplasmic reticulum (ER) function is vital for protein homeostasis (“proteostasis”). Protein misfolding in the ER of podocytes (glomerular visceral epithelial cells) is an important contributor to the pathogenesis of human glomerular diseases.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d20c62fe1a1f06a257c0079951268f8
https://doi.org/10.3389/fmmed.2022.971247
https://doi.org/10.3389/fmmed.2022.971247
Autor:
Joan Papillon, Andrey V. Cybulsky, Boyan Woychyshyn, José R. Navarro-Betancourt, Julie Guillemette
Publikováno v:
American Journal of Physiology-Renal Physiology. 318:F1377-F1390
Ste20-like kinase SLK is critical for embryonic development and may play an important role in wound healing, muscle homeostasis, cell migration, and tumor growth. Mice with podocyte-specific deletion of SLK show albuminuria and damage to podocytes as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4249dc3d55cbb9d2c006fa46e648eb3
https://doi.org/10.1152/ajprenal.00028.2020
https://doi.org/10.1152/ajprenal.00028.2020
Autor:
José R. Navarro-Betancourt, Joan Papillon, Julie Guillemette, Chen-Fang Chung, Takao Iwawaki, Andrey V. Cybulsky
Publikováno v:
Biochimica et biophysica acta. Molecular basis of disease. 1868(6)
Glomerular diseases involving podocyte/glomerular epithelial cell (GEC) injury feature protein misfolding and endoplasmic reticulum (ER) stress. Inositol-requiring enzyme 1α (IRE1α) mediates chaperone production and autophagy during ER stress. We e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d5eaf4f2bd86a05265744b191ffb90d
https://pubmed.ncbi.nlm.nih.gov/35304860
https://pubmed.ncbi.nlm.nih.gov/35304860
Autor:
José R. Navarro-Betancourt, Andrey V. Cybulsky, Hanan Elimam, Julie Guillemette, Joan Papillon
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
Genetic ablation of calcium-independent phospholipase A2γ (iPLA2γ) in mice results in marked damage of mitochondria and enhanced autophagy in glomerular visceral epithelial cells (GECs) or podocytes. The present study addresses the role of iPLA2γ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac0073fa3fdcd8dcdeef34ee3b2a9ace
http://link.springer.com/article/10.1038/s41598-019-52834-x
http://link.springer.com/article/10.1038/s41598-019-52834-x
Autor:
Julie Guillemette, José R. Navarro-Betancourt, Chen-Fang Chung, Takao Iwawaki, Joan Papillon, Andrey V. Cybulsky
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 6, Iss 1, Pp 1-15 (2020)
Cell Death Discovery, Vol 6, Iss 1, Pp 1-15 (2020)
Glomerular epithelial cell (GEC)/podocyte proteostasis is dysregulated in glomerular diseases. The unfolded protein response (UPR) is an adaptive pathway in the endoplasmic reticulum (ER) that upregulates proteostasis resources. This study characteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9b149e37e3e57c9df58698ac381cd4
http://europepmc.org/articles/PMC7677398
http://europepmc.org/articles/PMC7677398
Autor:
Azucena Martínez-Basila, Mariela Bernabe-García, Alejandra Salas-Fernández, Mónica I. Piña-Aguero, Jorge Maldonado-Hernández, José R. Navarro-Betancourt
Publikováno v:
Journal of Clinical Research in Pediatric Endocrinology
Objective: To evaluate the use of the 13C-glucose breath test (13C-GBT) for insulin resistance (IR) detection in adolescents through comparison with fasting and post-glucose stimulus surrogates. Methods: One hundred thirty-three adolescents aged betw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd40793481bd04aa9b36c47871685b3b
https://doi.org/10.4274/jcrpe.3260
https://doi.org/10.4274/jcrpe.3260