Zobrazeno 1 - 10 of 70 pro vyhledávání: '"José R. López López"'
1
Akademický článek
A sex-dependent role of Kv1.3 channels from macrophages in metabolic syndrome
Autor: Diego A. Peraza, Lucía Benito-Salamanca, Sara Moreno-Estar, Esperanza Alonso, José R. López-López, M. Teresa Pérez-Garcia, Pilar Cidad
Publikováno v: Frontiers in Physiology, Vol 15 (2024)
IntroductionCoronary artery disease (CAD) is the foremost single cause of mortality and disability globally. Patients with type 2 diabetes (T2DM) have a higher incidence of CAD, and poorer prognosis. The low-grade inflammation associated to T2DM cont
Externí odkaz: https://doaj.org/article/ad3ca193969c450d8a4bdd0cc6067603
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2
Akademický článek
Development of a novel in vitro model to study the modulatory role of the respiratory complex I in macrophage effector functions.
Autor: Pablo Serrano-Lorenzo, Dino Gobelli, Rocío Garrido-Moraga, María J Esteban-Amo, José R López-López, Antonio Orduña, Miguel A de la Fuente, Miguel A Martín, María Simarro
Publikováno v: PLoS ONE, Vol 18, Iss 9, p e0291442 (2023)
Increasing evidence demonstrate that the electron transfer chain plays a critical role in controlling the effector functions of macrophages. In this work, we have generated a Ndufs4-/- murine macrophage cell lines. The Ndufs4 gene, which encodes a su
Externí odkaz: https://doaj.org/article/aeb7cfd379d74a5292fbea2e3d86310c
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3
Akademický článek
miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers
Autor: Marycarmen Arevalo-Martinez, Pilar Cidad, Sara Moreno-Estar, Mirella Fernández, Sebastian Albinsson, Irene Cózar-Castellano, José R. López-López, M. Teresa Pérez-Garcia
Publikováno v: Molecular Metabolism, Vol 53, Iss , Pp 101306- (2021)
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impact on restenosis, with patien
Externí odkaz: https://doaj.org/article/e00a9e75cdf44eabb6c98499dacf5b54
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4
Akademický článek
Phenotypic Modulation of Cultured Primary Human Aortic Vascular Smooth Muscle Cells by Uremic Serum
Autor: Violeta Cazaña-Pérez, Pilar Cidad, Javier Donate-Correa, Ernesto Martín-Núñez, José R. López-López, M. Teresa Pérez-García, Teresa Giraldez, Juan F. Navarro-González, Diego Alvarez de la Rosa
Publikováno v: Frontiers in Physiology, Vol 9 (2018)
Patients with chronic kidney disease (CKD) have a markedly increased incidence of cardiovascular disease (CVD). The high concentration of circulating uremic toxins and alterations in mineral metabolism and hormone levels produce vascular wall remodel
Externí odkaz: https://doaj.org/article/aef3796622fb4390b85161f40a074f7c
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5
Elastin-like recombinamer-based devices releasing Kv1.3 blockers for the prevention of intimal hyperplasia: An in vitro and in vivo study
Autor: F. Javier Arias, Mercedes Santos, M. Teresa Pérez-García, Pilar Cidad, Sofía Serrano, Marycarmen Arévalo-Martínez, Sara Moreno-Estar, José R. López-López
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Coronary artery disease (CAD) is the most common cardiovascular disorder. Vascular surgery strategies for coronary revascularization (either percutaneous or open) show a high rate of failure because of restenosis of the vessel, due to phenotypic swit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efb3baae241743045d2a7d1330f6fa85
https://doi.org/10.1016/j.actbio.2020.07.053
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6
Kv1.3 blockade inhibits proliferation of vascular smooth muscle cells in vitro and intimal hyperplasia in vivo
Autor: José R. López-López, Montserrat Rigol, Núria Solanes, Felipe Fernández-Vázquez, Claudia Pérez-Martínez, Joaquim Bobi, Manel Sabaté, Mercè Roqué, Victor Ramos-Pérez, Mª Teresa Pérez-García, Alberto Ponce, Xavier Freixa, Manel Garabito, Salvador Borrós, Armando Pérez de Prado, Pilar Cidad
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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© 2020 Published by Elsevier Inc
The modulation of voltage-gated K+ (Kv) channels, involved in cell proliferation, arises as a potential therapeutic approach for the prevention of intimal hyperplasia present in in-stent restenosis (ISR) and all
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32bb00fc7a81049a598faef178cb8a6e
https://doi.org/10.1016/j.trsl.2020.06.002
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7
miR-126 contributes to the epigenetic signature of diabetic vascular smooth muscle and enhances antirestenosis effects of Kv1.3 blockers
Autor: José R. López-López, Pilar Cidad, Mirella Fernández, Sebastian Albinsson, Sara Moreno-Estar, M. Teresa Pérez-García, Irene Cózar-Castellano, Marycarmen Arévalo-Martínez
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
UVaDOC. Repositorio Documental de la Universidad de Valladolid
Molecular Metabolism, Vol 53, Iss, Pp 101306-(2021)
Molecular Metabolism
Producción Científica
Objectives: Restenosis after vessel angioplasty due to dedifferentiation of the vascular smooth muscle cells (VSMCs) limits the success of surgical treatment of vascular occlusions. Type 2 diabetes (T2DM) has a major impa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cbcc347fd83fc9d342ee5c3f4b295be
http://hdl.handle.net/10261/260813
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8
Akademický článek
Tungstate-targeting of BKαβ1 channels tunes ERK phosphorylation and cell proliferation in human vascular smooth muscle.
Autor: Ana Isabel Fernández-Mariño, Pilar Cidad, Delia Zafra, Laura Nocito, Jorge Domínguez, Aida Oliván-Viguera, Ralf Köhler, José R López-López, María Teresa Pérez-García, Miguel Ángel Valverde, Joan J Guinovart, José M Fernández-Fernández
Publikováno v: PLoS ONE, Vol 10, Iss 2, p e0118148 (2015)
Despite the substantial knowledge on the antidiabetic, antiobesity and antihypertensive actions of tungstate, information on its primary target/s is scarce. Tungstate activates both the ERK1/2 pathway and the vascular voltage- and Ca2+-dependent larg
Externí odkaz: https://doaj.org/article/25b697aef0f54fd5af54d19183c72a86
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10
Activation of the cation channel TRPM3 in perivascular nerves induces vasodilation of resistance arteries
Autor: M. T. Pérez-García, Lucía Alonso-Carbajo, Justyna B. Startek, Karel Talavera, José R. López-López, Yeranddy A. Alpizar
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
The Transient Receptor Potential Melastatin 3 (TRPM3) is a Ca2+-permeable non-selective cation channel activated by the neurosteroid pregnenolone sulfate (PS). This compound was previously shown to contract mouse aorta by activating TRPM3 in vascular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebcce50c9100658cc48f07dc22e4d36
https://doi.org/10.1016/j.yjmcc.2019.03.003
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