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Akademický článek

Status Epilepticus with Fever in a Toddler with Pyogenic Meningitis Due to Complicated Acute Sphenoid Sinusitis

Autor: Jay Pershad, MD, Lexi Crawford, MD, Diego Preciado, MD, Dana Harrar, MD, Jose Molto, MD, Craig Shapiro, MD

Publikováno v: Journal of Pediatrics: Clinical Practice, Vol 14, Iss , Pp 200123- (2024)

We present a toddler with acute sphenoid sinusitis presenting as status epilepticus with fever, intracranial abscess and meningitis. Cerebrospinal fluid analysis suggested bacterial meningitis, but polymerase chain reaction test was positive for huma

Externí odkaz: https://doaj.org/article/6f4a1f16ab7f4048b358b0cbc285548c

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Akademický článek

Immunogenicity, reactogenicity, and safety of a second booster with BNT162b2 or full-dose mRNA-1273: A randomized VACCELERATE trial in adults aged ≥75 years (EU-COVAT-1-AGED Part B)

Publikováno v: International Journal of Infectious Diseases, Vol 146, Iss , Pp 107161- (2024)

Objectives: To assess the safety and immunogenicity of a fourth vaccination (second booster) in individuals aged ≥75 years. Methods: Participants were randomized to BNT162b2 (Comirnaty, 30 µg) or messenger RNA (mRNA)-1273 (Spikevax, 100 µg). The

Externí odkaz: https://doaj.org/article/f8eb2936f1bc47e680925b02612648b5

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Akademický článek

Outcomes of Drug Interactions Between Antiretrovirals and Co-Medications, Including Over-the-Counter Drugs: A Real-World Study

Autor: Juan Ambrosioni, Natalia Anahí Díaz, Catia Marzolini, Gordana Dragovic, Arkaitz Imaz, Andrea Calcagno, Sonia Luque, Adrian Curran, Jesus Troya, Montse Tuset, Saye Khoo, David Burger, Claudia P. Cortés, Nadia Naous, Jose Molto

Publikováno v: Infectious Diseases and Therapy, Vol 13, Iss 3, Pp 609-617 (2024)

Abstract Introduction The objective was to characterize real-world outcomes of drug–drug interactions (DDIs) between antiretrovirals (ARVs) and other drugs, including over-the-counter medications (OTC), and treatment outcomes in clinical practice.

Externí odkaz: https://doaj.org/article/9cb1d0d928f24001acf11ec6ab390c06

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Akademický článek

Plasma proteomic profiling identifies CD33 as a marker of HIV control in natural infection and after therapeutic vaccinationResearch in context

Autor: Clara Duran-Castells, Anna Prats, Bruna Oriol-Tordera, Anuska Llano, Cristina Galvez, Javier Martinez-Picado, Ester Ballana, Edurne Garcia-Vidal, Bonaventura Clotet, Jose A. Muñoz-Moreno, Thomas Hanke, José Moltó, Beatriz Mothe, Christian Brander, Marta Ruiz-Riol

Publikováno v: EBioMedicine, Vol 95, Iss , Pp 104732- (2023)

Summary: Background: Biomarkers predicting the outcome of HIV-1 virus control in natural infection and after therapeutic interventions in HIV-1 cure trials remain poorly defined. The BCN02 trial (NCT02616874), combined a T-cell vaccine with romidepsi

Externí odkaz: https://doaj.org/article/3b80065fccfc4b748f1b0fc22a58d62a

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Akademický článek

Gut microbiome signatures linked to HIV-1 reservoir size and viremia control

Publikováno v: Microbiome, Vol 10, Iss 1, Pp 1-15 (2022)

Abstract Background The potential role of the gut microbiome as a predictor of immune-mediated HIV-1 control in the absence of antiretroviral therapy (ART) is still unknown. In the BCN02 clinical trial, which combined the MVA.HIVconsv immunogen with

Externí odkaz: https://doaj.org/article/f4eb4630f5eb4505a01baefcff14f0eb

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Absence of a relation between efavirenz plasma concentrations and toxicity-driven efavirenz discontinuations in the EuroSIDA study

Autor: Matthijs, van Luin, Wendy P, Bannister, Amanda, Mocroft, Peter, Reiss, Giovanni, Di Perri, Gilles, Peytavin, José, Molto, Anders, Karlson, Antonella, Castagna, Marek, Beniowski, Jens D, Lundgren, David M, Burger

Publikováno v: Antiviral therapy. 14(1)

Co1nflicting data exist regarding the effect of efavirenz (EFV) plasma concentrations on central nervous system (CNS) toxicity. We aimed to determine whether patients with high EFV plasma concentrations have an increased likelihood of toxicity-driven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c6039b1c2dec22a654a48f668d0efa45
https://pubmed.ncbi.nlm.nih.gov/19320239

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Akademický článek

Epigenetic landscape in the kick-and-kill therapeutic vaccine BCN02 clinical trial is associated with antiretroviral treatment interruption (ATI) outcome

Publikováno v: EBioMedicine, Vol 78, Iss , Pp 103956- (2022)

Summary: Background: The BCN02-trial combined therapeutic vaccination with a viral latency reversing agent (romidepsin, RMD) in HIV-1-infected individuals and included a monitored antiretroviral pause (MAP) as an efficacy read-out identifying individ

Externí odkaz: https://doaj.org/article/9f3d6a37e4e5465486ac479f3e27ef6c

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Akademický článek

Ambrisentan use in a HIV-1 infected patient with end-stage renal disease and pulmonary hypertension: minimal removal by hemodialysis - a case report

Autor: José Ramón Santos, Ana Merino, Walter E. Haefeli, Cristina Miranda, Marisol Prats, Ioana Bancu, Lucía Bailón, José Moltó

Publikováno v: BMC Nephrology, Vol 21, Iss 1, Pp 1-4 (2020)

Abstract Background Ambrisentan is a selective endothelin receptor antagonist used for the treatment of pulmonary arterial hypertension (PAH). Little is known about ambrisentan removal by hemodialysis in patients with end-stage renal disease (ESRD).

Externí odkaz: https://doaj.org/article/a7d2c829d4fd40eea40e824b20cfb7c0

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