Zobrazeno 1 - 10
of 87
pro vyhledávání: '"José Miguel Azevedo"'
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 15, p 8141 (2024)
Cystatin F (CstF) is a protease inhibitor of cysteine cathepsins, including those involved in activating the perforin/granzyme cytotoxic pathways. It is targeted at the endolysosomal pathway but can also be secreted to the extracellular milieu or end
Externí odkaz:
https://doaj.org/article/8312d3a29d8b456883c2837d6c56ac62
Publikováno v:
Biomolecules, Vol 14, Iss 7, p 848 (2024)
Tuberculosis and AIDS remain two of the most relevant human infectious diseases. The pathogens that cause them, Mycobacterium tuberculosis (Mtb) and HIV, individually elicit an immune response that treads the line between beneficial and detrimental t
Externí odkaz:
https://doaj.org/article/a8737089735848548b75be701e76fa54
Publikováno v:
Gazeta Médica, Vol 1, Iss 1 (2023)
A asma é uma doença crónica muito frequente na infância, sendo o montelucaste utilizado no seu tratamento. Este fármaco tem sido associado a alterações neuropsiquiátricas potencialmente letais. O objetivo desta revisão é avaliar a evidênci
Externí odkaz:
https://doaj.org/article/cb99bdefdbd5443e80339527e9c09230
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cathepsins were first described, as endolysosomal proteolytic enzymes in reference to the organelles where they degrade the bulk of endogenous and exogenous substrates in a slightly acidic environment. These substrates include pathogens internalized
Externí odkaz:
https://doaj.org/article/be8c1c915c8144ddac1aadf716b4b5af
Publikováno v:
Microorganisms, Vol 11, Iss 7, p 1861 (2023)
Tuberculosis (TB) treatment relies primarily on 70-year-old drugs, and prophylaxis suffers from the lack of an effective vaccine. Among the 10 million people exhibiting disease symptoms yearly, 450,000 have multidrug or extensively drug-resistant (MD
Externí odkaz:
https://doaj.org/article/2b6bdd2aff4f4531a9716597f03217b6
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 968 (2023)
Mycobacterium tuberculosis (Mtb), the causative agent of human tuberculosis (TB), is one of the most successfully adapted human pathogens. Human-to-human transmission occurs at high rates through aerosols containing bacteria, but the pathogen evolved
Externí odkaz:
https://doaj.org/article/95e5b7fa88264b2393d146c3daf67db4
Autor:
Marta Calado, David Pires, Carolina Conceição, Rita Ferreira, Quirina Santos-Costa, Elsa Anes, José Miguel Azevedo-Pereira
Publikováno v:
Viruses, Vol 15, Iss 5, p 1030 (2023)
Macrophages (Mø) and dendritic cells (DCs) are key players in human immunodeficiency virus (HIV) infection and pathogenesis. They are essential for the spread of HIV to CD4+ T lymphocytes (TCD4+) during acute infection. In addition, they constitute
Externí odkaz:
https://doaj.org/article/a08003afa1d1452d9d25d8f1c056e0fa
Autor:
David Pires, Manoj Mandal, Ana I. Matos, Carina Peres, Maria João Catalão, José Miguel Azevedo-Pereira, Ronit Satchi-Fainaro, Helena F. Florindo, Elsa Anes
Publikováno v:
Antibiotics, Vol 12, Iss 4, p 729 (2023)
The golden age of antibiotics for tuberculosis (TB) is marked by its success in the 1950s of the last century. However, TB is not under control, and the rise in antibiotic resistance worldwide is a major threat to global health care. Understanding th
Externí odkaz:
https://doaj.org/article/fd4ab8f8cb614e7bbe58b5d7533af708
Autor:
José Miguel Azevedo-Pereira, David Pires, Marta Calado, Manoj Mandal, Quirina Santos-Costa, Elsa Anes
Publikováno v:
Microorganisms, Vol 11, Iss 4, p 853 (2023)
Human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (Mtb) are pathogens responsible for millions of new infections each year; together, they cause high morbidity and mortality worldwide. In addition, late-stage HIV infection increases t
Externí odkaz:
https://doaj.org/article/981aa32cedf041fc8f8a862f9f34afdc
Autor:
David Pires, Manoj Mandal, Jacinta Pinho, Maria João Catalão, António José Almeida, José Miguel Azevedo-Pereira, Maria Manuela Gaspar, Elsa Anes
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 1142 (2023)
Mycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replicat
Externí odkaz:
https://doaj.org/article/44660416d6b9439dbdca8b7fc584998f