Výsledky vyhledávání - "José Maria Alvarez"

Akademický článek

Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection

Autor: Marcela Hernández-Torres, Rogério Silva do Nascimento, Monica Cardozo Rebouças, Alexandra Cassado, Kely Catarine Matteucci, Maria Regina D’Império-Lima, José Ronnie C. Vasconcelos, Karina R. Bortoluci, José Maria Alvarez, Gustavo P. Amarante-Mendes

Publikováno v: Cell Death and Disease, Vol 12, Iss 7, Pp 1-8 (2021)

Abstract Chagas disease is a life-threatening disorder caused by the protozoan parasite Trypanosoma cruzi. Parasite-specific antibodies, CD8+ T cells, as well as IFN-γ and nitric oxide (NO) are key elements of the adaptive and innate immunity agains

Externí odkaz: https://doaj.org/article/2c6b3786ec0642e3842473ee3f88b295

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Akademický článek

P2x7 Receptor Signaling Blockade Reduces Lung Inflammation and Necrosis During Severe Experimental Tuberculosis

Autor: Igor Santiago-Carvalho, Gislane de Almeida-Santos, Caio César Barbosa Bomfim, Paula Carolina de Souza, Juan Carlo Santos e Silva, Bruno Marcel Silva de Melo, Eduardo Pinheiro Amaral, Marcos Vinícios Pinheiro Cione, Elena Lasunskaia, Mario Hiroyuki Hirata, José Carlos Farias Alves-Filho, Helder Imoto Nakaya, José Maria Alvarez, Maria Regina D’Império Lima

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2021)

The risk of developing severe forms of tuberculosis has increased by the acquired immunodeficiency syndrome (AIDS) epidemic, lack of effective drugs to eliminate latent infection and the emergence of drug-resistant mycobacterial strains. Excessive in

Externí odkaz: https://doaj.org/article/0459df50471e4c09ad1ceb32c6c0b30a

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Akademický článek

Correction: Absence of Bim sensitizes mice to experimental Trypanosoma cruzi infection

Publikováno v: Cell Death and Disease, Vol 12, Iss 9, Pp 1-1 (2021)

Externí odkaz: https://doaj.org/article/4bc4dd84383b44c9af1c15a61831fd1a

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Akademický článek

TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria

Autor: Renato Barboza, Flávia Afonso Lima, Aramys Silva Reis, Oscar Javier Murillo, Erika Paula Machado Peixoto, Carla Letícia Bandeira, Wesley Luzetti Fotoran, Luis Roberto Sardinha, Gerhard Wunderlich, Estela Bevilacqua, Maria Regina D’Império Lima, José Maria Alvarez, Fabio Trindade Maranhão Costa, Lígia Antunes Gonçalves, Sabrina Epiphanio, Claudio Romero Farias Marinho

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)

Abstract Malaria-associate pregnancy has a significant impact on infant morbidity and mortality. The detrimental effects of malaria infection during pregnancy have been shown to correlate with immune activation in the placental tissue. Herein we soug

Externí odkaz: https://doaj.org/article/50608ad8eaf04672a8ab0ac58a586af4

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Akademický článek

Programmed Cell Death Protein 1–PDL1 Interaction Prevents Heart Damage in Chronic Trypanosoma cruzi Infection

Autor: Raíssa Fonseca, Rafael Moysés Salgado, Henrique Borges da Silva, Rogério Silva do Nascimento, Maria Regina D’Império-Lima, José Maria Alvarez

Publikováno v: Frontiers in Immunology, Vol 9 (2018)

Chagas disease is a neglected parasitic infection that affects around six to seven million people, mainly in Latin America. About 30–35% of infected people present chronic Chagas cardiomyopathy (CCC), which eventually leads to death. This condition

Externí odkaz: https://doaj.org/article/809f2e7cabd14fb1a8201ed9f8decfae

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Akademický článek

P2X7 receptor drives Th1 cell differentiation and controls the follicular helper T cell population to protect against Plasmodium chabaudi malaria.

Autor: Érika Machado de Salles, Maria Nogueira de Menezes, Renan Siqueira, Henrique Borges da Silva, Eduardo Pinheiro Amaral, Sheyla Inés Castillo-Méndez, Isabela Cunha, Alexandra Dos Anjos Cassado, Flávia Sarmento Vieira, David Nicholas Olivieri, Carlos Eduardo Tadokoro, José Maria Alvarez, Robson Coutinho-Silva, Maria Regina D'Império-Lima

Publikováno v: PLoS Pathogens, Vol 13, Iss 8, p e1006595 (2017)

A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria. However, it is still unclear whether recognition of damage signals influences the immune respo

Externí odkaz: https://doaj.org/article/31e8f2ff44b54faa838b5c1ebfaee342

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Akademický článek

The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice.

Autor: Luiz Roberto Sardinha, Tainá Mosca, Rosa Maria Elias, Rogério Silva do Nascimento, Lígia A Gonçalves, Daniella Zanetti Bucci, Cláudio Romero Farias Marinho, Carlos Penha-Gonçalves, Maria Regina D'Império Lima, José Maria Alvarez

Publikováno v: PLoS Neglected Tropical Diseases, Vol 4, Iss 1, p e578 (2010)

Intravenous challenge with Trypanosoma cruzi can be used to investigate the process and consequences of blood parasite clearance in experimental Chagas disease. One hour after intravenous challenge of chronically infected mice with 5x10(6) trypomasti

Externí odkaz: https://doaj.org/article/420c1cbe5d7f445688450321921ad5b6

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