Zobrazeno 1 - 10
of 1 399
pro vyhledávání: '"José Marco"'
Autor:
Ghada Ben Ameur, Emna Maalej, Helene Martin, Anne-Sophie Jacquinot, Nadine Barbanneau, Paul J. Bernard, José Marco-Contelles, Fakher Chabchoub, Lhassane Ismaili
Publikováno v:
Chemistry, Vol 6, Iss 4, Pp 695-705 (2024)
Eleven new differently substituted N,7-diphenylpyrimido [4,5-d]pyrimidin-4-amines 4a–k were synthesized from readily available reagents in a simple and inexpensive two-step procedure with yields up to 57%. Neuroprotective analysis against H2O2 and
Externí odkaz:
https://doaj.org/article/9019af1564a9476d973ff43077d4706c
Autor:
Sara Izquierdo-Bermejo, Beatriz Chamorro, María Dolores Martín-de-Saavedra, Miguel Lobete, Francisco López-Muñoz, José Marco-Contelles, María Jesús Oset-Gasque
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 946 (2024)
Stroke is a leading cause of death worldwide, yet current therapeutic strategies remain limited. Among the neuropathological events underlying this disease are multiple cell death signaling cascades, including autophagy. Recent interest has focused o
Externí odkaz:
https://doaj.org/article/d9478485d231404bbf591287465f9ff5
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 5908 (2024)
The synthesis, antioxidant capacity, and anti-inflammatory activity of four novel N-benzyl-2-[4-(aryl)-1H-1,2,3-triazol-1-yl]ethan-1-imine oxides 10a–d are reported herein. The nitrones 10a–d were tested for their antioxidant properties and their
Externí odkaz:
https://doaj.org/article/6cbe12a7bf744e52be41d41d68e43811
Autor:
Dora Kolić, Goran Šinko, Ludovic Jean, Mourad Chioua, José Dias, José Marco-Contelles, Zrinka Kovarik
Publikováno v:
Biomolecules, Vol 14, Iss 5, p 588 (2024)
Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the blood–brain barrier, and has demonstrated excellent safety and tolerability properties in clinical research. These characteristics indicate it may serve as
Externí odkaz:
https://doaj.org/article/1e994057bca340fcb598ef7d7a44f256
Autor:
José Marco-Contelles
Publikováno v:
Antioxidants, Vol 13, Iss 4, p 440 (2024)
The recent advances in research on the use of the antioxidant and neuroprotective agent α-phenyl-N-tert-butylnitrone (PBN) for the therapy of stroke have been reviewed. The protective effect of PBN in the transient occlusion of the middle cerebral a
Externí odkaz:
https://doaj.org/article/2da5d52d7f8e4aef896f30efe598f430
Autor:
Beatriz Chamorro, Sara Izquierdo-Bermejo, Julia Serrano, Dimitra Hadjipavlou-Litina, Mourad Chioua, Francisco López-Muñoz, José Marco-Contelles, Ricardo Martínez-Murillo, María Jesús Oset-Gasque
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Cerebral ischemia is a condition affecting an increasing number of people worldwide, and the main cause of disability. Current research focuses on the search for neuroprotective drugs for its treatment, based on the molecular targets involve
Externí odkaz:
https://doaj.org/article/cfd84adb79f24477b7bc1bf3cf4176f0
Autor:
Zofia Chrienova, Eugenie Nepovimova, Rudolf Andrys, Rafael Dolezal, Jana Janockova, Lubica Muckova, Lenka Fabova, Ondrej Soukup, Patrik Oleksak, Martin Valis, Jan Korabecny, José Marco-Contelles, Kamil Kuca
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 2605-2620 (2022)
Twenty-four novel compounds bearing tetrahydroacridine and N-propargyl moieties have been designed, synthesised, and evaluated in vitro for their anti-cholinesterase and anti-monoamine oxidase activities. Propargyltacrine 23 (IC50 = 21 nM) was the mo
Externí odkaz:
https://doaj.org/article/1b4b604d4ed2463eadfec515d42a5564
Publikováno v:
Heliyon, Vol 8, Iss 10, Pp e11165- (2022)
Background: Intellectual disabilities (ID) cause problems in intellectual and adaptive functioning which negatively affect motor proficiency levels. Aim: This study investigates the impact of a motor intervention programme on the motor proficiency le
Externí odkaz:
https://doaj.org/article/ed179c0460cb423faf74033e951a6537
Autor:
Emelina R. Rodríguez-Ruiz, Raquel Herrero-Labrador, Ana P. Fernández-Fernández, Julia Serrano-Masa, José A. Martínez-Montero, Daniel González-Nieto, Mayuri Hana-Vaish, Mohamed Benchekroun, Lhassane Ismaili, José Marco-Contelles, Ricardo Martínez-Murillo
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12254 (2023)
Great effort has been devoted to the synthesis of novel multi-target directed tacrine derivatives in the search of new treatments for Alzheimer’s disease (AD). Herein we describe the proof of concept of MBA121, a compound designed as a tacrine–fe
Externí odkaz:
https://doaj.org/article/dbe06503d32d4410b60bea940048ddc2