Raloxifene and n-Acetylcysteine Ameliorate TGF-Signalling in Fibroblasts from Patients with Recessive Dominant Epidermolysis Bullosa

Autor: Tania Aguado, Marta García, Adela García, Gemma Ferrer-Mayorga, Lucía Martínez-Santamaría, Marcela del Río, Luisa-María Botella, José-María Sánchez-Puelles

Publikováno v: Cells, Vol 9, Iss 9, p 2108 (2020)

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe skin disease caused by mutation of the COL7A1 gene. RDEB is associated with high levels of TGF-β1, which is likely to be involved in the fibrosis that develops in this disease. Endoglin (

Externí odkaz: https://doaj.org/article/a7bae1e81a544c68a49d8af94b5b9af8

Multifunctional albumin-stabilized gold nanoclusters for the reduction of cancer stem cells

Autor: Álvaro Somoza, Ana Latorre, Mercedes Lecea, Milagros Castellanos, José María Sánchez-Puelles, Ciro Rodriguez Diaz, Angeles Villanueva, Sonia Romero-Pérez, Alfonso Latorre, Tania Aguado, Ana Lazaro-Carrillo, Macarena Calero

Publikováno v: Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Cancers
Digital.CSIC. Repositorio Institucional del CSIC
Volume 11
Issue 7
Cancers, Vol 11, Iss 7, p 969 (2019)
Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia

© The Author(s).
Controlled delivery of multiple chemotherapeutics can improve the effectiveness of treatments and reduce side effects and relapses. Here in, we used albumin-stabilized gold nanoclusters modified with doxorubicin and SN38 (AuNCs

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b163aa6a0da19e77bca708d45fcb11e0
http://hdl.handle.net/10486/689973

Amperometric determination of endoglin in human serum using disposable immunosensors constructed with poly(pyrrolepropionic) acid-modified electrodes

Autor: Lucía Martínez-Santamaría, Araceli González-Cortés, José M. Pingarrón, Susana Campuzano, E. Sánchez-Tirado, Emiliano Martínez-Periñán, Rodrigo Barderas, P. Yáñez-Sedeño, José María Sánchez-Puelles

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname

24 p.-6 fig.-2 tab.
An amperometric immunosensor for the determination of the biomarker endoglin (CD105) to comply with the requirements of sensitivity and accuracy demanded in clinical practice is reported in this work. The immunosensing platfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374f456a0c933fa01acf88182a5860a3
http://hdl.handle.net/10261/171261

Frailty Is Associated With Lower Expression of Genes Involved in Cellular Response to Stress: Results From the Toledo Study for Healthy Aging

Autor: José-María Sánchez-Puelles, Mariam El Assar, José A. Carnicero, Javier C. Angulo, Eva López-Hernández, Stefan Walter, Francisco José García-García, Leocadio Rodríguez-Mañas

Publikováno v: Journal of the American Medical Directors Association. 18(8)

Background Specific mechanisms underlying frailty syndrome are not well known. Frailty can be viewed as a loss of functional reserve resulting in increased vulnerability to stressors. We hypothesize that pathways regulating cellular response to stres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2cc375be177829a48e54661f7e9f0bc
https://pubmed.ncbi.nlm.nih.gov/28647579

Magnetobiosensors Based on Viral Protein p19 for MicroRNA Determination in Cancer Cells and Tissues

Autor: Susana Campuzano, José M. Pingarrón, Eva López-Hernández, Rebeca M. Torrente-Rodríguez, Rosario Granados, José María Sánchez-Puelles, Felipe Conzuelo

Publikováno v: Angewandte Chemie. 126:6282-6285

MicroRNAs (miRs) have emerged as important clinical biomarkers with both diagnostic and prognostic value for relevant diseases, such as cancer. MiRs pose unique challenges for detection and are currently detected by northern blotting, real-time PCR,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01af6e7993ad2932978f689fa9a88030
https://doi.org/10.1002/ange.201403270