Zobrazeno 1 - 10
of 22
pro vyhledávání: '"José Manuel Perez-Garcia"'
Autor:
Sara A Hurvitz, Roberto Hegg, Wei-Pang Chung, Seock-Ah Im, William Jacot, Vinod Ganju, Joanne Wing Yan Chiu, Binghe Xu, Erika Hamilton, Srinivasan Madhusudan, Hiroji Iwata, Sevilay Altintas, Jan-Willem Henning, Giuseppe Curigliano, José Manuel Perez-Garcia, Sung-Bae Kim, Vanessa Petry, Chiun-Sheng Huang, Wei Li, Jean-Sebastien Frenel, Silvia Antolin, Winnie Yeo, Giampaolo Bianchini, Sherene Loi, Junji Tsurutani, Anton Egorov, Yali Liu, Jillian Cathcart, Shahid Ashfaque, Javier Cortés
Publikováno v:
The lancet : international edition
Background An improvement in progression-free survival was shown with trastuzumab deruxtecan versus trastuzumab emtansine in patients with HER2-positive metastatic breast cancer in the progression-free survival interim analysis of the DESTINY-Breast0
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f34ca39bb4e6f5a2f1a4d78197528f6d
https://doi.org/10.1016/s0140-6736(22)02420-5
https://doi.org/10.1016/s0140-6736(22)02420-5
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Pharmacokinetics: Z-endoxifen levels per taselisib dose level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b8c3ce186a1e98a096fd80e837ef085
https://doi.org/10.1158/1078-0432.22471986.v1
https://doi.org/10.1158/1078-0432.22471986.v1
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Purpose:The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)–positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed. Taselisib is a po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38dbcd046b3ffe289c7694d6875e0bdd
https://doi.org/10.1158/1078-0432.c.6528075
https://doi.org/10.1158/1078-0432.c.6528075
Autor:
Sabine C. Linn, Carlos Caldas, Javier Cortès, William Gallagher, Cristina Saura, René Bernards, Aurelia de Vries Schultink, Margaret Schot, Petra Nederlof, Else Platte, Hilde Rosing, José-Manuel Perez-Garcia, Emma Beddowes, Maurizio Callari, Harm van Tinteren, Sanjeev Kumar, Constanza Linossi, Erik van Werkhoven, Greig Dougall, Anne-Laure Vallier, Javier Garcia-Corbacho, Ingrid A.M. Mandjes, Mariette Schrier, Meiling Gao, Karin Beelen, Mafalda Oliveira, Annelot G.J. van Rossum, Richard D. Baird
Supplementary Methods Text
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1182c2cadec2b5dc324fec46d078953
https://doi.org/10.1158/1078-0432.22471977.v1
https://doi.org/10.1158/1078-0432.22471977.v1
Akademický článek
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Autor:
José Enrique Alés-Martínez, Judith Balmaña, Pedro Sánchez-Rovira, Francisco Javier Salvador Bofill, Jose Ángel García Sáenz, Isabel Pimentel, Serafín Morales, María Fernández-Abad, Ainhara Lahuerta Martínez, Neus Ferrer, Pilar Zamora, Begoña Bermejo, Tamara Díaz-Redondo, María Helena López-Ceballos, María Galán, Jhudit Pérez-Escuredo, Laura Calabuig, Miguel Sampayo, José Manuel Pérez-Garcia, Javier Cortés, Antonio Llombart-Cussac
Publikováno v:
Breast, Vol 77, Iss , Pp 103780- (2024)
Purpose: To evaluate the efficacy and safety of the combination of olaparib plus trastuzumab in patients with HER2-positive advanced breast cancer (ABC) and germinal BRCA mutations (gBRCAm). Methods: OPHELIA (NCT03931551) was a single-arm, open-label
Externí odkaz:
https://doaj.org/article/19f49dc9a9694e038d227468d5e24fe9
Autor:
Serena Di Cosimo, José Manuel Pérez-García, Meritxell Bellet, Florence Dalenc, Miguel J. Gil Gil, Manuel Ruiz-Borrego, Joaquín Gavilá, Elena Aguirre, Peter Schmid, Frederik Marmé, Joseph Gligorov, Andreas Schneeweiss, Joan Albanell, Pilar Zamora, Duncan Wheatley, Eduardo Martínez de Dueñas, Kepa Amillano, Eileen Shimizu, Miguel Sampayo-Cordero, Javier Cortés, Antonio Llombart-Cussac
Publikováno v:
Breast, Vol 76, Iss , Pp 103761- (2024)
Background: The capsule formulation of CDK4/6 inhibitor palbociclib has reduced solubility at gastric pH > 4.5 and may have decreased activity when used with proton-pump inhibitors (PPI). Herein, we report the effect of PPI on palbociclib capsule act
Externí odkaz:
https://doaj.org/article/d3b96315025744e9a531e42906d8d57a
Autor:
Antonio Llombart-Cussac, José Manuel Pérez-Garcia, Manuel Ruiz Borrego, Pablo Tolosa, Salvador Blanch, Adela Fernández-Ortega, Ander Urruticoechea, Isabel Blancas, Cristina Saura, Beatriz Rojas, Begoña Bermejo, José Ponce Lorenzo, María Gion, Patricia Cortez-Castedo, Elisenda Llabres, Elena Galve, Juan Fernando Cueva, Ana López, José Luis Alonso-Romero, Santiago González-Santiago, Eduardo Martínez de Dueñas, Eva Ciruelos, Griselda Martrat, Petra Gener, Daniel Alcalá-López, Miguel Sampayo-Cordero, Fernando Gómez-Peralta, Javier Cortés
Publikováno v:
EClinicalMedicine, Vol 71, Iss , Pp 102520- (2024)
Summary: Background: Hyperglycaemia is an early and frequent adverse event during alpelisib treatment. METALLICA aimed to evaluate prophylactic metformin to prevent or reduce hyperglycaemia occurrence in patients with HR+/HER2−/PIK3CA-mutated advan
Externí odkaz:
https://doaj.org/article/c5ba8bd9a6864624b463e00529accd71
Autor:
Matilde Sánchez-Conde, Pilar Vizcarra, José Manuel Pérez-García, María Gion, María Pilar Martialay, Javier Taboada, Alberto Alonso-Fernández, Miguel Sampayo-Cordero, Andrea Malfettone, Isabel Tena, Sergio De La Torre, Antonio Llombart-Cussac, Javier Cortés
Publikováno v:
International Journal of Infectious Diseases, Vol 123, Iss , Pp 97-103 (2022)
Objectives: Severe COVID-19 is associated with immune dysregulation and hyperinflammation (lymphocyte exhaustion and elevated interleukin 6. Pembrolizumab (P; immune-activating anti-programmed cell death-1 antibody) plus tocilizumab (TCZ; anti- inter
Externí odkaz:
https://doaj.org/article/03300a66cee940b7bc9b769d46d85504
Autor:
Miguel Sampayo-Cordero, Bernat Miguel-Huguet, Andrea Malfettone, Elena López-Miranda, María Gion, Elena Abad, Daniel Alcalá-López, Jhudit Pérez-Escuredo, José Manuel Pérez-García, Antonio Llombart-Cussac, Javier Cortés
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
De-escalation trials in oncology evaluate therapies that aim to improve the quality of life of patients with low-risk cancer by avoiding overtreatment. Non-inferiority randomized trials are commonly used to investigate de-intensified regimens with si
Externí odkaz:
https://doaj.org/article/4129d5abe3b54a4aa1163a0967a18f28