Zobrazeno 1 - 10
of 14
pro vyhledávání: '"José Manuel González-Ros"'
Publikováno v:
Membranes, Vol 12, Iss 10, p 986 (2022)
The use of Xenopus oocytes in electrophysiological and biophysical research constitutes a long and successful story, providing major advances to the knowledge of the function and modulation of membrane proteins, mostly receptors, ion channels, and tr
Externí odkaz:
https://doaj.org/article/2b2947590c2f4797a91a09b10231e00e
Autor:
Ana Marcela Giudici, María Lourdes Renart, Ana Coutinho, Andrés Morales, José Manuel González-Ros, José Antonio Poveda
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9246 (2022)
Y55W mutants of non-selective NaK and partly K+-selective NaK2K channels have been used to explore the conformational dynamics at the pore region of these channels as they interact with either Na+ or K+. A major conclusion is that these channels exhi
Externí odkaz:
https://doaj.org/article/4db73d378a844da6839f0f452d3c4f84
Autor:
Armando Alberola-Die, José Antonio Encinar, Raúl Cobo, Gregorio Fernández-Ballester, José Manuel González-Ros, Isabel Ivorra, Andrés Morales
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 20, p 11287 (2021)
Fritillaria bulbs are used in Traditional Chinese Medicine to treat several illnesses. Peimine (Pm), an anti-inflammatory compound from Fritillaria, is known to inhibit some voltage-dependent ion channels and muscarinic receptors, but its interaction
Externí odkaz:
https://doaj.org/article/fe106dda45f64b919f7a013e1299f066
Autor:
Ana Marcela Giudici, Maria Lourdes Renart, Clara Díaz-García, Andrés Morales, José Antonio Poveda, José Manuel González-Ros
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 3, p 689 (2019)
Cation binding under equilibrium conditions has been used as a tool to explore the accessibility of permeant and nonpermeant cations to the selectivity filter in three different inactivated models of the potassium channel KcsA. The results show that
Externí odkaz:
https://doaj.org/article/86b7859e34e842259793ae2717a6e417
Autor:
Armando Alberola-Die, Gregorio Fernandez-Ballester, José Manuel González-Ros, Isabel Ivorra, Andrés Morales
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
To identify the molecular determinants responsible for lidocaine blockade of muscle-type nAChRs, we have studied the effects on this receptor of 2,6-dimethylaniline (DMA), which resembles lidocaine’s hydrophobic moiety. Torpedo marmorata nAChRs wer
Externí odkaz:
https://doaj.org/article/12f1d81ad51c4a6592ced6ef71b091e5
Autor:
Armando eAlberola-Die, Gregorio eFernandez-Ballester, José Manuel González-Ros, Isabel eIvorra, Andrés eMorales
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 9 (2016)
Lidocaine bears in its structure both an aromatic ring and a terminal amine, which can be protonated at physiological pH, linked by an amide group. Since lidocaine causes multiple inhibitory actions on nicotinic acetylcholine receptors (nAChRs), this
Externí odkaz:
https://doaj.org/article/70330df296324619b75fc0050d6feba1
Autor:
Antonio Ferrer-Montiel, José Manuel González-Ros, Isabel Devesa, Asia Fernández-Carvajal, Gregorio Fernández-Ballester
Publikováno v:
Pharmaceuticals, Vol 5, Iss 1, Pp 16-48 (2011)
One approach to develop successful pain therapies is the modulation of dysfunctional ion channels that contribute to the detection of thermal, mechanical and chemical painful stimuli. These ion channels, known as thermoTRPs, promote the sensitization
Externí odkaz:
https://doaj.org/article/72d1de75920345358e2851c4ae56fade
Autor:
José Manuel González-Ros, Antonio Ferrer-Montiel, Gregorio Fernández-Ballester, Asia Fernández-Carvajal
Publikováno v:
Pharmaceutics, Vol 3, Iss 4, Pp 932-953 (2011)
Ion channels are involved in a broad range of physiological and pathological processes. The implications of ion channels in a variety of diseases, including diabetes, epilepsy, hypertension, cancer and even chronic pain, have signaled them as pivotal
Externí odkaz:
https://doaj.org/article/be46905816c44d31bbe2d523c23bcca9
Autor:
Paula Pérez-Faginas, M Teresa Aranda, M Teresa García-López, Lourdes Infantes, Asia Fernández-Carvajal, José Manuel González-Ros, Antonio Ferrer-Montiel, Rosario González-Muñiz
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e53231 (2013)
1,2-Diamine derivatives are valuable building blocks to heterocyclic compounds and important precursors of biologically relevant compounds. In this respect, amino acid-derived β-keto esters are a suitable starting point for the synthesis of β,γ-di
Externí odkaz:
https://doaj.org/article/7dfdae62614e42498e3fa7f83dc0793c
Autor:
Armando, Alberola-Die, Juan, Martinez-Pinna, José Manuel, González-Ros, Isabel, Ivorra, Andrés, Morales
Publikováno v:
Journal of neurochemistry. 117(6)
Lidocaine is a local anaesthetic that blocks sodium channels, but also inhibits several ligand-gated ion-channels. The aim of this work was to unravel the mechanisms by which lidocaine blocks Torpedo nicotinic receptors transplanted to Xenopus oocyte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5d3390d6174cab6947b010c19d87c69a
https://pubmed.ncbi.nlm.nih.gov/21480901
https://pubmed.ncbi.nlm.nih.gov/21480901