Zobrazeno 1 - 10
of 334
pro vyhledávání: '"José Manuel García-Verdugo"'
Neuraminidase inhibition promotes the collective migration of neurons and recovery of brain function
Autor:
Mami Matsumoto, Katsuyoshi Matsushita, Masaya Hane, Chentao Wen, Chihiro Kurematsu, Haruko Ota, Huy Bang Nguyen, Truc Quynh Thai, Vicente Herranz-Pérez, Masato Sawada, Koichi Fujimoto, José Manuel García-Verdugo, Koutarou D Kimura, Tatsunori Seki, Chihiro Sato, Nobuhiko Ohno, Kazunobu Sawamoto
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1228-1253 (2024)
Abstract In the injured brain, new neurons produced from endogenous neural stem cells form chains and migrate to injured areas and contribute to the regeneration of lost neurons. However, this endogenous regenerative capacity of the brain has not yet
Externí odkaz:
https://doaj.org/article/38a75c2192bc4cdea63491e9304280eb
Autor:
Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A. Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and function
Externí odkaz:
https://doaj.org/article/eb78cdc0f8c54c43a0de1c4a96db4c3e
Autor:
Marina Guillén-Yunta, Víctor Valcárcel-Hernández, Ángel García-Aldea, Guadalupe Soria, José Manuel García-Verdugo, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-20 (2023)
Abstract Background The monocarboxylate transporter 8 (MCT8) plays a vital role in maintaining brain thyroid hormone homeostasis. This transmembrane transporter is expressed at the brain barriers, as the blood–brain barrier (BBB), and in neural cel
Externí odkaz:
https://doaj.org/article/0eeb6dae8d194ee1ad7e04172c78f784
Autor:
David Gómez-Fernández, Ana Romero-González, Juan M. Suárez-Rivero, Paula Cilleros-Holgado, Mónica Álvarez-Córdoba, Rocío Piñero-Pérez, José Manuel Romero-Domínguez, Diana Reche-López, Alejandra López-Cabrera, Salvador Ibáñez-Mico, Marta Castro de Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, José A. Sánchez-Alcázar
Publikováno v:
Antioxidants, Vol 13, Iss 8, p 1023 (2024)
Mutations in the lipoyltransferase 1 (LIPT1) gene are rare inborn errors of metabolism leading to a fatal condition characterized by lipoylation defects of the 2-ketoacid dehydrogenase complexes causing early-onset seizures, psychomotor retardation,
Externí odkaz:
https://doaj.org/article/3e5f8306564c49ea85740f0320439a87
Autor:
Emily S. Norton, Lauren A. Whaley, María José Ulloa-Navas, Patricia García-Tárraga, Kayleah M. Meneses, Montserrat Lara-Velazquez, Natanael Zarco, Anna Carrano, Alfredo Quiñones-Hinojosa, José Manuel García-Verdugo, Hugo Guerrero-Cázares
Publikováno v:
Fluids and Barriers of the CNS, Vol 19, Iss 1, Pp 1-15 (2022)
Abstract Background Glioblastoma (GBM) is the most aggressive and common type of primary brain tumor in adults. Tumor location plays a role in patient prognosis, with tumors proximal to the lateral ventricles (LVs) presenting with worse overall survi
Externí odkaz:
https://doaj.org/article/9cadd866c9ba4321b8612168ad7dad64
Autor:
Susana González-Granero, Enrique Font, Ester Desfilis, Vicente Herranz-Pérez, José Manuel García-Verdugo
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
In adult lizards, new neurons are generated from neural stem cells in the ventricular zone of the lateral ventricles. These new neurons migrate and integrate into the main telencephalic subdivisions. In this work we have studied adult neurogenesis in
Externí odkaz:
https://doaj.org/article/1a7c1348bdd643d1ae48490613190cc9
Autor:
Alejandra Suárez-Carrillo, Mónica Álvarez-Córdoba, Ana Romero-González, Marta Talaverón-Rey, Suleva Povea-Cabello, Paula Cilleros-Holgado, Rocío Piñero-Pérez, Diana Reche-López, David Gómez-Fernández, José Manuel Romero-Domínguez, Manuel Munuera-Cabeza, Antonio Díaz, Susana González-Granero, José Manuel García-Verdugo, José A. Sánchez-Alcázar
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14576 (2023)
Neurodegeneration with brain iron accumulation (NBIA) is a group of rare neurogenetic disorders frequently associated with iron accumulation in the basal nuclei of the brain. Among NBIA subtypes, β-propeller protein-associated neurodegeneration (BPA
Externí odkaz:
https://doaj.org/article/9219c7aa7c0a4264b7ee2a42d6da8dc4
Autor:
Cristina Cueto-Ureña, Enric Mocholí, Josep Escrivá-Fernández, Susana González-Granero, Sabina Sánchez-Hernández, Amalia Solana-Orts, Begoña Ballester-Lurbe, Karim Benabdellah, Rosa M. Guasch, José Manuel García-Verdugo, Francisco Martín, Paul J. Coffer, Ignacio Pérez-Roger, Enric Poch
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Autophagy is a highly conserved process that mediates the targeting and degradation of intracellular components to lysosomes, contributing to the maintenance of cellular homeostasis and to obtaining energy, which ensures viability under stress condit
Externí odkaz:
https://doaj.org/article/7de0449f54f5452689bd32359d3d685e
Autor:
Gabriela Edwards-Faret, Karina González-Pinto, Arantxa Cebrián-Silla, Johany Peñailillo, José Manuel García-Verdugo, Juan Larraín
Publikováno v:
Neural Development, Vol 16, Iss 1, Pp 1-25 (2021)
Abstract Background The efficient regenerative abilities at larvae stages followed by a non-regenerative response after metamorphosis in froglets makes Xenopus an ideal model organism to understand the cellular responses leading to spinal cord regene
Externí odkaz:
https://doaj.org/article/4a09e9ecf7464f0f83a8f171bac05e04
Autor:
Inés Berrosteguieta, Juan Carlos Rosillo, María Laura Herrera, Silvia Olivera-Bravo, Gabriela Casanova, Vicente Herranz-Pérez, José Manuel García-Verdugo, Anabel Sonia Fernández
Publikováno v:
Current Research in Neurobiology, Vol 3, Iss , Pp 100042- (2022)
Austrolebias annual fishes exhibit cell proliferation and neurogenesis throughout life. They withstand extreme environmental changes as their habitat dries out, pressuring nervous system to adapt. Their visual system is challenged to adjust as the wa
Externí odkaz:
https://doaj.org/article/da7507a3a9e64ee3ac46d2f9c171ecf1