Interlocking of co-opted developmental gene networks in Drosophila and the evolution of pre-adaptive novelty

Autor: Sara Molina-Gil, Sol Sotillos, José Manuel Espinosa-Vázquez, Isabel Almudi, James C.-G. Hombría

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)

Abstract The re-use of genes in new organs forms the base of many evolutionary novelties. A well-characterised case is the recruitment of the posterior spiracle gene network to the Drosophila male genitalia. Here we find that this network has also be

Externí odkaz: https://doaj.org/article/ad476aafdcf94efc82f19b11988a9064

Specification of the endocrine primordia controlling insect moulting and metamorphosis by the JAK/STAT signalling pathway.

Autor: Mar García-Ferrés, Carlos Sánchez-Higueras, Jose Manuel Espinosa-Vázquez, James C-G Hombría

Publikováno v: PLoS Genetics, Vol 18, Iss 10, p e1010427 (2022)

The corpora allata and the prothoracic glands control moulting and metamorphosis in insects. These endocrine glands are specified in the maxillary and labial segments at positions homologous to those forming the trachea in more posterior segments. Gl

Externí odkaz: https://doaj.org/article/524bc9b1053146319cbeef5358a3b8f3

Antagonism versus cooperativity with TALE cofactors at the base of the functional diversification of Hox protein function

Autor: Nagraj Sambrani, James Castelli-Gair Hombría, Stephen Greig, Yacine Graba, José Manuel Espinosa-Vázquez, Samir Merabet, María Luisa Rivas

Publikováno v: PLoS Genetics
PLoS Genetics, 2013, 9 (2), pp.e1003252. ⟨10.1371/journal.pgen.1003252⟩
PLoS Genetics, Vol 9, Iss 2, p e1003252 (2013)
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PLoS Genetics, Public Library of Science, 2013, 9 (2), pp.e1003252. ⟨10.1371/journal.pgen.1003252⟩

This is an open-access article distributed under the terms of the Creative Commons Attribution License.
Extradenticle (Exd) and Homothorax (Hth) function as positive transcriptional cofactors of Hox proteins, helping them to bind specifically th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b79f0f444962d1720bee844f45e02a
https://hal.science/hal-00862286/file/journal.pgen.1003252.PDF

JAK/STAT and Hox Dynamic Interactions in an Organogenetic Gene Cascade.

Autor: Pedro B Pinto, Jose Manuel Espinosa-Vázquez, María Luísa Rivas, James Castelli-Gair Hombría

Publikováno v: PLoS Genetics, Vol 11, Iss 7, p e1005412 (2015)

Organogenesis is controlled by gene networks activated by upstream selector genes. During development the gene network is activated stepwise, with a sequential deployment of successive transcription factors and signalling molecules that modify the in

Externí odkaz: https://doaj.org/article/2f8799e0b8784d78a1ae95f4fdccabf3

Antagonism versus cooperativity with TALE cofactors at the base of the functional diversification of Hox protein function.

Autor: María Luisa Rivas, Jose Manuel Espinosa-Vázquez, Nagraj Sambrani, Stephen Greig, Samir Merabet, Yacine Graba, James Castelli-Gair Hombría

Publikováno v: PLoS Genetics, Vol 9, Iss 2, p e1003252 (2013)

Extradenticle (Exd) and Homothorax (Hth) function as positive transcriptional cofactors of Hox proteins, helping them to bind specifically their direct targets. The posterior Hox protein Abdominal-B (Abd-B) does not require Exd/Hth to bind DNA; and,

Externí odkaz: https://doaj.org/article/781a512d46c14bdcb723e4e51316bd17