Zobrazeno 1 - 10
of 108
pro vyhledávání: '"José Manuel Bravo-San Pedro"'
Autor:
Jiayin Deng, Lucía G. Gutiérrez, Gautier Stoll, Omar Motiño, Isabelle Martins, Lucía Núñez, José Manuel Bravo-San Pedro, Juliette Humeau, Chloé Bordenave, Juncheng Pan, Hélène Fohrer-Ting, Sylvie Souquere, Gerard Pierron, Claudio Hetz, Carlos Villalobos, Guido Kroemer, Laura Senovilla
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Abstract Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial outer membrane permeabilization (MOMP), which is the rate-limiting step of the intrinsic pat
Externí odkaz:
https://doaj.org/article/b8e22883032443a5aba0575cbed66635
Autor:
Léa Montégut, Hui Chen, José Manuel Bravo-San Pedro, Omar Motiño, Isabelle Martins, Guido Kroemer
Publikováno v:
STAR Protocols, Vol 3, Iss 1, Pp 101095- (2022)
Summary: Keyhole limpet hemocyanin (KLH) is a glycosylated multi-subunit metalloprotein that elicits a strong nonspecific immune activation, thus inducing both cellular and humoral immune responses. The exceptional immunogenicity of this protein can
Externí odkaz:
https://doaj.org/article/2ad83389fe33456582f6d37b04f4fce6
Autor:
Estefanie Dufey, José Manuel Bravo-San Pedro, Cristian Eggers, Matías González-Quiroz, Hery Urra, Alfredo I. Sagredo, Denisse Sepulveda, Philippe Pihán, Amado Carreras-Sureda, Younis Hazari, Eduardo A. Sagredo, Daniela Gutierrez, Cristian Valls, Alexandra Papaioannou, Diego Acosta-Alvear, Gisela Campos, Pedro M. Domingos, Rémy Pedeux, Eric Chevet, Alejandra Alvarez, Patricio Godoy, Peter Walter, Alvaro Glavic, Guido Kroemer, Claudio Hetz
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
IRE1α plays a key role in the unfolded protein response (UPR) by promoting the unconventional splicing of the XBP1 and the selective cleavage of RNAs. Here the authors report that IRE1α is activated upon the DNA damage response and selectively cont
Externí odkaz:
https://doaj.org/article/41bd77e35d0d4d3fba7541fc5ffc6412
Publikováno v:
Cell Stress, Vol 3, Iss 10, Pp 312-318 (2019)
The best-known appetite-regulating factors identified in rodents are leptin, an appetite inhibitor, and ghrelin, an appetite stimulator. Rare cases of loss-of-functions mutations affecting leptin and its receptor, as well as polymorphisms concerning
Externí odkaz:
https://doaj.org/article/ecd5142027aa46fe9d39f48135bf6b0b
Autor:
Ernesto Martínez-Martínez, Joaquín Fernández-Irigoyen, Enrique Santamaría, María Luisa Nieto, José Manuel Bravo-San Pedro, Victoria Cachofeiro
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8080 (2022)
A proteomic approach was used to characterize potential mediators involved in the improvement in cardiac fibrosis observed with the administration of the mitochondrial antioxidant MitoQ in obese rats. Male Wistar rats were fed a standard diet (3.5% f
Externí odkaz:
https://doaj.org/article/bffcfdec37864b08b77b62278c6d0e44
Autor:
Gerasimos Anagnostopoulos, Omar Motiño, Sijing Li, Vincent Carbonnier, Hui Chen, Valentina Sica, Sylvère Durand, Mélanie Bourgin, Fanny Aprahamian, Nitharsshini Nirmalathasan, Romain Donne, Chantal Desdouets, Marcelo Simon Sola, Konstantina Kotta, Léa Montégut, Flavia Lambertucci, Didier Surdez, Grossetête Sandrine, Olivier Delattre, Maria Chiara Maiuri, José Manuel Bravo-San Pedro, Isabelle Martins, Guido Kroemer
Publikováno v:
Cell Death and Disease, Vol 13, Iss 5, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/079b77792a314dfb93dbcdc0d5aaa91b
Autor:
Rita Del Giudice, Paola Imbimbo, Federico Pietrocola, Isabelle Martins, Fatima Domenica Elisa De Palma, José Manuel Bravo-San Pedro, Guido Kroemer, Maria Chiara Maiuri, Daria Maria Monti
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3498 (2022)
Amyloidoses are characterized by the accumulation and aggregation of misfolded proteins into fibrils in different organs, leading to cell death and consequent organ dysfunction. The specific substitution of Leu 75 for Pro in Apolipoprotein A-I protei
Externí odkaz:
https://doaj.org/article/bcc3f4a3158a4b7696814b0b06312953
Publikováno v:
Molecular & Cellular Oncology, Vol 6, Iss 6 (2019)
Paradoxically, most if not all previously known appetite-stimulatory hormones are downregulated in human obesity, reflecting failing homeostatic circuitries. Recently, we discovered that acyl-coenzyme-A binding protein/diazepam-binding inhibitor (ACB
Externí odkaz:
https://doaj.org/article/d82c706321b345bfa31132d3df15e6d1
Publikováno v:
Antioxidants, Vol 10, Iss 1, p 102 (2021)
Reactive oxygen species (ROS) operate as key regulators of cellular homeostasis within a physiological range of concentrations, yet they turn into cytotoxic entities when their levels exceed a threshold limit. Accordingly, ROS are an important etiolo
Externí odkaz:
https://doaj.org/article/ca0782e9c6244b8eb33ca8df2df71cfe
Publikováno v:
Cell Reports, Vol 11, Iss 10, Pp 1501-1502 (2015)
In this issue of Cell Reports, Cullen et al. demonstrate that the release of mature interleukin-1β relies on necrotic plasma membrane permeabilization. Thus, caspases may have evolved to modulate the inflammatory potential of cell death, not to exec
Externí odkaz:
https://doaj.org/article/f3b2940d02b84fd58cb48a5cba0314c8