A quantitative systems pharmacology model for certolizumab pegol treatment in moderate-to-severe psoriasis

Autor: Pablo Coto-Segura, Cristina Segú-Vergés, Antonio Martorell, David Moreno-Ramírez, Guillem Jorba, Valentin Junet, Filippo Guerri, Xavier Daura, Baldomero Oliva, Carlos Cara, Olaya Suárez-Magdalena, Sonya Abraham, José Manuel Mas

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

BackgroundPsoriasis is a chronic immune-mediated inflammatory systemic disease with skin manifestations characterized by erythematous, scaly, itchy and/or painful plaques resulting from hyperproliferation of keratinocytes. Certolizumab pegol [CZP], a

Externí odkaz: https://doaj.org/article/9303c230818e4c188b68993bece78e06

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Methods to Develop an in silico Clinical Trial: Computational Head-to-Head Comparison of Lisdexamfetamine and Methylphenidate

Autor: José Ramón Gutiérrez-Casares, Javier Quintero, Guillem Jorba, Valentin Junet, Vicente Martínez, Tamara Pozo-Rubio, Baldomero Oliva, Xavier Daura, José Manuel Mas, Carmen Montoto

Publikováno v: Frontiers in Psychiatry, Vol 12 (2021)

Regulatory agencies encourage computer modeling and simulation to reduce the time and cost of clinical trials. Although still not classified in formal guidelines, system biology-based models represent a powerful tool for generating hypotheses with gr

Externí odkaz: https://doaj.org/article/a6bb124783584afe9bbbde6500ed2a42

Female Sex, Age, and Unfavorable Response to Tumor Necrosis Factor Inhibitors in Patients With Axial Spondyloarthritis: Results of Statistical and Artificial Intelligence–Based Data Analyses of a National Multicenter Prospective Registry

Autor: Cristina Fernández‐Carballido, Carlos Sanchez‐Piedra, Raquel Valls, Kristin Garg, Fernando Sánchez‐Alonso, Laura Artigas, José Manuel Mas, Vega Jovaní, Sara Manrique, Cristina Campos, Mercedes Freire, Olga Martínez‐González, Isabel Castrejón, Chiara Perella, Mireia Coma, Irene E. van der Horst‐Bruinsma

Publikováno v: Arthritis Care & Research, 75, 115-124
Fernández-Carballido, C, Sanchez-Piedra, C, Valls, R, Garg, K, Sánchez-Alonso, F, Artigas, L, Mas, J M, Jovaní, V, Manrique, S, Campos, C, Freire, M, Martínez-González, O, Castrejón, I, Perella, C, Coma, M & van der Horst-Bruinsma, I E 2023, ' Female Sex, Age, and Unfavorable Response to Tumor Necrosis Factor Inhibitors in Patients With Axial Spondyloarthritis : Results of Statistical and Artificial Intelligence–Based Data Analyses of a National Multicenter Prospective Registry ', Arthritis Care and Research, vol. 75, no. 1, pp. 115-124 . https://doi.org/10.1002/acr.25048
Arthritis Care and Research, 75(1), 115-124. John Wiley and Sons Inc.
Arthritis Care & Research, 75, 1, pp. 115-124

Item does not contain fulltext OBJECTIVE: Real-world studies are needed to identify factors associated with response to biologic therapies in patients with axial spondyloarthritis (SpA). The objective was to assess sex differences in response to tumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35141e25b2641c608129b962b4463e71
https://doi.org/10.1002/acr.25048

The usage of transcriptomics datasets as sources of Real-World Data for clinical trialling

Autor: Pedro Matos-Filipe, Juan Manuel García-Illarramendi, Guillem Jorba, Baldo Oliva, Judith Farrés, José Manuel Mas

IntroductionRandomized clinical trials (RCT) are limited in reflecting observable results out of controlled settings, which requires the execution of further lengthy observational studies. The usage of real-world data (RWD) has been recently consider

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4c83d986823550315a277a992afbe93
https://doi.org/10.1101/2022.11.10.515995