Zobrazeno 1 - 10
of 18
pro vyhledávání: '"José Manuel, García-Castellano"'
Autor:
José Manuel García-Castellano, David García-Padrón, Nerea Martínez-Aragón, Margarita Ramírez-Sánchez, Vicente Vera-Gutiérrez, Leandro Fernández-Pérez
Publikováno v:
Tumor Angiogenesis and Modulators
Tumor Angiogenesis and Modulators ISBN: 9781803558349
Tumor Angiogenesis and Modulators ISBN: 9781803558349
Solid tumors, despite being hypervascularized, are hypoxic. This is due to the imbalance that exists between the inputs of the blood vessels that supply nutrients and O2 and that remove metabolic waste products, on one side; and the demands of the tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84524520cf71adce0024c026e0605be5
https://mts.intechopen.com/articles/show/title/role-of-the-il-6-jak-stat-pathway-in-tumor-angiogenesis-influence-of-estrogen-status
https://mts.intechopen.com/articles/show/title/role-of-the-il-6-jak-stat-pathway-in-tumor-angiogenesis-influence-of-estrogen-status
Autor:
Haidée Aranda-Tavío, Carlota Recio, Leandro Fernández-Pérez, Miguel Guerra-Rodríguez, Borja Guerra, Yeray Brito-Casillas, Patricia Martín-Rodríguez, José Manuel García-Castellano, Mercedes de Mirecki-Garrido, Ana Estévez-Braun
Publikováno v:
Oncogene. 38:4657-4668
The signal transducer and activator of transcription (STAT) are transcription factors that work via JAK/STAT pathway regulating the expression of genes involved in cell survival, proliferation, differentiation, development, immune response, and, amon
Autor:
María Claudia Sandoval-Usme, Adriana Umaña-Pérez, Borja Guerra, Octavio Hernández-Perera, José Manuel García-Castellano, Leandro Fernández-Pérez, Myriam Sánchez-Gómez
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87769 (2014)
Recent studies have demonstrated that statins reduce cell viability and induce apoptosis in various types of cancer cells. The molecular mechanisms underlying these effects are poorly understood. The JAK/STAT pathway plays an important role in the re
Externí odkaz:
https://doaj.org/article/5410fff205ed4ae49b8b2a260a81a9cf
Autor:
Miguel Guerra-Rodríguez, Carlota Recio, Haidée Aranda-Tavío, Leandro Fernández-Pérez, José Manuel García-Castellano, Borja Guerra
Publikováno v:
Frontiers in Oncology
Frontiers in Oncology, Vol 11 (2021)
Frontiers in Oncology, Vol 11 (2021)
A hallmark of cancer cells includes a metabolic reprograming that provides energy, the essential building blocks, and signaling required to maintain survival, rapid growth, metastasis, and drug resistance of many cancers. The influence of tumor micro
Autor:
Rubén P. Machín, Ana López-García, Leandro Fernández-Pérez, Yanira Brito, José A. Ruíz-Caballero, Juan C. Rodríguez-Bermejo, Pedro Llontop, Bernardino Clavo, José Manuel García-Castellano, Miguel A. Ponce-González, María D. Fiuza, Norberto Santana-Rodríguez, Jesús Villar, Ricardo García-Herrera
Publikováno v:
The Journal of Heart and Lung Transplantation. 31:213-221
Background Chronic rejection (CR) is the main reason for the limited survival rates among lung transplant (LT) recipients. There remains no effective treatment for CR. The aim of this study was to identify new molecular mechanisms involved in CR by u
Autor:
José Manuel García-Castellano, Rubén Pérez-Machín, Aaron Hernandez-Santana, Jose María Zubeldia, Verónica Pérez-López, Miguel Jiménez-del-Rio
Publikováno v:
Chinese Medicine. :215-222
Ajuga Turkestanica, an herbaceous flowering species in the mint family, has been traditionally used in Turkeyand Uzbekistan for heart disease, muscle aches and stomach problems. Due to its high levels of phytoecdysteroids (particularly the characteri
Autor:
Bernardino Clavo, José Manuel García Castellano, Juan Carlos Rodríguez Bermejo, Pedro Llontop Santisteban, Yanira Brito Godoy, Miguel Ángel Ponce González, Andrés Varela de Ugarte, Norberto Santana Rodríguez, José Antonio Ruiz Caballero, Ricardo García Herrera, Keila Zerecero, Ana López García
Publikováno v:
Archivos de Bronconeumología. 47:488-494
Resumen Introduccion El trasplante microquirurgico de pulmon en ratas ha permitido adquirir nuevos conocimientos sobre el trasplante de pulmon. Sin embargo, algunos aspectos de la tecnica de trasplante en humanos aun no han sido incluidos en este mod
Autor:
Nagib Atallah Yordi, Yanira Brito, Miguel A. Ponce, Norberto Santana-Rodríguez, Bernardino Clavo, José Manuel García-Castellano, Ricardo Chirino, María D. Fiuza, Pedro Llontop, Ricardo García-Herrera, Rubén P. Machín, Ana López
Publikováno v:
Lung. 189:251-255
Ischemia-reperfusion injury (IRI) is a common complication after lung transplantation. There is evidence that reactive oxygen species are involved in its pathogenesis. We designed an experimental study to evaluate whether the administration of antiox
Autor:
Estefanía Herrera-Ramos, José Gonçalo-Marques, Ana Cordeiro, María Cárdenes, José Luis Pérez-Arellano, Mónica Valerón-Lemaur, Katia Abarca, José Luerez Arellano Bustamante, Laurent Abel, Adela Francés, Elena Colino, Paweł Remiszewski, Stéphanie Boisson-Dupuis, Jacqueline Feinberg, Esther Santiago, Stéphane Blanche, Carmen Navarrete, Xiao-Fei Kong, Capucine Picard, José Pestano, M. Isabel García-Laorden, Alexandra F. Freeman, Jose Antonio Caminero, Steven M. Holland, Quentin B. Vincent, Jean-Laurent Casanova, Lucile Janniere, José Manuel García-Castellano, Luisa Silveira, Leandro Fernández-Pérez, Emília Faria, Ithaisa Sologuren, Carlos Rodríguez-Gallego, Ariane Chapgier
Publikováno v:
Human Molecular Genetics. 20:1509-1523
We report a series of 14 patients from 11 kindreds with recessive partial (RP)-interferon (IFN)-γR1 deficiency. The I87T mutation was found in nine homozygous patients from Chile, Portugal and Poland, and the V63G mutation was found in five homozygo
Autor:
Mercedes Campillo, Raquel G. Díaz-Peńate, Elisa Pérez-Sacau, José Manuel García-Castellano, Angel G. Ravelo, Leonardo Pardo, Ana Estévez-Braun
Publikováno v:
Journal of Medicinal Chemistry. 50:696-706
Catalyst/HypoGen pharmacophore modeling approach and three-dimensional quantitative structure-activity relationship (3D-QSAR)/comparative molecular similarity indices analysis (CoMSIA) methods have been successfully applied to explain the cytotoxic a