Zobrazeno 1 - 10
of 51
pro vyhledávání: '"José M. de Pereda"'
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-22 (2023)
Abstract Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyr
Externí odkaz:
https://doaj.org/article/69835b309c8c4fcc8550fc5ffc4c0d4f
Autor:
José A. Manso, Arturo Carabias, Zsuzsa Sárkány, José M. de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT An important feature associated with Candida albicans pathogenicity is its ability to switch between yeast and hyphal forms, a process in which CaRas1 plays a key role. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCd
Externí odkaz:
https://doaj.org/article/91a4ad11f5194a0d9e9376efb1dace40
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 1 (2021)
Abnormally increased signaling by the GTPase RAP1 favors progression of diverse tumors. We have characterized the auto-regulation and activation of C3G (RAPGEF1), an activator of RAP1. This led us to discover mutations in non-Hodgkin’s lymphomas th
Externí odkaz:
https://doaj.org/article/2a1d97d348ea4780a29080c5f459a938
Autor:
Antonio Rodríguez-Blázquez, Arturo Carabias, Alba Morán-Vaquero, Sergio de Cima, Juan R. Luque-Ortega, Carlos Alfonso, Peter Schuck, José Antonio Manso, Sandra Macedo-Ribeiro, Carmen Guerrero, José M. de Pereda
Publikováno v:
Rodríguez-Blázquez, A, Carabias, A, Morán-Vaquero, A, de Cima, S, Luque-Ortega, J R, Alfonso, C, Schuck, P, Manso, J A, Macedo-Ribeiro, S, Guerrero, C & de Pereda, J M 2023, ' Crk proteins activate the Rap1 guanine nucleotide exchange factor C3G by segregated adaptor-dependent and-independent mechanisms ', Cell Communication and Signaling, vol. 21, 30 . https://doi.org/10.1186/s12964-023-01042-2
Background C3G is a guanine nucleotide exchange factor (GEF) that activates Rap1 to promote cell adhesion. Resting C3G is autoinhibited and the GEF activity is released by stimuli that signal through tyrosine kinases. C3G is activated by tyrosine pho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd197d03a68cc847d778fd7df149efdc
https://doi.org/10.1101/2022.11.24.515150
https://doi.org/10.1101/2022.11.24.515150
Autor:
José A Manso, Arturo Carabias, Zsuzsa Sárkány, José M de Pereda, Pedro José Barbosa Pereira, Sandra Macedo-Ribeiro
Ras-like protein 1 (CaRas1) is a key regulator of the switch between the yeast and hyphal forms of Candida albicans, a feature associated with pathogenesis. CaRas1 is activated by the guanine nucleotide exchange factor (GEF) CaCdc25, triggering hypha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66bc09a8807f663e34bd72332f6ef4d2
https://doi.org/10.1101/2022.08.23.504951
https://doi.org/10.1101/2022.08.23.504951
Autor:
José A. Manso, Tamara Marcos, Virginia Ruiz-Martín, Javier Casas, Pablo Alcón, Mariano Sánchez Crespo, Yolanda Bayón, José M. de Pereda, Andrés Alonso
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
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Mutations in the adaptor protein PSTPIP1 cause a spectrum of autoinflammatory diseases, including PAPA and PAMI; however, the mechanism underlying these diseases remains unknown. Most of these mutations lie in PSTPIP1 F-BAR domain, which binds to LYP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572747db1f1eb632d28756392d5bc6ed
http://hdl.handle.net/10261/282511
http://hdl.handle.net/10261/282511
Autor:
José M. de Pereda, Arnoud Sonnenberg, Lisa te Molder, Kevin Wilhelmsen, Niels Heemskerk, Joyce Schuring, Maaike Kreft
Publikováno v:
Scientific Reports, 11(1):8675. Nature Publishing Group
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
te Molder, L, Kreft, M, Heemskerk, N, Schuring, J, de Pereda, J M, Wilhelmsen, K & Sonnenberg, A 2021, ' EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines ', Scientific Reports, vol. 11, no. 1, 8675, pp. 8675 . https://doi.org/10.1038/s41598-021-88134-6
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Scientific Reports
te Molder, L, Kreft, M, Heemskerk, N, Schuring, J, de Pereda, J M, Wilhelmsen, K & Sonnenberg, A 2021, ' EGFR-dependent tyrosine phosphorylation of integrin β4 is not required for downstream signaling events in cancer cell lines ', Scientific Reports, vol. 11, no. 1, 8675, pp. 8675 . https://doi.org/10.1038/s41598-021-88134-6
© The Author(s) 2021.
In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and
In epithelial cancers, the epidermal growth factor receptor (EGFR) and integrin α6β4 are frequently overexpressed and found to synergistically activate intracellular signaling pathways that promote cell proliferation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::570c9a1b0856b2178bee42e37c15eac7
https://research.vumc.nl/en/publications/d95793b7-e664-4752-8851-ba331fd43120
https://research.vumc.nl/en/publications/d95793b7-e664-4752-8851-ba331fd43120
Publikováno v:
Journal of cell science. 134(18)
Hemidesmosomes (HDs) are specialized multiprotein complexes that connect the keratin cytoskeleton of epithelial cells to the extracellular matrix (ECM). In the skin, these complexes provide stable adhesion of basal keratinocytes to the underlying bas
Autor:
Dolores E. López, José M. de Pereda, Ricardo Gómez-Nieto, Elena Díaz-Casado, María Jara-Acevedo, Luis J. Muñoz
Publikováno v:
PLoS ONE, Vol 15, Iss 4, p e0231603 (2020)
Digital.CSIC. Repositorio Institucional del CSIC
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Digital.CSIC. Repositorio Institucional del CSIC
instname
© 2020 Díaz-Casado et al.
In the funding statement, the grant number from the funder Spanish JCyL cofinanced with the European Union FEDER funds 2017 is listed incorrectly. The correct grant number is: SA070P17.
In the funding statement, the grant number from the funder Spanish JCyL cofinanced with the European Union FEDER funds 2017 is listed incorrectly. The correct grant number is: SA070P17.
Autor:
Patricia González-Sáenz, Carmen Guerrero, Sergio de Cima, Arturo Carabias, Alba Morán-Vaquero, José M. de Pereda, María Teresa Gómez-Hernández, Antonio Rodríguez-Blázquez
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
C3G is a guanine nucleotide exchange factor (GEF) that regulates cell adhesion and migration by activating the GTPase Rap1. The GEF activity of C3G is stimulated by the adaptor proteins Crk and CrkL and by tyrosine phosphorylation. Here, we uncovered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a54a246e722bf348910088dbd97e64
http://hdl.handle.net/10261/222928
http://hdl.handle.net/10261/222928