Zobrazeno 1 - 10
of 34
pro vyhledávání: '"José M. Sala-Trepat"'
Autor:
Miguel Calvo, Javier Naval, Jorge Laborda, José M. Sala-Trepat, José Uriel, Monique Frain, Pierre Dubouch
Publikováno v:
The Journal of Biochemistry. 111:649-654
alpha-Fetoprotein and albumin, two members of a multigene family, reversibly bind fatty acids with high affinity. The origin of alpha-fetoprotein (AFP) and albumin present in fetal tissues other than the liver and yolk sac is a subject of controversy
Publikováno v:
Europe PubMed Central
Scopus-Elsevier
Scopus-Elsevier
A segment of 1,022 base pairs (bp) of the 5'-flanking region of the human albumin gene, fused to a reporter gene, directs hepatoma-specific transcription. Three functionally distinct regions have been defined by deletion analysis: (i) a negative elem
Publikováno v:
Cell Biology International Reports. 9:31-42
Immunoperoxidase techniques have yielded conflicting results concerning the percentage of hepatocytes engaged in albumin production in normal adult rats. In addition, the question of whether functional differences in the synthesis of plasma proteins
Publikováno v:
Human Genetics. 67:48-51
Hybridization of albumin clones cDNA with human DNAs digested by several restriction endonucleases reveals two HaeIII polymorphisms. The first polymorphism, H1, is of low frequency (f1 = 0.05); the second, which is validated by family analysis, occur
Autor:
James Bonner, R. Bruce Wallace, Antonio A. Reyes, Thomas D. Sargent, Jung-Rung Wu, José M. Sala-Trepat
Publikováno v:
Proceedings of the National Academy of Sciences. 76:3256-3260
The rat serum albumin gene has been isolated from a recombinant library containing the entire rat genome cloned in the lambda phage Charon 4A. Preliminary R-loop and restriction analysis has revealed that this gene is split into at least 14 fragments
Publikováno v:
Human Heredity. 35:394-398
Hybridization of alpha-fetoprotein clones cDNA with human DNAs digested by seven restriction endonucleases reveals one polymorphism. This polymorphism, detected after restriction by MspI, is at low frequency (f = 0.02) and is validated by family anal
Publikováno v:
Proceedings of the National Academy of Sciences. 81:5031-5035
We have examined the DNase I sensitivity of the albumin and alpha-fetoprotein (AFP) genes in different rat tissues (adult liver and kidney) and cloned cell lines (hepatoma 7777-C8, JF1 fibroblasts), which show drastic differences in the level of expr
Autor:
Edit Hermesz, Tamas Erdos, Maryse Poiret, Aniko Venetianer, Anne Poliard, José M. Sala-Trepat
Publikováno v:
Differentiation. 32:148-156
The Faza 967 ‘differentiated', dexamethasone (DEX)-sensitive cell line of Reuber rat hepatoma cells does not synthesize detectable amounts of alpha-fetoprotein (AFP), whereas it does produce albumin. AFP production was activated in ‘differentiate
Publikováno v:
Biochemical Genetics. 23:257-266
Two types of variant EcoRI restriction enzyme patterns of albumin-gene DNA fragments are found in different inbred strains of rats and reflect allelic polymorphism. The structural basis of the two allelic forms has been analyzed by mapping the EcoRI
Publikováno v:
Proceedings of the National Academy of Sciences. 84:2135-2139
We have examined the chromatin structure of the 5'-flanking region of the albumin and alpha-fetoprotein (Afp) genes in different developing rat tissues and cloned cell lines that display various functional states of these genes. Nuclease-hypersensiti