Zobrazeno 1 - 10
of 10
pro vyhledávání: '"José M. Moreno‐Navarrete"'
Autor:
Aina Lluch, Jessica Latorre, Angela Serena-Maione, Isabel Espadas, Estefanía Caballano-Infantes, José M. Moreno-Navarrete, Núria Oliveras-Cañellas, Wifredo Ricart, María M. Malagón, Alejandro Martin-Montalvo, Walter Birchmeier, Witold Szymanski, Johannes Graumann, María Gómez-Serrano, Elena Sommariva, José M. Fernández-Real, Francisco J. Ortega
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Plakophilin-2 (PKP2) is a key component of desmosomes, which, when defective, is known to promote the fibro-fatty infiltration of heart muscle. Less attention has been given to its role in adipose tissue. We report here that levels of PKP2 s
Externí odkaz:
https://doaj.org/article/c9aab534331a4f3fa90b32b90c48e65f
Autor:
Aina Lluch, Sonia R. Veiga, Jèssica Latorre, José M. Moreno-Navarrete, Núria Bonifaci, Van Dien Nguyen, You Zhou, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, David Llobet-Navas, George Thomas, Ruth Rodríguez-Barrueco, José M. Fernández-Real, Sara C. Kozma, Francisco J. Ortega
Publikováno v:
JCI Insight, Vol 7, Iss 14 (2022)
The ribosomal protein S6 kinase 1 (S6K1) is a relevant effector downstream of the mammalian target of rapamycin complex 1 (mTORC1), best known for its role in the control of lipid homeostasis. Consistent with this, mice lacking the S6k1 gene have a d
Externí odkaz:
https://doaj.org/article/fd58ace89a53441583d2cf1df43a3a08
A microRNA Cluster Controls Fat Cell Differentiation and Adipose Tissue Expansion By Regulating SNCG
Autor:
Ruth Rodríguez‐Barrueco, Jessica Latorre, Laura Devis‐Jáuregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll‐Iglesias, Katja Gassner, Meredith L. Davis, José M. Moreno‐Navarrete, Anna Castells‐Nobau, Laura Plata‐Peña, Miki Dalmau‐Pastor, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga‐Rodríguez, Wifredo Ricart, José M. Fernández‐Real, José M. Silva, Francisco J. Ortega, David Llobet‐Navas
Publikováno v:
Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Abstract The H19X‐encoded miR‐424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity
Externí odkaz:
https://doaj.org/article/e3f63b7bc662455caa34ba1b1fa999a2
Autor:
Jèssica Latorre, José M. Moreno-Navarrete, Mónica Sabater, Maria Buxo, José I. Rodriguez-Hermosa, Jordi Girones, José M. Fort, Ramón Vilallonga, Wifredo Ricart, Rafael Simo, Jose-Manuel Fernandez-Real, Francisco J. Ortega
Publikováno v:
Cellular Physiology and Biochemistry, Vol 51, Iss 3, Pp 1051-1068 (2018)
Background/Aims: Obesity is characterized by the immune activation that eventually dampens insulin sensitivity and changes metabolism. This study explores the impact of different inflammatory/ anti-inflammatory paradigms on the expression of toll-lik
Externí odkaz:
https://doaj.org/article/2ca5ca824dce4d28a45d9c2218436586
Autor:
Jèssica Latorre, Francisco J. Ortega, Laura Liñares-Pose, José M. Moreno-Navarrete, Aina Lluch, Ferran Comas, Núria Oliveras-Cañellas, Wifredo Ricart, Marcus Höring, You Zhou, Gerhard Liebisch, P.A. Nidhina Haridas, Vesa M. Olkkonen, Miguel López, José M. Fernández-Real
Publikováno v:
EBioMedicine, Vol 53, Iss , Pp - (2020)
Background: While the impact of metformin in hepatocytes leads to fatty acid (FA) oxidation and decreased lipogenesis, hepatic microRNAs (miRNAs) have been associated with fat overload and impaired metabolism, contributing to the pathogenesis of non-
Externí odkaz:
https://doaj.org/article/6aa13ae9f1304a82a59ada019901c3cd
A microRNA cluster controls fat cell differentiation and adipose tissue expansion by regulating SNCG
Autor:
Ruth Rodríguez‐Barrueco, Jessica Latorre, Laura Devis‐Jáuregui, Aina Lluch, Nuria Bonifaci, Francisco J. Llobet, Mireia Olivan, Laura Coll‐Iglesias, Katja Gassner, Meredith L. Davis, José M. Moreno‐Navarrete, Anna Castells‐Nobau, Laura Plata‐Peña, Miki Dalmau‐Pastor, Marcus Höring, Gerhard Liebisch, Vesa M. Olkkonen, Maria Arnoriaga‐Rodríguez, Wifredo Ricart, José M. Fernández‐Real, José M. Silva, Francisco J. Ortega, David Llobet‐Navas
Publikováno v:
Advanced Science, Vol 9, Iss 4, Pp n/a-n/a (2022)
Dipòsit Digital de la UB
Universidad de Barcelona
Dipòsit Digital de la UB
Universidad de Barcelona
The H19X-encoded miR-424(322)/503 cluster regulates multiple cellular functions. Here, it is reported for the first time that it is also a critical linchpin of fat mass expansion. Deletion of this miRNA cluster in mice results in obesity, while incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd31ca7603b3f84c28bd2b992ec8e2bb
http://hdl.handle.net/2445/189979
http://hdl.handle.net/2445/189979
Autor:
Francisco J, Ortega, Josep M, Mercader, José M, Moreno-Navarrete, Mónica, Sabater, Neus, Pueyo, Sergio, Valdés, Bartomeu, Ruiz, Elodie, Luche, Matteo, Serino, Deborah, Naon, Wifredo, Ricart, Patricia, Botas, Elias, Delgado, Remy, Burcelin, Gema, Frühbeck, Fatima, Bosch, Gertrude, Mingrone, Antonio, Zorzano, José M, Fernández-Real
Publikováno v:
Journal of Molecular Medicine. 91:523-534
Calgranulin B (S100A9) was recognized as a candidate type 2 diabetes (T2D) gene in the genomic profiling of muscle from a rodent model of T2D and identifying the human orthologs of genes localized in T2D susceptibility regions. Circulating and S100A9
Autor:
Neus Pueyo, Francisco J Ortega, Josep M Mercader, José M Moreno-Navarrete, Monica Sabater, Sílvia Bonàs, Patricia Botas, Elías Delgado, Wifredo Ricart, María T Martinez-Larrad, Manuel Serrano-Ríos, David Torrents, José M Fernández-Real
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60468 (2013)
CONTEXT: Surfactant protein-D (SP-D) is a primordial component of the innate immune system intrinsically linked to metabolic pathways. We aimed to study the association of single nucleotide polymorphisms (SNPs) affecting SP-D with insulin resistance
Externí odkaz:
https://doaj.org/article/d31ba94b88b8407b85acaccc9d1e4da4
Autor:
Francisco J Ortega, José M Moreno-Navarrete, Dolores Mayas, Eva García-Santos, María Gómez-Serrano, José I Rodriguez-Hermosa, Bartomeu Ruiz, Wifredo Ricart, Francisco J Tinahones, Gema Frühbeck, Belen Peral, José M Fernández-Real
Publikováno v:
PLoS ONE, Vol 7, Iss 5, p e33233 (2012)
CONTEXT: Expression and activity of the main lipogenic enzymes is paradoxically decreased in obesity, but the mechanisms behind these findings are poorly known. Breast Cancer 1 (BrCa1) interacts with acetyl-CoA carboxylase (ACC) reducing the rate of
Externí odkaz:
https://doaj.org/article/7ba185e10c294f73b2e20f897c901e65
Autor:
Francisco J Ortega, José M Moreno-Navarrete, Gerard Pardo, Monica Sabater, Manuela Hummel, Anna Ferrer, Jose I Rodriguez-Hermosa, Bartomeu Ruiz, Wifredo Ricart, Belen Peral, José M Fernández-Real
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9022 (2010)
BACKGROUND: Potential regulators of adipogenesis include microRNAs (miRNAs), small non-coding RNAs that have been recently shown related to adiposity and differentially expressed in fat depots. However, to date no study is available, to our knowledge
Externí odkaz:
https://doaj.org/article/aadbce41ca69404a9350768d4aed311a