Zobrazeno 1 - 10
of 34
pro vyhledávání: '"José M. Martinez-Navio"'
Autor:
Matthew R. Gardner, Desiree E. Mendes, Claudia P. Muniz, José M. Martinez-Navio, Sebastian P. Fuchs, Guangping Gao, Ronald C. Desrosiers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 199-206 (2022)
Prescreening of participants in clinical trials that use adeno-associated virus (AAV) vectors is required to identify naive participants, as preexisting neutralizing antibodies can limit the efficacy of AAV gene therapies. The presence of antibodies
Externí odkaz:
https://doaj.org/article/49da5379fc3d46bda706e8a9489bcbc3
Autor:
James M. Termini, José M. Martinez-Navio, Guangping Gao, Sebastian P. Fuchs, Ronald C. Desrosiers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 204-217 (2021)
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the us
Externí odkaz:
https://doaj.org/article/374014c5546c4147b35ded0614fa653e
Autor:
Nuria Pedreño-Lopez, Christine M. Dang, Brandon C. Rosen, Michael J. Ricciardi, Varian K. Bailey, Martin J. Gutman, Lucas Gonzalez-Nieto, Matthias G. Pauthner, Khoa Le, Ge Song, Raiees Andrabi, Kim L. Weisgrau, Nicholas Pomplun, José M. Martinez-Navio, Sebastian P. Fuchs, Jens Wrammert, Eva G. Rakasz, Jeffrey D. Lifson, Mauricio A. Martins, Dennis R. Burton, David I. Watkins, Diogo M. Magnani
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 225-237 (2020)
Structural characterization of the HIV-1 Envelope (Env) glycoprotein has facilitated the development of Env probes to isolate HIV-specific monoclonal antibodies (mAbs). However, preclinical studies have largely evaluated these virus-specific mAbs aga
Externí odkaz:
https://doaj.org/article/583e2f5e1bdc4c94b11792ddc7103b3a
Autor:
Sebastian P. Fuchs, José M. Martinez-Navio, Eva G. Rakasz, Guangping Gao, Ronald C. Desrosiers
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss , Pp 94-102 (2020)
A number of publications have described the use of adeno-associated virus (AAV) for the delivery of anti-HIV and anti-simian immunodeficiency virus (SIV) monoclonal antibodies (mAbs) to rhesus monkeys. Anti-drug antibodies (ADAs) have been frequently
Externí odkaz:
https://doaj.org/article/3970fe89b2a04b72b37ac27be8e57d9a
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://doaj.org/article/0e0333f1ddf1421f80c4e6c8d8b1c964
Autor:
José M. Martinez-Navio, Sebastian P. Fuchs, Desiree E. Mendes, Eva G. Rakasz, Guangping Gao, Jeffrey D. Lifson, Ronald C. Desrosiers
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Long-term delivery of anti-HIV monoclonal antibodies using adeno-associated virus (AAV) holds promise for the prevention and treatment of HIV infection. We previously reported that after receiving a single administration of AAV vector coding for anti
Externí odkaz:
https://doaj.org/article/1cc0d8d6dd8047878b413381c5dcc63f
Autor:
Sebastian P. Fuchs, Guangping Gao, James M. Termini, Ronald C. Desrosiers, José M. Martinez-Navio
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss, Pp 204-217 (2021)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
The absence of fucose on asparagine-297 of the human immunoglobulin G (IgG) heavy chain has been shown to enhance antibody-dependent cellular cytotoxicity (ADCC) activity by 10- to 100-fold compared to fucosylated antibody. Our lab is studying the us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa44ade5efbd4e54b91ee5fd852d403e
http://www.sciencedirect.com/science/article/pii/S232905012030228X
http://www.sciencedirect.com/science/article/pii/S232905012030228X
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0158009 (2016)
Adeno-associated virus (AAV) has become a vector of choice for the treatment of a variety of genetic diseases that require safe and long-term delivery of a missing protein. Muscle-directed gene transfer for delivery of protective antibodies against A
Externí odkaz:
https://doaj.org/article/c9770ef8c536441e9b1551e9bba2d73f
Autor:
Jeffrey D. Lifson, Eva G. Rakasz, Brandon C. Rosen, Khoa Le, Mauricio A. Martins, Lucas Gonzalez-Nieto, Raiees Andrabi, Michael J. Ricciardi, Nicholas Pomplun, Martin J. Gutman, José M. Martinez-Navio, Sebastian P. Fuchs, Varian K. Bailey, Christine M. Dang, David I. Watkins, Kim L. Weisgrau, Ge Song, Diogo M. Magnani, Matthias Pauthner, Jens Wrammert, Dennis R. Burton, Nuria Pedreño-Lopez
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 16, Iss, Pp 225-237 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Structural characterization of the HIV-1 Envelope (Env) glycoprotein has facilitated the development of Env probes to isolate HIV-specific monoclonal antibodies (mAbs). However, preclinical studies have largely evaluated these virus-specific mAbs aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f617dce13c1a61ed593cb959456584c
https://doi.org/10.1016/j.omtm.2020.01.010
https://doi.org/10.1016/j.omtm.2020.01.010
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, Vol 12 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47c75dab890b5670c15fae3a25409d2d
http://europepmc.org/articles/PMC8724200
http://europepmc.org/articles/PMC8724200