Výsledky vyhledávání - "José M. La Fuente"

Akademický článek

LDL-c/HDL-c Ratio and NADPH-Oxidase-2-Derived Oxidative Stress as Main Determinants of Microvascular Endothelial Function in Morbidly Obese Subjects

Autor: Jorge Santos, José M. La Fuente, Argentina Fernández, Paula Ruano, Javier Angulo

Publikováno v: Antioxidants, Vol 13, Iss 9, p 1139 (2024)

The identification of obese subjects at higher risk for cardiovascular disease (CVD) is required. We aimed to characterize determinants of endothelial dysfunction, the initial step to CVD, in small omental arteries of visceral fat from obese subjects

Externí odkaz: https://doaj.org/article/6c72872aa3cf4901a395bcb89ff0e0c6

Zobrazit plný text záznamu

Akademický článek

Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention

Autor: Javier Angulo, Mariam El Assar, Alejandro Sevilleja-Ortiz, Argentina Fernández, Alberto Sánchez-Ferrer, Javier Romero-Otero, Juan I. Martínez-Salamanca, José M. La Fuente, Leocadio Rodríguez-Mañas

Publikováno v: Redox Biology, Vol 26, Iss , Pp - (2019)

Oxidative stress contributes to endothelial dysfunction, a key step in cardiovascular disease development. Ageing-related vascular dysfunction involves defective antioxidant response. Nuclear factor erythroid 2-like-2 (Nrf2), orchestrates cellular re

Externí odkaz: https://doaj.org/article/d1ba8369e2f747f6be898f70ad3bca49

Zobrazit plný text záznamu

STIM/Orai Inhibition as a Strategy for Alleviating Diabetic Erectile Dysfunction Through Modulation of Rat and Human Penile Tissue Contractility and in vivo Potentiation of Erectile Responses

Autor: Alejandro Sevilleja-Ortiz, Mariam El Assar, Borja García-Gómez, José M. La Fuente, Manuel Alonso-Isa, Javier Romero-Otero, Juan I. Martínez-Salamanca, Argentina Fernández, Leocadio Rodríguez-Mañas, Javier Angulo

Publikováno v: The Journal of Sexual Medicine. 19:1733-1749

Background Stromal interaction molecule (STIM)/Orai calcium entry system appears to have a role in erectile dysfunction (ED) pathophysiology but its specific contribution to diabetic ED was not elucidated. Aim To evaluate STIM/Orai inhibition on func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cdfa023710d0529f74f3ecc868648ca
https://doi.org/10.1016/j.jsxm.2022.08.200

Zobrazit plný text záznamu

Enhanced Contribution of Orai Channels to Contractility of Human Penile Smooth Muscle in Erectile Dysfunction

Autor: José M. La Fuente, Javier Angulo, E. García-Rojo, Borja García-Gómez, José Medina-Polo, Mariam El Assar, Argentina Fernández, Leocadio Rodríguez-Mañas, Alejandro Sevilleja-Ortiz, Javier Romero-Otero

Publikováno v: The Journal of Sexual Medicine. 17:881-891

Background Store-operated calcium entry and its key players, stromal interaction molecule (STIM) and Orai calcium channels, have been proposed as emergent therapeutic targets in cardiovascular pathophysiology. We hypothesize alteration of STIM/Orai s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd54f786e4deef325dab8af71c77976e
https://doi.org/10.1016/j.jsxm.2020.02.020

Zobrazit plný text záznamu

Ageing-induced hypercontractility is related to functional enhancement of STIM/Orai and upregulation of Orai 3 in rat and human penile tissue

Autor: José M. La Fuente, Alberto Sánchez-Ferrer, Leocadio Rodríguez-Mañas, Borja García-Gómez, Argentina Fernández, Mariam El Assar, E. García-Rojo, Alejandro Sevilleja-Ortiz, Javier Romero-Otero, Javier C. Angulo

Publikováno v: Mechanisms of ageing and development. 200

The role of STIM/Orai calcium entry system on vascular ageing has not been elucidated. We aimed to evaluate the influence of ageing on STIM/Orai signalling and its role on ageing-induced alterations of contractile function in rat corpus cavernosum (R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d78aa49c36255c88ed8a3e27eb97ccd2
https://pubmed.ncbi.nlm.nih.gov/34699858

Zobrazit plný text záznamu

MP84-09 DEFECTIVE L-CYSTEINE/HYDROGEN SULFIDE PATHWAY IN HUMAN CORPUS CAVERNOSUM AND PENILE ARTERIES FROM MEN WITH ERECTILE DYSFUNCTION

Autor: Alejandro Sevilleja-Ortiz, José M. La Fuente, Juan Ignacio Martínez-Salamanca, Javier C. Angulo, Joaquín Carballido, Esaú Fernández-Pascual

Publikováno v: Journal of Urology. 203

INTRODUCTION AND OBJECTIVE:Hydrogen sulfide (H2S) signaling has been proposed to participate in erectile physiology. L-cysteine (CYS)/H2S pathway stimulation causes cGMP-dependent relaxation of hum...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2bb758b82c57145a8a8ca11b62836b9
https://doi.org/10.1097/ju.0000000000000976.09

Zobrazit plný text záznamu

Short-term pharmacological activation of Nrf2 ameliorates vascular dysfunction in aged rats and in pathological human vasculature. A potential target for therapeutic intervention

Autor: Argentina Fernández, José M. La Fuente, Alberto Sánchez-Ferrer, Javier Angulo, Leocadio Rodríguez-Mañas, Alejandro Sevilleja-Ortiz, Juan Ignacio Martínez-Salamanca, Javier Romero-Otero, Mariam El Assar

Publikováno v: Redox Biology, Vol 26, Iss, Pp-(2019)
Redox Biology

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f0c366c2a741e5c8f8c2b0cdea731b
http://www.sciencedirect.com/science/article/pii/S2213231719305488

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání