Zobrazeno 1 - 10
of 18
pro vyhledávání: '"José M. Jiménez-López"'
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1859:1657-1667
Alkylphospholipids (APLs) represent a new class of drugs which do not interact directly with DNA but act on the cell membrane where they accumulate and interfere with lipid metabolism and signalling pathways. This review summarizes the mode of action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36674aa8aa58175584fed1ca9892ca4c
https://doi.org/10.1016/j.bbamem.2017.02.016
https://doi.org/10.1016/j.bbamem.2017.02.016
Publikováno v:
Biochemical Pharmacology. 96:10-19
Perifosine exerts an antiproliferative effect on HepG2 and U-87 MG cells and also interferes with the transport of cholesterol from the plasma membrane to the endoplasmic reticulum (ER). Recently we demonstrated that exposure of U-87 MG cells to peri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f0362673e6e0bcf86b2df24bf2819d
https://doi.org/10.1016/j.bcp.2015.04.015
https://doi.org/10.1016/j.bcp.2015.04.015
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 14:545-558
Alkylphospholipid (APL) analogues are promising candidates in the search for treatments for cancer. In contrast to standard chemotherapeutic drugs, these lipophilic agents target the cell membrane without interacting directly with DNA. A variety of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e73e2270032ff622dd496bafe072f2
https://doi.org/10.2174/1871520614666140309224707
https://doi.org/10.2174/1871520614666140309224707
Publikováno v:
British Journal of Pharmacology. 160:355-366
Background and purpose: Alkylphospholipid (APL) analogues constitute a new class of synthetic anti-tumour agents that act directly on cell membranes. We have previously demonstrated that hexadecylphosphocholine (HePC) alters intracellular cholesterol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::96815f21da2d9abeef2501373ce2ea4b
https://doi.org/10.1111/j.1476-5381.2010.00689.x
https://doi.org/10.1111/j.1476-5381.2010.00689.x
Publikováno v:
FEBS Journal. 275:1675-1686
We have shown, in a previous publication, that nontoxic concentrations of hexadecylphosphocholine exert an antiproliferative effect on HepG2 cells. Hexadecylphosphocholine also interferes with the biosynthesis of cholesterol and phosphatidylcholine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d4bef8206b3e6b4bbcacdcfbd9a8657a
https://doi.org/10.1111/j.1742-4658.2008.06322.x
https://doi.org/10.1111/j.1742-4658.2008.06322.x
Publikováno v:
Neurochemistry International. 50:858-865
We have analyzed the effects of ethanol in vitro on the remodeling of neutral lipids and phospholipids in mitochondria and microsomes isolated from chick brain. We used three different fatty acyl-CoAs of similar chain lengths but different degrees of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b820b8ed394d4d5b7c23144fe256ffbc
https://doi.org/10.1016/j.neuint.2007.02.007
https://doi.org/10.1016/j.neuint.2007.02.007
Publikováno v:
Experimental cell research. 340(1)
Background Alkylphospholipid (APL) analogs are a new class of membrane-directed synthetic compounds with a variety of biological actions and clinical applications. In particular, these agents are promising candidates in cancer treatment. We have demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e5b12315810ae29b07b73733b92c3f2
https://pubmed.ncbi.nlm.nih.gov/26712518
https://pubmed.ncbi.nlm.nih.gov/26712518
Publikováno v:
The International Journal of Biochemistry & Cell Biology. 36:153-161
We reported in a recent publication that hexadecylphosphocholine (HePC), a lysophospholipid analogue, reduces cell proliferation in HepG2 cells and at the same time inhibits the biosynthesis of phosphatidylcholine (PC) via CDP-choline by acting upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb26347b840b1249f7c94c3d0de908bb
https://doi.org/10.1016/s1357-2725(03)00193-6
https://doi.org/10.1016/s1357-2725(03)00193-6
Publikováno v:
European Journal of Biochemistry. 269:4649-4655
Hexadecylphosphocholine (HePC) is a synthetic lipid representative of a new group of antiproliferative agents, alkylphosphocholines (APC), which are promising candidates in anticancer therapy. Thus we have studied the action of HePC on the human hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31a600244731a81909b621336f49e94e
https://doi.org/10.1046/j.1432-1033.2002.03169.x
https://doi.org/10.1046/j.1432-1033.2002.03169.x
Publikováno v:
Biochemical Pharmacology. 63:1485-1490
The influence of both short- and long-term ethanol exposure on the lipid metabolism was determined in the human hepatoma cell line HepG2. Ethanol did not cause any cytotoxicity or lipid peroxidation even after 7 days of 100 mM ethanol treatment of He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283882242948720709ff526d6cd1d0d6
https://doi.org/10.1016/s0006-2952(02)00896-1
https://doi.org/10.1016/s0006-2952(02)00896-1