Výsledky vyhledávání - "José M. Freije"

Aging and chronic DNA damage response activate a regulatory pathway involving miR-29 and p53

Autor: Guillermo Mariño, Alejandro P. Ugalde, Jorge de la Rosa, Jun Lu, Andrew J. Ramsay, Carlos López-Otín, Ignacio Varela, Juan Cadiñanos, José M. Freije

Publikováno v: The EMBO Journal. 30:2219-2232

Aging is a multifactorial process that affects most of the biological functions of the organism and increases susceptibility to disease and death. Recent studies with animal models of accelerated aging have unveiled some mechanisms that also operate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::683752687e67af1c8da3c53c81143998
https://doi.org/10.1038/emboj.2011.124

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Nuclear DICKKOPF-1 as a biomarker of chemoresistance and poor clinical outcome in colorectal cancer

Publikováno v: Scopus-Elsevier
Scopus
RUO. Repositorio Institucional de la Universidad de Oviedo
instname
ResearcherID
Oncotarget. 2015 Mar 20;6(8):5903-17
UCrea Repositorio Abierto de la Universidad de Cantabria
Universidad de Cantabria (UC)
Biblos-e Archivo. Repositorio Institucional de la UAM
Europe PubMed Central
Digital.CSIC. Repositorio Institucional del CSIC
Oncotarget

This work is licensed under a Creative Commons Attribution 3.0 License.-- et al.
Sporadic colorectal cancer (CRC) insurgence and progression depend on the activation of Wnt/β-catenin signaling. Dickkopf (DKK)-1 is an extracellular inhibitor of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db79044eb5001dd41fd3eb31a558880f
http://hdl.handle.net/10261/123010

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Loss of ZMPSTE24 (FACE-1) causes autosomal recessive restrictive dermopathy and accumulation of Lamin A precursors

Autor: Raoul C.M. Hennekam, Claire Navarro, Rafaëlle Bernard, Fabienne Giuliano, Catherine Badens, Sébastien Courrier, Amandine Boyer, Pierre Cau, Frits A. Beemer, Juan Cadiñanos, Nicolas Lévy, Annachiara De Sandre-Giovannoli, Carlos López-Otín, José M. Freije, Irène Boccaccio, Anja Wagner, Wim J. Kleijer

Publikováno v: Human Molecular Genetics
Human Molecular Genetics, 2005, 14 (11), pp.1503-1513. ⟨10.1093/hmg/ddi159⟩
Human Molecular Genetics, 14(11), 1503-1513. Oxford University Press
Human molecular genetics, 14(11), 1503-1513. Oxford University Press
Human Molecular Genetics, Oxford University Press (OUP), 2005, 14 (11), pp.1503-1513. ⟨10.1093/hmg/ddi159⟩

International audience; Restrictive dermopathy (RD) is characterized by intrauterine growth retardation, tight and rigid skin with prominent superficial vessels, bone mineralization defects, dysplastic clavicles, arthrogryposis and early neo-natal de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a4fad7bbb20576221f200f98049758
https://doi.org/10.1093/hmg/ddi159

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Luminescence-based in vivo monitoring of NF-κB activity through a gene delivery approach

Autor: Jorge de la Rosa, José M. Freije, Fernando G. Osorio

Publikováno v: Cell Communication and Signaling : CCS

Background: Monitoring activity of specific signaling pathways in vivo is challenging and requires highly sensitive methods to detect dynamic perturbations in whole organisms. Results: In vivo gene delivery of a luciferase reporter followed by biolum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a9f32c3ba71206fbb303dd405169870
https://doi.org/10.1186/1478-811x-11-19

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Germ-line mutations in epidermal growth factor receptor (EGFR) are rare but may contribute to oncogenesis: A novel germ-line mutation in EGFR detected in a patient with lung adenocarcinoma

Autor: Aurora Astudillo, Patricia González-Arriaga, Primitiva Menéndez, Fernando Iglesias, José M. Freije, Adonina Tardón, Ana S. Pitiot, Milagros Balbín, Fernando G. Osorio, Íñigo Santamaría, Pilar Blay, Irene Centeno

Publikováno v: RUO. Repositorio Institucional de la Universidad de Oviedo
instname
BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 172 (2011)

Background A subset of lung cancer patients harbour EGFR somatic mutations in their tumours and are candidates for treatment with EGFR tyrosine kinase inhibitors. In a few cases EGFR mutations have also been found in the germ line, suggesting a role

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86426ddc93830765ded608e96c1d89df
http://hdl.handle.net/10651/6393

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Apolipoprotein D is the major protein component in cyst fluid from women with human breast gross cystic disease

Autor: José M. Freije, Carlos López-Otín, Antonio Fueyo, Luis M. Sánchez, Milagros Balbín

Publikováno v: Scopus-Elsevier

GCDFP(gross-cystic-disease-fluid protein)-24, a progesterone-binding protein present in large amounts in cyst fluid from human breast gross cystic disease, was purified in a one-step procedure by size-exclusion h.p.l.c. Peptide fragments obtained by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315da7ae6b7f3cc45f42a5cad4565d45
http://www.scopus.com/inward/record.url?eid=2-s2.0-0025184894&partnerID=MN8TOARS

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Mutational analysis of BRCA1 and BRCA2 in hereditary breast and ovarian cancer families from Asturias (Northern Spain)

Autor: Pilar Blay, Íñigo Santamaría, Ana S. Pitiot, M. Luque, Yolanda Fernández, José M. Freije, Milagros Balbín, Ana Lastra, Marta G. Alvarado, Ángeles Paredes

Publikováno v: BMC Cancer

Background The prevalence of BRCA1 and BRCA2 mutations in Spain is heterogeneous and varies according to geographical origin of studied families. The contribution of these mutations to hereditary breast and ovarian cancer has not been previously inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0b4a0807add98b09e808f85868f433

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