Zobrazeno 1 - 9
of 9
pro vyhledávání: '"José M. Espejo-Román"'
Galantamine Based Novel Acetylcholinesterase Enzyme Inhibitors: A Molecular Modeling Design Approach
Autor:
Luciane B. Silva, Elenilze F. B. Ferreira, Maryam, José M. Espejo-Román, Glauber V. Costa, Josiane V. Cruz, Njogu M. Kimani, Josivan S. Costa, José A. H. M. Bittencourt, Jorddy N. Cruz, Joaquín M. Campos, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 28, Iss 3, p 1035 (2023)
Acetylcholinesterase (AChE) enzymes play an essential role in the development of Alzheimer’s disease (AD). Its excessive activity causes several neuronal problems, particularly psychopathies and neuronal cell death. A bioactive pose on the hAChE B
Externí odkaz:
https://doaj.org/article/dc71a5ccb35141a8b7192fc4f562a8a2
Autor:
Lúcio R. Lima, Ruan S. Bastos, Elenilze F. B. Ferreira, Rozires P. Leão, Pedro H. F. Araújo, Samuel S. da R. Pita, Humberto F. De Freitas, José M. Espejo-Román, Edla L. V. S. Dos Santos, Ryan da S. Ramos, Williams J. C. Macêdo, Cleydson B. R. Santos
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 17, p 9927 (2022)
Aedes aegypti mosquitoes transmit several human pathogens that cause millions of deaths worldwide, mainly in Latin America. The indiscriminate use of insecticides has resulted in the development of species resistance to some such compounds. Piperidin
Externí odkaz:
https://doaj.org/article/871bed44ecde42f48e54e9dad5470e75
Identification of Potential Insect Growth Inhibitor against Aedes aegypti: A Bioinformatics Approach
Autor:
Glauber V. Da Costa, Moysés F. A. Neto, Alicia K. P. Da Silva, Ester M. F. De Sá, Luanne C. F. Cancela, Jeanina S. Vega, Cássio M. Lobato, Juliana P. Zuliani, José M. Espejo-Román, Joaquín M. Campos, Franco H. A. Leite, Cleydson B. R. Santos
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8218 (2022)
Aedes aegypti is the main vector that transmits viral diseases such as dengue, hemorrhagic dengue, urban yellow fever, zika, and chikungunya. Worldwide, many cases of dengue have been reported in recent years, showing significant growth. The best way
Externí odkaz:
https://doaj.org/article/49d98b59ec2c44a9aef729fa389aa1f3
Autor:
José M. Espejo-Román, Belén Rubio-Ruiz, Victoria Cano-Cortés, Olga Cruz-López, Saúl Gonzalez-Resines, Carmen Domene, Ana Conejo-García, Rosario M. Sánchez-Martín
Publikováno v:
Pharmaceutics, Vol 14, Iss 4, p 788 (2022)
Hyaluronic acid (HA), through its interactions with the cluster of differentiation 44 (CD44), acts as a potent modulator of the tumor microenvironment, creating a wide range of extracellular stimuli for tumor growth, angiogenesis, invasion, and metas
Externí odkaz:
https://doaj.org/article/2238b8db346d4857b7987836bf6f8676
Autor:
Pedro H. F. Araújo, Ryan S. Ramos, Jorddy N. da Cruz, Sebastião G. Silva, Elenilze F. B. Ferreira, Lúcio R. de Lima, Williams J. C. Macêdo, José M. Espejo-Román, Joaquín M. Campos, Cleydson B. R. Santos
Publikováno v:
Molecules, Vol 25, Iss 18, p 4183 (2020)
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of COX-1. Thus, the present study aims to identify new selective chemical entities for
Externí odkaz:
https://doaj.org/article/a33310ece1514aaab1316be5262273bc
Autor:
Maria Victoria Cano-Cortes, Francisco Javier López-Delgado, José M Espejo-Román, Juan D. Unciti-Broceta, Jose Antonio Laz-Ruiz, Juan J. Díaz-Mochón, Patricia Altea-Manzano, Rosario M. Sánchez-Martín
Publikováno v:
Digibug. Repositorio Institucional de la Universidad de Granada
Consejo Superior de Investigaciones Científicas (CSIC)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Consejo Superior de Investigaciones Científicas (CSIC)
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
In this manuscript, we report the development of a versatile, robust, and stable targeting nanocarrier for active delivery. This nanocarrier is based on bifunctionalized polymeric nanoparticles conjugated to a monoclonal antibody that allows for acti
Autor:
Williams Jorge da Cruz Macêdo, Cleydson B. R. Santos, José M Espejo-Román, José Ciríaco Pinheiro, R Silva, Carlos Henrique Tomich de Paula da Silva, Franco Henrique Andrade Leite, E.B. Costa, M.F. de A. Neto, Jorddy Neves Cruz
Publikováno v:
SAR and QSAR in Environmental Research. 31:677-695
A set of 23 steroidal 1,2,4,5-tetraoxane analogues were studied using quantum-chemical method (B3LYP/6-31 G*) and multivariate analyses (PCA, HCA, KNN and SIMCA) in order to calculate the properties and correlate them with antimalarial activity (log
Autor:
João Sammy Nery de Souza, Levy Bueno Alves, José M Espejo-Román, R Silva, Carlos Henrique Tomich de Paula da Silva, Njogu M. Kimani, Cleydson B. R. Santos, Silvana Giuliatti, Josiane V Cruz, Elenilze F B Ferreira
Publikováno v:
Journal of biomolecular structuredynamics. 40(12)
Cyclooxygenase 2 (COX-2) is a well-established target for the design of anti-inflammatory intermediates. Celecoxib was selected as a template molecule to perform ligand-based virtual screening, i.e. to search for structures with similarity in shape a
Autor:
Sebastião Gomes Silva, Joaquín M. Campos, Pedro H F Araújo, Cleydson B. R. Santos, José M Espejo-Román, Ryan da Silva Ramos, Williams Jorge da Cruz Macêdo, Lúcio R de Lima, Jorddy Neves Cruz, Elenilze F B Ferreira
Publikováno v:
Molecules, Vol 25, Iss 4183, p 4183 (2020)
Molecules
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Volume 25
Issue 18
Molecules
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Volume 25
Issue 18
Non-steroidal anti-inflammatory drugs are inhibitors of cyclooxygenase-2 (COX-2) that were developed in order to avoid the side effects of non-selective inhibitors of COX-1. Thus, the present study aims to identify new selective chemical entities for