Výsledky vyhledávání - "José M. Bartolomé"

mGlu5positive allosteric modulation normalizes synaptic plasticity defects and motor phenotypes in a mouse model of Rett syndrome

Autor: Jerri M. Rook, Rebecca K. Senter, Rocco G. Gogliotti, Shaun R. Stauffer, Carrie K. Jones, Ayan Ghoshal, Craig W. Lindsley, José M. Bartolomé, Thomas M. Bridges, P. Jeffrey Conn, Chrysa Malosh, Rocio Zamorano, J. Scott Daniels, Colleen M. Niswender

Publikováno v: Human Molecular Genetics. 25:1990-2004

Rett syndrome (RS) is a neurodevelopmental disorder that shares many symptomatic and pathological commonalities with idiopathic autism. Alterations in protein synthesis-dependent synaptic plasticity (PSDSP) are a hallmark of a number of syndromic for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b6e7f5a5d5eb2144a7c554c9f15fcf
https://doi.org/10.1093/hmg/ddw074

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Optimization of an ether series of mGlu5 positive allosteric modulators: Molecular determinants of MPEP-site interaction crossover

Publikováno v: Bioorganic & Medicinal Chemistry Letters. 22:6481-6485

We report the optimization of a series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on a simple acyclic ether series. Modifications led to a gain of MPEP site interaction through incorporati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d534ec9be8ddffac91a13e546689a725
https://doi.org/10.1016/j.bmcl.2012.08.043

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Synthesis of novel 3-substituted-2,3-dihydro-1,4-dioxino[2,3-b]pyridines as potential new scaffolds for drug discovery: selective introduction of substituents on the pyridine ring

Autor: José M. Bartolomé, Laura Iturrino, Jesús Alcázar, Encarnación Matesanz, Jose M. Alonso

Publikováno v: Tetrahedron Letters. 44:8983-8986

Selective introduction of substituents on 3-substituted-2,3-dihydro-1,4-dioxino[2,3- b ]pyridine at the pyridine ring was achieved using electrophilic aromatic substitution and addition–elimination reactions. In all the examples, functionalization

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02e96b66a60371f6d251be55df1e0ab3
https://doi.org/10.1016/j.tetlet.2003.10.005

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An easy and versatile synthesis of ureas from 2-benzylaminopyrimidine

Autor: José M. Bartolomé, Gregor James Macdonald, Michiel Van Gool

Publikováno v: Tetrahedron Letters. 49:7171-7173

A general procedure for the easy and versatile synthesis of ureas from 2-benzylaminopyrimidine is described. This methodology involves the preparation of a highly reactive carbamoyl chloride intermediate that can be further reacted with a high variet

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1054d2427aa369b73965949e63f97ffa
https://doi.org/10.1016/j.tetlet.2008.09.171

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Novel Approach towards the Synthesis of 3,3a,4,5-Tetrahydroquinolino[4,3-c]isoxazole Derivatives: Application to the Preparation of Previously Unattainable 3a,4-Dihydroazabenzopyrano[4,3-c]isoxazole Scaffolds

Autor: José M. Bartolomé, Javier Fernández, Jesús Alcázar, José Ignacio Andrés, Jose M. Alonso

Publikováno v: Synlett. :3139-3141

A novel synthetic approach towards the preparation of 3-substituted-7,8-dimethoxy-3,3a,4,5-tetrahydroquinolino[4,3-c]isoxazole derivatives is reported. Further application of this methodology to the preparation of previously unattainable 3a,4-dihydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89978cfb7cd30046de31d1db9e62b433
https://doi.org/10.1055/s-2005-921909

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