Zobrazeno 1 - 10 of 51 pro vyhledávání: '"José M Pérez-Victoria"'
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Akademický článek
LABCG2, a new ABC transporter implicated in phosphatidylserine exposure, is involved in the infectivity and pathogenicity of Leishmania.
Autor: Jenny Campos-Salinas, David León-Guerrero, Elena González-Rey, Mario Delgado, Santiago Castanys, José M Pérez-Victoria, Francisco Gamarro
Publikováno v: PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2179 (2013)
Leishmaniasis is a neglected disease produced by the intracellular protozoan parasite Leishmania. In the present study, we show that LABCG2, a new ATP-binding cassette half-transporter (ABCG subfamily) from Leishmania, is involved in parasite virulen
Externí odkaz: https://doaj.org/article/77ab182c883e4aa4804f34241e906b16
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3
Heme synthesis through the life cycle of the heme auxotrophic parasite Leishmania major
Autor: María Cabello-Donayre, Lina M. Orrego, Paola Vargas, Ricardo Molina, Marta Martínez-García, Maribel Jiménez, José M. Pérez-Victoria, Clara Sánchez, Estela Pineda-Molina
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Heme is an essential molecule synthetized through a broadly conserved 8-step route that has been lost in trypanosomatid parasites. Interestingly, Leishmania reacquired by horizontal gene transfer from γ-proteobacteria the genes coding for the last 3
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cc5dab0d8db8290ab03e95bcfb5661
https://doi.org/10.1096/fj.201901274rr
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4
Iron and Heme Metabolism at the Leishmania–Host Interface
Autor: Iqbal Hamza, Maria Fernanda Laranjeira-Silva, José M. Pérez-Victoria
Publikováno v: Trends Parasitol
Species of the protozoan Leishmania are causative agents of human leishmaniasis, a disease that results in significant death, disability, and disfigurement around the world. The parasite is transmitted to a mammalian host by a sand fly vector where i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ecd4904d68a1824c0b2a2eba3a8166
http://hdl.handle.net/10261/216571
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5
Heme synthesis through the life cycle of the heme auxotrophic parasite
Autor: Lina M, Orrego, María, Cabello-Donayre, Paola, Vargas, Marta, Martínez-García, Clara, Sánchez, Estela, Pineda-Molina, Maribel, Jiménez, Ricardo, Molina, José M, Pérez-Victoria
Publikováno v: FASEB journal : official publication of the Federation of American Societies for Experimental BiologyREFERENCES. 33(12)
Heme is an essential molecule synthetized through a broadly conserved 8-step route that has been lost in trypanosomatid parasites. Interestingly
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9473898ccf410cc16acf820879e56d1f
https://pubmed.ncbi.nlm.nih.gov/31553893
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6
Leishmania heme uptake involves LmFLVCRb, a novel porphyrin transporter essential for the parasite
Autor: Elisa Herraez, Belén Vicente, Jenny Campos-Salinas, Paola Vargas, Jose J.G. Marin, Ignacio Pérez-Victoria, María Cabello-Donayre, Marta Martínez-García, Lina M. Orrego, José M. Pérez-Victoria
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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Leishmaniasis comprises a group of neglected diseases caused by the protozoan parasite Leishmania spp. As is the case for other trypanosomatid parasites, Leishmania is auxotrophic for heme and must scavenge this essential compound from its human host
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66924f4b5e5ba00763e147d80311d486
http://hdl.handle.net/10261/213608
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7
Carbohydrate-naphthalene diimide conjugates as potential antiparasitic drugs: synthesis, evaluation and structure-activity studies
Autor: Mauro Freccero, Jean-Louis Mergny, Michela Zuffo, Adriana Adriana Stucchi, Filippo Doria, José M. Pérez-Victoria, Marta Martínez-García, Efres Belmonte-Reche, Juan Carlos Morales, María Cabello-Donayre, Jenny Campos-Salinas
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
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The neglected tropical diseases Human African Trypanosomiasis and leishmaniasis are caused by infection with trypanosomatid parasites Trypanosoma brucei and Leishmania spp, respectively. The genomes of these organisms contain multiple putative G-quad
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb58940caf6a09651784098dce0dd30d
http://hdl.handle.net/10261/194681
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Trypanosomatid parasites rescue heme from endocytosed hemoglobin through lysosomal HRG transporters
Autor: Francisco Javier Gálvez, Estela Pineda-Molina, Lina M. Orrego, Alba Rodríguez-Martínez, Marta Martínez-García, María P. Sánchez-Cañete, Antonio M. Estévez, José M. Pérez-Victoria, María Cabello-Donayre, Jenny Campos-Salinas, Sophie Malagarie-Cazenave
Publikováno v: Molecular Microbiology. 101:895-908
Pathogenic trypanosomatid parasites are auxotrophic for heme and they must scavenge it from their human host. Trypanosoma brucei (responsible for sleeping sickness) and Leishmania (leishmaniasis) can fulfill heme requirement by receptor-mediated endo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a84489b5271c5829be68549601995ed9
https://doi.org/10.1111/mmi.13430
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9
Semisynthesis of omega-Hydroxyalkylcarbonate Derivatives of Hydroxytyrosol as Antitrypanosome Agents
Autor: Francisco Rivas, Ignacio Fernandez-Pastor, Antonio Martínez, José M. Pérez-Victoria, Andrés Parra, Marta Martínez-García, Marta Medina-O'Donnell
Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Several lipophilic omega-hydroxyalkylcarbonate hydroxytyrosol derivatives and also their corresponding dimeric derivatives have been synthesized, coupling the primary hydroxy group of this phenolic compound with several terminal diols of different ch
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3193460a101d3552aa431595b02d2b72
http://hdl.handle.net/10261/194893
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10
G-Quadruplex Identification in the Genome of Protozoan Parasites Points to Naphthalene Diimide Ligands as New Antiparasitic Agents
Autor: Jose Juan Lopez-Rubio, Michela Zuffo, Juan Carlos Morales, Jean-Louis Mergny, Jenny Campos-Salinas, José M. Pérez-Victoria, Matilde Arévalo-Ruiz, Filippo Doria, Efres Belmonte-Reche, Marta Martínez-García, Mauro Freccero, Aurore Guédin, Marjorie Maynadier
Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2018, 61 (3), pp.1231-1240. ⟨10.1021/acs.jmedchem.7b01672⟩
Digital.CSIC. Repositorio Institucional del CSIC
instname
G-quadruplexes (G4) are DNA secondary structures that take part in the regulation of gene expression. Putative G4 forming sequences (PQS) have been reported in mammals, yeast, bacteria, and viruses. Here, we present PQS searches on the genomes of T.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b37134663c264709b225f4f349119ae
http://hdl.handle.net/10261/163518
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