Zobrazeno 1 - 10
of 10
pro vyhledávání: '"José M Lopez-Novoa"'
Autor:
Bárbara Oujo, José M Muñoz-Félix, Miguel Arévalo, Elena Núñez-Gómez, Lucía Pérez-Roque, Miguel Pericacho, María González-Núñez, Carmen Langa, Carlos Martínez-Salgado, Fernando Perez-Barriocanal, Carmelo Bernabeu, José M Lopez-Novoa
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e110365 (2014)
Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains un
Externí odkaz:
https://doaj.org/article/afc1c5af650941a680ac8824e3fe9421
Publikováno v:
Frontiers in Genetics, Vol 5 (2015)
Mutations in the endoglin gene (ENG) are responsible for approximately 50% of all cases with Hereditary Hemorrhagic Telangectasia (HHT). Because of the absence of effective treatments for HHT symptoms, studies aimed at identifying novel biological fu
Externí odkaz:
https://doaj.org/article/1df75ff0d4484227a2733cf7259f1347
Autor:
Ivana Nemeckova, Agnieszka Serwadczak, Barbara Oujo, Katerina Jezkova, Jana Rathouska, Petra Fikrova, Michala Varejckova, Carmelo Bernabeu, Jose M Lopez-Novoa, Stefan Chlopicki, Petr Nachtigal
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119665 (2015)
Increased levels of a soluble form of endoglin (sEng) circulating in plasma have been detected in various pathological conditions related to cardiovascular system. High concentration of sEng was also proposed to contribute to the development of endot
Externí odkaz:
https://doaj.org/article/87c695d80bfc4061b3ae8f0a0b788af6
Autor:
Ana M Blázquez-Medela, Omar García-Sánchez, Víctor Blanco-Gozalo, Yaremi Quiros, María J Montero, Carlos Martínez-Salgado, José M López-Novoa, Francisco J López-Hernández
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105988 (2014)
BackgroundHypertension and diabetes are the two leading causes of chronic kidney disease (CKD) eventually leading to end stage renal disease (ESRD) and the need of renal replacement therapy. Mortality among CKD and ESRD patients is high, mostly due t
Externí odkaz:
https://doaj.org/article/73a0e3e27fe94d44a6e650ef33050f6a
Autor:
Miguel Pericacho, Soraya Velasco, Marta Prieto, Elena Llano, José M López-Novoa, Alicia Rodríguez-Barbero
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54687 (2013)
Accurate regulation of dermal fibroblast function plays a crucial role in wound healing. Many fibrotic diseases are characterized by a failure to conclude normal tissue repair and the persistence of fibroblasts inside lesions. In the present study we
Externí odkaz:
https://doaj.org/article/87a20eb81c8b44f1870d910b2b0c4d20
Autor:
Daniel Beiroa, Amparo Romero-Picó, Carmen Langa, Carmelo Bernabeu, Miguel López, José M López-Novoa, Ruben Nogueiras, Carlos Diéguez
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54591 (2013)
Endoglin is a transmembrane auxiliary receptor for transforming growth factor-beta (TGF-beta) that is predominantly expressed on proliferating endothelial cells. It plays a wide range of physiological roles but its importance on energy balance or ins
Externí odkaz:
https://doaj.org/article/18d2ad14aec3418aaa67101302935b79
Autor:
Melania Kurdián, Inmaculada Herrero-Fresneda, Nuria Lloberas, Pepita Gimenez-Bonafe, Virginia Coria, María T Grande, José Boggia, Leonel Malacrida, Joan Torras, Miguel A Arévalo, Francisco González-Martínez, José M López-Novoa, Josep Grinyó, Oscar Noboa
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32516 (2012)
BackgroundThe immunosuppressive mammalian target of rapamycin (mTOR) inhibitors are widely used in solid organ transplantation, but their effect on kidney disease progression is controversial. mTOR has emerged as one of the main pathways regulating c
Externí odkaz:
https://doaj.org/article/af232cd236874a11ba395d91515663ac
Autor:
Isabel Fuentes-Calvo, Ana M Blázquez-Medela, Eugenio Santos, José M López-Novoa, Carlos Martínez-Salgado
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8703 (2010)
BACKGROUND: Ras GTPases are considered cytoplasmic proteins that must be localized to cell membranes for activation, and there are few evidences of the presence of any Ras isoform in nuclei of eukaryotic cells. METHODOLOGY/PRINCIPAL FINDINGS: Using c
Externí odkaz:
https://doaj.org/article/d1b278d473a64b5595ec4386c00df54f
Autor:
Cristina Egido-Turrión, Elisa Rossi, Claudia Ollauri-Ibáñez, María L. Pérez-García, María A. Sevilla, José María Bastida, José Ramón González-Porras, Alicia Rodríguez-Barbero, Carmelo Bernabeu, José M. Lopez-Novoa, Miguel Pericacho
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal-dominant genetic disorder involving defects in two predominant genes known as endoglin (ENG; HHT-1) and activin receptor-like kinase 1 (ACVRL1/ALK1; HHT-2). It is characterized by mucocutane
Externí odkaz:
https://doaj.org/article/d9857183e7e549468b77a46d55d5f672
Autor:
Garcia-Cenador MB; 1 Department of Surgery, University of Salamanca, Salamanca, Spain. 2 Biosanitary Research Institute (IBSAL), Salamanca Spain. 3 Digna Biotech, Madrid, Spain. 4 Department of Nephrology, Hospital del Mar, IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain. 5 Renal and Cardiovascular Physiopathology Unit, Department of Physiology and Pharmacology, University of Salamanca, Salamanca, Spain. 6 Queen Sofía Institute for Renal Research, Renal Foundation, Madrid, Spain. 7 Address correspondence to: José M. Lopez-Novoa Ph.D., Renal and Cardiovascular Physiopathology Unit, Department of Physiology and Pharmacology, University of Salamanca, Edificio Departamental, Campus Unamuno, 37007 Salamanca, Spain., Lorenzo-Gomez MF, Herrero-Payo JJ, Ruiz J, Perez de Obanos MP, Pascual J, Lopez-Novoa JM, Garcia-Criado FJ
Publikováno v:
Transplantation [Transplantation] 2013 Dec 27; Vol. 96 (12), pp. 1034-42.