Zobrazeno 1 - 9
of 9
pro vyhledávání: '"José M Frade"'
Autor:
María C Ovejero-Benito, José M Frade
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64890 (2013)
Neurodegeneration is often associated with DNA synthesis in neurons, the latter usually remaining for a long time as tetraploid cells before dying by apoptosis. The molecular mechanism preventing G2/M transition in these neurons remains unknown, but
Externí odkaz:
https://doaj.org/article/b3ca5c28adcb4ba085dc5e03f85b8c9c
Autor:
Ana M Santos, Noelia López-Sánchez, David Martín-Oliva, Pedro de la Villa, Miguel A Cuadros, José M Frade
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36243 (2012)
Both proNGF and the neurotrophin receptor p75 (p75(NTR)) are known to regulate photoreceptor cell death caused by exposure of albino mice to intense illumination. ProNGF-induced apoptosis requires the participation of sortilin as a necessary p75(NTR)
Externí odkaz:
https://doaj.org/article/7f6f855afc0a4059a07c1585a4e6f9f8
Autor:
Anna Lozano-Ureña, José M. Frade
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Alterations in adult neurogenesis are a common hallmark of neurodegenerative diseases. Therefore, understanding the molecular mechanisms that control this process is an indispensable requirement for designing therapeutic interventions addressing neur
Externí odkaz:
https://doaj.org/article/e1f01b21eb724f98b710b5229f3a1447
Autor:
Morgan Ramón-Landreau, Cristina Sánchez-Puelles, Noelia López-Sánchez, Anna Lozano-Ureña, Aina M. Llabrés-Mas, José M. Frade
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 20, p 12093 (2022)
E2F4 was initially described as a transcription factor with a key function in the regulation of cell quiescence. Nevertheless, a number of recent studies have established that E2F4 can also play a relevant role in cell and tissue homeostasis, as well
Externí odkaz:
https://doaj.org/article/e53611512e254bcca33ba4a6a1dbecef
Autor:
José M. Frade
Publikováno v:
Physics Essays. 35:258-265
The general theory of relativity (GTR) has proved to accurately describe all gravitational aspects of our universe. This theory was developed by Einstein under the premises of the principle of equivalence to describe the behavior of inertial systems
Autor:
José M. Frade
Publikováno v:
Physics Essays. 33:34-37
Spacetime is deterministic, but the Universe appears to be stochastic. How to reconcile free will with the determinism inherent to the Universe? In this essay, we postulate that free will can only emanate from the existence of multiple additional spa
Autor:
Noelia, López-Sánchez, José M, Frade
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1254
The use of flow cytometry in vertebrate nervous tissues is hampered by the morphological complexity and high level of interconnectivity intrinsic to their cellular constituents. Here we describe a simplified procedure for the identification and quant
Publikováno v:
Results and problems in cell differentiation. 53
Somatic tetraploid neurons are present in different structures of the vertebrate nervous system, including cortex and retina. In this chapter, we provide evidence that these neurons can be widely detected in the chick nervous system. We also discuss
Publikováno v:
Frontiers in Genetics, Vol 11 (2020)
When subjected to stress, terminally differentiated neurons are susceptible to reactivate the cell cycle and become hyperploid. This process is well documented in Alzheimer’s disease (AD), where it may participate in the etiology of the disease. Ho
Externí odkaz:
https://doaj.org/article/f2c0232f4c8c4453a7871c2436526a04